In a conventional MPI engine, a pulsation damper is usually mounted on the fuel rail to diminish undesirable noise in the vehicle cabin room; however, pulsation dampers are quite expensive. Therefore, several studies have focused on reducing fuel pressure pulsation by increasing the self-damping characteristics of the fuel rail. This paper details the development of a fuel rail that reduces pulsation using a self-damping effect. Using an oil hammer simulation technique, pressure pulsation characteristics were investigated with respect to the aspect ratio of the cross-section, wall thickness, and fuel rail material. Increasing the aspect ratio and decreasing the wall thickness efficiently reduced the pressure pulsation. In addition, the pressure pulsation characteristics were investigated with respect to the resonant engine speed and injection period. These simulated data can be used to reduce the pressure pulsation peak and to avoid the resonant point in the design stage during the development of a fuel rail.