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뇌졸중 쥐모델에서 비침습적뇌자극치료 이후 신경생리학적 검사에서 나타난 뇌가소성과 연관된 변화
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  • 뇌졸중 쥐모델에서 비침습적뇌자극치료 이후 신경생리학적 검사에서 나타난 뇌가소성과 연관된 변화
  • Plasticity Associated Changes in Neurophysiological Tests Following Non Invasive Brain Stimulation in Stroke Rat Model
저자명
손민균,송희정,지성주,Sohn. Min Kyun,Song. Hee-Jung,Jee. Sungju
간행물명
대한임상신경생리학회지
권/호정보
2014년|16권 2호|pp.62-69 (8 pages)
발행정보
대한임상신경생리학회
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이 논문은 한국과학기술정보연구원과 논문 연계를 통해 무료로 제공되는 원문입니다.
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기타언어초록

Background: Neuromodulation therapy has been used to an adjunctive treatment promoting motor recovery in stroke patients. The objective of the study was to determine the effect of repetitive transcranial magnetic stimulation (rTMS) on neurobehavioral recovery and evoked potentials in rats with middle cerebral artery occlusion. Methods: Seventy Sprague-Daley rats were induced permanent middle cerebral artery occlusion (MCAO) stroke model and successful stroke rats (n=56) assigned to the rTMS (n=28) and sham (n=28) group. The 10 Hz, high frequency rTMS gave on ipsilesional forepaw motor cortex during 2 weeks in rTMS group. The somatosensory evoked potential (SSEP) and motor evoked potential (MEP) were used to evaluate the electrophysiological changes. Behavioral function of the stroke rat was evaluated by the Rota rod and Garcia test. Results: Forty rats ($N_{rTMS}=20;;N_{sham}=20$) completed all experimental course. The rTMS group showed better performance than sham group in Rota rod test and Garcia test at day 11 (p<0.05) but not day 18 (p>0.05). The amplitude of MEP and SSEP in rTMS group was larger than sham group at day 18 (p<0.05). Conclusions: These data confirm that the high frequency rTMS on ipsilesional cerebral motor cortex can help the early recovery of motor performance in permanent middle cerebral artery stroke model and it may simultaneously associate with changes in neurophysiological activity in brain.