Purpose: The purpose of this study was to develop a nocturnal emission and menstruation education program using CAI for Korean elementary school children. Methods: The research design was methodological study a ISD model 4 fields into sub contents in each field of the nocturnal emission and menstruation by CD titles. And to verify the effect of the education program, performance evaluation of the educational program for structured questionnaire was conducted on 120 late school-age children on June, 2010. Results: The results of this study were as follows; Through this, developed program was proved its effectiveness in enhancing knowledge level on nocturnal emission and menstruation in late school-age children(t=14.03, p<.001, t=11.52, p<.001). Conclusion : Accordingly, this program is expected to be an educational program to be used in various educational institutes, communities, and home as well as self-study that allows children themselves to study repeatedly, choosing the contents they want, whenever they hope as an educational program on nocturnal emission and menstruation in school-age children. In addition, it is suggested that various fields of programs should develop in consideration of early sexual maturity.