주제분류
- 자연과학(94)
- 농수해양학(79)
- 의약학(55)
- 교육학(14)
- 인문학(6)
- 보건학(5)
- 사회과학(4)
- 심리학(4)
- 기타(2)
- 예체능(2)
- 유아교육학(2)
- 사회복지학(1)
- 특수교육학(1)
자료유형
발행기관
- 한국식물병리학회(85)
- 대한수의학회(79)
- 대한생리학회-대한약리학회(51)
- 한국습지학회(7)
- 한국교육학회(4)
- 한국기초간호학회(4)
- 한국박물관학회(3)
- 경인교육대학교 교육연구원(2)
- 대한신경정신의학회(2)
- 인문사회과학기술융합학회(2)
- 한국고고학회(2)
- 한국교육행정학회(2)
- 한국여가문화학회(2)
- 한국탄소학회(2)
- 환태평양유아교육연구학회(2)
- 대한약리학회(1)
- 부산대학교 교육발전연구소(1)
- 서강대학교 철학연구소(1)
- 아시아장애사회학회(1)
- 이화여자대학교 교과교육연구소(1)
- 인지발달중재학회(1)
- 한국교원교육학회(1)
- 한국교육방법학회(1)
- 한국독서교육학연구회(1)
- 한국모래상자치료학회(1)
- 한국무용동작심리치료학회(1)
- 한국보건기초의학회(1)
- 한국시각장애교육재활학회(1)
- 한국심리치료학회(1)
- 한국음악교육공학회(1)
- 한국음악교육학회(1)
- 한국인간발달학회(1)
- 한국조형교육학회(1)
- 한국환경복원기술학회(1)
- 한방비만학회(1)
간행물
- THE PLANT PATHOLOGY JOURNAL (75)
- JOURNAL OF VETERINARY SCIENCE(52)
- THE KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY(51)
- 대한수의학회 학술대회발표집(19)
- 식물병연구(10)
- KOREAN JOURNAL OF VETERINARY RESEARCH(구 대한수의학회지)(8)
- 한국습지학회지(7)
- JOURNAL OF KOREAN BIOLOGICAL NURSING SCIENCE(4)
- 한국교육학회 학술대회논문집(4)
- 박물관학보(3)
- ASIA-PACIFIC JOURNAL OF RESEARCH IN EARLY CHILDHOOD EDUCATION(2)
- CARBON LETTERS(2)
- 교육논총(2)
- 교육행정학연구(2)
- 신경정신의학(2)
- 여가학연구(2)
- 예술인문사회융합멀티미디어논문지(2)
- EASTWEST EDUCATION (1)
- 교육방법연구(1)
- 교육연구(1)
- 대한약리학잡지(1)
- 대한한방비만학회지(1)
- 독서교육연구(1)
- 모래상자치료연구(1)
- 무용동작치료논문집(1)
- 시각장애연구(1)
- 아시아장애사회학연구(1)
- 음악교육공학(1)
- 음악교육연구(1)
- 인간발달연구(1)
- 인지발달중재학회지(1)
- 조형교육(1)
- 철학논집(1)
- 한국고고학보(1)
- 한국고고학전국대회 발표문(1)
- 한국교원교육연구(1)
- 한국보건기초의학회지(1)
- 한국심리치료학회지(1)
- 환경복원녹화(1)
전체 선택해제
총 269건 검색
본문검색 결과만 보기
-
Tat-Mediated p66shc Transduction Decreased Phosphorylation of Endothelial Nitric Oxide Synthase in Endothelial Cells
SangKiLee, JiYoungLee, HeeKyoungJoo, EunJungCho, CukSeongKim, SangDoLee, JinBongPark, ByeongHwaJeon 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2012, Vol.16 No.3 8 199-204 (6 pages)
We evaluated the role of Tat-mediated p66shc transduction on the activation of endothelial nitric oxide synthase in cultured mouse endothelial cells. To construct the Tat-p66shc fusion protein, human full length p66shc cDNA was fused with the Tat-protein transduction domain. Transduction of TAT-p66shc showed a concentration- and time-dependent manner in endothelial cells. Tat-mediated p66shc transduction showed increased hydrogen peroxide and superoxide production, compared with Tat-p66shc... -
Defective Mitochondrial Function and Motility Due to Mitofusin 1 Overexpression in Insulin Secreting Cells
Kyu-SangPark, reasWiederkehr, ClaesB.Wollheim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2012, Vol.16 No.1 11 71-77 (7 pages)
of wild type (WT-Mfn1) or a dominant negative mitofusin 1 mutant (DN-Mfn1). Mitochondrial morphology and motility were analyzed by monitoring mitochondrially-targeted red fluorescent protein. Adenovirus- driven overexpression of WT-Mfn1 elicited severe aggregation of mitochondria, preventing them from reaching peripheral near plasma membrane areas of the cell. Overexpression of DN-Mfn1 resulted in fragmented mitochondria with widespread cytosolic distribution. WT-Mfn1 overexpression impaired... -
Spontaneous Oscillatory Rhythm in Retinal Activities of Two Retinal Degeneration (rd1 and rd10) Mice
YongSookGoo, KunNoAhn, YeongJunSong, SuHeokAhn, SeungKeeHan, SangBaekRyu, KyungHwanKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2011, Vol.15 No.6 13 415-422 (8 pages)
Previously, we reported that besides retinal ganglion cell (RGC) spike, there is ∼10 Hz oscillatory rhythmic activity in local field potential (LFP) in retinal degeneration model, rd1 mice. The more recently identified rd10 mice have a later onset and slower rate of photoreceptor degeneration than the rd1 mice, providing more therapeutic potential. In this study, before adapting rd10 mice as a new animal model for our electrical stimulation study, we investigated electrical characteristics of... -
Social Isolation Selectively Increases Anxiety in Mice without Affecting Depression-like Behavior
ChuljungKwak, Sue-HyunLee, Bong-KiunKaang 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 4 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2009, Vol.13 No.5 4 357-360 (4 pages)
