Inlet part of a printed circuit heat exchanger has been optimized by using three-dimensional Reynolds-Averaged Navier-Stokes analysis and surrogate modeling techniques. Kriging model has been used as the surrogate model. The objective function for the optimization has been defined as a linear combination of uniformity of mass flow rate and the pressure loss with a weighting factor. For the optimization, the angle of the inlet plenum wall, radius of curvature of the inlet plenum wall, and width of the inlet pipes have been selected as design variables. Twenty six design points are obtained by Latin Hypercube Sampling in design space. Through the optimization, considerable improvement in the objective function has been obtained in comparison with the reference design of PCHE.