Soft storey failure mechanism is a common collapse mode for masonry-infilled (MI) reinforced concrete (RC) buildings subjected to severe earthquakes. Simple analytical equations correlating global with local ductility demands are derived from pushover (PO) analyses for seismic assessments of regular MI RC frames, considering the critical interstorey drift ratio, number of storeys and lateral loading configurations. The reliability of the equations is investigated using incremental dynamic analyses for MI RC frames of up to 7 storeys. Using the analytical ductility relationship and a coefficient-based method (CBM), the response spectral accelerations and period shift factors of low-rise MI RC frames are computed. The results are verified through published shake table test results. In general applications, the analytical ductility relationships thus derived can be used to bypass the onerous PO analysis while accurately predicting the local ductility demands for seismic assessment of regular MI RC frames.