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본문검색 결과만 보기
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Hypoxia induces Wee1 expression and attenuates hydrogen peroxide-induced endothelial damage in MS1 cells
Hong. Ki-Sun, Kim. Hyeon-Soo, Kim. Se-Hoon, Lim. Dong-Jun, Park. Jung-Yul, Kim. Sang-Dae 생화학분자생물학회 Experimental & molecular medicine : EMM 7 Pages
생화학분자생물학회 Experimental & molecular medicine : EMM 2011, Vol.43 No.12 653-659 (7 pages)
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Time-course analysis of DNA damage response-related genes after $in$ $vitro$ radiation in H460 and H1229 lung cancer cell lines
Kim. Kang-Ho, Yoo. Hae-Yong, Joo. Kyeung-Min, Jung. Yong, Jin. Ju-Youn, Kim. Yong-Hyun, Yoon. Su-Jin, Choi. Seung-Ho, Seol. Ho-Jun, Park. 생화학분자생물학회 Experimental & molecular medicine : EMM 8 Pages
생화학분자생물학회 Experimental & molecular medicine : EMM 2011, Vol.43 No.7 419-426 (8 pages)
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Imipramine enhances neuroprotective effect of PEP-1-Catalase against ischemic neuronal damage
Kim. Dae-Won, Kim. Duk-Soo, Kim. Mi-Jin, Kwon. Soon-Won, Ahn. Eun-Hee, Jeong. Hoon-Jae, Sohn. Eun-Jeong, Dutta. Suman, Lim. Soon-Sung, Ch 생화학분자생물학회 BMB reports 6 Pages
생화학분자생물학회 BMB reports 2011, Vol.44 No.10 647-652 (6 pages)
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Analysis of protein expression in Brucella abortus mutants with different growth rates by two-dimensional gel electrophoresis and LC-MS/MS peptide analysis
Woo Bin Park, Young Bin Im, Soojin Shim, Han Sang Yoo 대한수의학회 Journal of Veterinary Science 16 Pages
대한수의학회 Journal of Veterinary Science 2018, 제 19권 제 2호 8 216-231 (16 pages)
mutant and wild-type B. abortus were purified and subjected to two-dimensional gel electrophoresis. Thirty protein spots of each mutant with expression increases or decreases were selected; those with a change of more than 2-fold were compared with the wild-type. Selected spots underwent liquid chromatography tandem mass spectrometry for peptide analysis. DnaK and ClpB, involved in protein aggregation, increased. SecA and GAPDH, associated with energy metabolism, decreased in some mutants with a... -
Tissue-specific expression of the NOD-like receptor protein 3 in BALB/c mice
Zhiqiang Huang, Meng Yu, Shuang Tong, Kun Jia, Rongchang Liu, Heng Wang, Shoujun Li*, Zhangyong Ning* 대한수의학회 Journal of Veterinary Science 5 Pages
대한수의학회 Journal of Veterinary Science 2014, 제 15권 제 2호 1 173-177 (5 pages)
as NOD-like receptors. The NOD-like receptor protein 3 (NLRP3) inflammasome is involved in induction of the pro- inflammatory cytokine, IL-1β, and subsequent inflammatory responses. NLRP3 inflammasome plays important roles in the inflammatory and innate immune responses associated with autoimmune/inflammatory syndrome. However, analysis of the tissue distribution and expression profiles in BALB/c mice is still incomplete. In this study, we investigated the tissue distribution and expression... -
Protein kinase C beta II upregulates intercellular adhesion molecule-1 via mitochondrial activation in cultured endothelial cells
HeeKyoungJoo, YuRanLee, SungaChoi, MyoungSooPark, GunKang, Cuk-SeongKim, ByeongHwaJeon 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2017, Vol.21 No.4 3 377-384 (8 pages)
protein kinase C (PKC) is closely linked with endothelial dysfunction. However, the effect of PKCβII on endothelial dysfunction has not been characterized in cultured endothelial cells. Here, using adenoviral PKCβII gene transfer and pharmacological inhibitors, the role of PKCβII on endothelial dysfucntion was investigated in cultured endothelial cells. Phorbol 12-myristate 13-acetate (PMA) increased reactive oxygen species (ROS), p66shc phosphorylation, intracellular adhesion molecule-1, and... -
2-(4-Hydroxyphenyl)-5-(3-Hydroxypropenyl)-7-Methoxybenzofuran, a Novel Ailanthoidol Derivative, Exerts Anti-Inflammatory Effect through Downregulation of Mitogen-Activated Protein Kinase in Lipopolysaccharide-Treated RAW 264.7 Cells
HyeonJinKim, Jong-GabJun, Jin-KyungKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2013, Vol.17 No.3 6 217-222 (6 pages)
of prostaglandin (PG) E2 and the expression of inducible NO synthase and cyclooxygenase (COX)-2 induced by LPS, and inhibited the release of LPS-induced pro-inflammatory cytokines from RAW264.7 cells. The underlying mechanism of compound 4 on anti-inflammatory action was correlated with the down-regulation of mitogen-activated protein kinase and activator protein-1 activation. Compound 4 is potentially an effective functional chemical candidate for the prevention of inflammatory diseases. -
Role of Protein Kinases on NF-κB Activation and Cell Death in Bovine Cerebral Endothelial Cells
YoungSooAhn, ChulHoonKim, JooHeeKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1999, Vol.3 No.1 2 11-18 (8 pages)
κB (NF-κB) activation is modulated by various protein kinases. Activation of NF-κB is known to be important in the regulation of cell viability. The present study investigated the effect of inhibitors of protein tyrosine kinase (PTK), protein kinase C (PKC) and protein kinase A (PKA) on NF-κB activity and the viability of bovine cerebral endothelial cells (BCECs). In serum-deprivation-induced BCEC death, low doses of TNFα showed a protective effect. TNFα induced NF-κB activation within 4... -
HMGB1 Switches Alkylating DNA Damage-Induced Apoptosis to Necrosis
이수연, 정의경, 전현민, 주민경, 김초희, 박혜경, 강호성, Lee. Su-Yeon, Jeong. Eui-Kyong, Jeon. Hyun-Min, Ju. Min-Kyung, Kim. Cho-Hee, Park. Hye-Gyeong, Kang. Ho-Su 한국생명과학회 생명과학회지 8 Pages
한국생명과학회 생명과학회지 2011, Vol.21 No.7 953-960 (8 pages)
세포괴사는 세포막의 파열, HMGB1을 포함한 세포 내용물의 세포외부로의 방출 등을 수반하는 세포죽음이다. HMGB1은 핵 단백질로 전사조절자로 작용하지만 세포괴사에 의해 세포 밖으로 방출되면 염증을 유발하고 암을 촉진하는 cytokine으로 작용한다. HMGB1의 과발현은 암 발생 및 항암제 저항과 밀접한 연관성을 가지고 있지만, 그 기작에 대한 연구는 미흡한 실정이다. 본 연구에서는, HMGB1이 항암제에 의한 세포 죽음에 미치는 영향을 조사하였다. 그 결과, HMGB1은 MCF-7, MDA-MB231, MDA-MB361 세포에서 cisplatin에 의한...
