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밤 과육, 껍질 및 밤나무 잎 추출물에 대한 항산화 및 항염증 활성 비교
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  • 밤 과육, 껍질 및 밤나무 잎 추출물에 대한 항산화 및 항염증 활성 비교
저자명
김진윤,김승연,권형민,김찬현,이승진,박승춘,김경화,Kim. Jin Yoon,Kim. Seung Yeon,Kwon. Hyoung Min,Kim. Chan Hyun,Lee. Seung Jin,Park. Seung Chun,Kim. K
간행물명
韓國藥用作物學會誌
권/호정보
2014년|22권 1호|pp.8-16 (9 pages)
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한국약용작물학회
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이 논문은 한국과학기술정보연구원과 논문 연계를 통해 무료로 제공되는 원문입니다.
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기타언어초록

The present study was carried out to evaluate the antioxidant and anti-inflammatory activities of three extracts (hot water, 50% ethanol and mixed solvent;water, ethanol, butylene glycol, propylene glycol) of dried chestnut, chestnut shell, chestnut leaves and dried chestnut leaves obtained from Castanea crenata tree. When conducted DPPH assay, radical scavenging activity of ethanol extract of chestnut shell was the highest with $IC_{50}$ $10.8{mu}g/mL$ among four extracts from these parts (p < 0.05). In additional results by the xanthine oxidase assay, antioxidant activity showed that water extract of chestnut leaves showed the highest xanthine oxidase inhibitory activity in the tested extracts (p < 0.05). Futhermore, extracts of chestnut shell and leaves exhibited no cytotoxicity in RAW 264.7 cells (p < 0.05). Also, anti-inflammatory activity by NO assay showed LPS-induced NO was significantly inhibited following treatment with extracts of chestnut shell and leaves of 3mg/mL (p < 0.05). These data suggest that extract of chestnut shell have antioxidant and anti-inflamantory activity including chestnut leaves. Therefore, it is considered that Castanea crenata research range and selection of functional material can broaden chestnut shell to other fractions such as chestnut and chestnut leaves.