구강내 골 결손을 회복하기 위해 골이식술의 재료로 자가골은 gold standard1) 로 알려져 왔지만 골 결손부 의 크기나 형태, 적절한 공여부 조직의 부족, 이차적 인 수술적 접근으로 인한 부담 등은 자가골 이용의 제 한 요인이기도 하다2). 또한 자가골은 이식부에 거부 반응 없이 생착되는 반면 그 흡수량이 예측 불가능하 고 이식골의 종류, 고정의 방식, 골화 기원에 따라 많 은 영향을 받는다.
Purpose : Bio-glass proved to be grafting substitute material, providing a reasonable bio-degradation time, and no need for harvesting procedure. The purpose of this study is to evaluate application of Bio-glass as a bone graft material for grafting procedure. Material & Method : Sixteen rabbits were divided into 4 groups of 4 periods. The autogenous bone and Bio-glass were grafted in rabbit cranial defects. The rabbits were sacrificed at 2, 4, 8, and 12 weeks, and the histologic and immunohistochemical analyses were used to investigate bone regeneration phase. Result : 1. The new bone formation around autogenous bone and Bio-glass was seen from 2 weeks, but Bio-glass part was not seen incremented for each period. 2. In autogeneous bone graft,BMP 2/4/7 expression was most increased at 4 weeks. 3. In Bio-glass graft, BMP 2/4/7 expression was most increased at 12 weeks. Conclusion : We considered that bio-blass cannot be a suitable material for grafting and augmentation at defected area, and further study will be needed.
Ⅰ. 서론 II. 연구재료 및 방법 Ⅲ. 연구결과 Ⅳ. 총괄 및 고찰 Ⅴ. 결론 REFERENCES
