This study is to analyse the structural relationship of social participation, social support, empowerment and quality of life among Vietnamese marriage immigrant women in Jeonbuk province. The research aims to find the structural relationship of social participation, social support, empowerment and quality of life among Vietnamese marriage immigrant women. The results are as following: In the structural relationship of social participation, social support, empowerment and quality of life among Vietnamese marriage immigrant women in Jeonbuk province, Social support has a significant impact on the quality of life(β=.414 p=.017). Social support is also significant with empowerment(β=.844 p=.006), which is significant with quality of life(β=.462 p=.006). In the relation of social support and quality of life, direct effect and indirect effect were found to have significance on the path of empowerment to quality of life(direct effect size: .411, p=.017, indirect effect size: .390, p=.001, total effect size: .804, p=.001). However, social participation had effects on quality of life by intervention of cultural adaptation is no significant difference in quality of life. Based on the study, program has to be provided for Vietnamese marriage immigrant women participating in social integration and diverse social participation to receive social support. Vietnamese Marriage immigrant women have to form the identity and reinforce the capability by participating various cultural programs. Through this process, the local community can be transformed into a multicultural community through human interaction with local social members. In addition, providing an environment for Vietnamese marriage immigrant women such as continuous independent meeting, the quality of life for Vietnamese marriage immigrant women could be improved by activating social participation.