Mufflers have been widely used in the exhaust system to reduce the noise. However, installing muffler may deteriorate the efficiency due to the increase of back pressure. Mufflers usually consist of partition plates and perforated holes in a expansion chamber. In this paper, the influences of the location of the partition and hole on the acoustic TL and back pressure were examined. The acoustic TL was predicted using virtual lab commercial software, while the back pressure were predicted using CFX commercial software. The results were used to set up a database for finding their trends. The optimal muffler model in user-interested frequency range could be selected by analyzing this database.