emotional functions. For example, laboratory mice which had restricted environment showed different synaptic potentiation properties with wild mice (Zhao MG et al., 2009). While performing behavioral experiments, however, it is sometimes inevitable that the researcher changes the animals' environments, as by switching the cages in which experimental animals are housed and separating animals raised together into small experimental groups. In this study, we investigated the effect of environmental... -
Block of hERG K＋ Channel by Classic Histamine H1 Receptor Antagonist Chlorpheniramine
Hee-KyungHong, Su-HyunJo 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2009, Vol.13 No.3 12 215-220 (6 pages)
Chlorpheniramine is a potent first-generation histamine H1 receptor antagonist that can increase action potential duration and induce QT prolongation in several animal models. Since block of cardiac human ether-a-go-go-related gene (hERG) channels is one of leading causes of acquired long QT syndrome, we investigated the acute effects of chlorpheniramine on hERG channels to determine the electrophysiological basis for its proarrhythmic potential. We examined the effects of chlorpheniramine on... -
Multiple Residues in the P-Region and M2 of Murine Kir 2.1 Regulate Blockage by External Ba2＋
YoungMeeLee, GarethA.Thompson, IanAshmole, MarkLeyl, InsukSo, PeterR.Stanfield 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2009, Vol.13 No.1 10 61-69 (9 pages)
Kir 2.1. We expressed mutant and wild type murine Kir 2.1 in Chinese hamster ovary (CHO) cells and used the whole cell patch-clamp technique to record K＋ currents in the absence and presence of externally applied Ba2＋. Wild type Kir2.1 was blocked by externally applied Ba2＋ in a voltage and concentration dependent manner. Mutants of Y145 in the selectivity filter showed little change in the kinetics of Ba2＋ blockage. The estimated Kd(0) was 108ՌM for Kir2.1 wild type, 124ՌM for a... -
Neurovascular Mechanisms in Stroke, Neurodegeneration and Recovery
EngH.Lo 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2006, Vol.10 No.5 1 223-230 (8 pages)
The emerging concept of the“neurovascular unit”may enable a powerful paradigm shift for neuroscience. Instead of a pure focus on the“neurobiology”of disease, an opportunity now exists to return to a more integrative approach. The neurovascular unit emphasizes that signaling between vascular and neuronal compartments comprise the basis for both function and dysfunction in brain. Hence, brain disorders are not just due to death of neurons, but instead manifested as cell signaling perturbations... -
PKA-Mediated Regulation of B/K Gene Transcription in PC12 Cells
Mi-HyunChoi, Ho-ShikKim, Sung-HoChoi, Mi-YoungKim, Yoon-SeongJang, Young-MinJang, Jeong-HwaLee, Seong-WhanJeong, In-KyungKim, Oh-JooKwon 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2005, Vol.9 No.6 4 333-340 (8 pages)
B/K protein is a novel protein containing double C2-like domains. We examined the specific signaling pathway that regulates the transcription of B/K in PC12 cells. When the cells were treated with forskolin (50μM), B/K mRNA and protein levels were time-dependently decreased, reaching the lowest level at 3 or 4 hr, and thereafter returning to the control level. Chemicals such as dibutyryl-cAMP, cell- permeable cyclic AMP (cAMP) analogue and CGS21680, adenosine receptor A2A agonist, also... -
Intrinsic Gating in Inward Rectifier Potassium Channels (Kir2.1) with Low Polyamine Affinity Generated by Site Directed Mutagenesis
ISo, , IAshmole, HSoh, CSPark, PJSpencer, MLeyl, PRStanfield, 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 12 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2003, Vol.7 No.3 3 131-142 (12 pages)
wild type. This inward rectification occurs with a reduced affinity for spermine and persists in the absence of polyamines. Though the unitary current-voltage relation shows some inward rectification, it is insufficient to account for that seen under whole cell recording. Channels open and shut under single channel recording, and changes of Popen appear to generate inward rectification. In D172H, the reduction in affinity for spermine is greater when His is protonated at low pHi. The effective... -
Normal Anxiety, Fear and Depression-related Behaviors in Mice Lacking α-Calcitonin Gene-Related Peptide
JonghoLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2002, Vol.6 No.6 4 299-304 (6 pages)
to the mice behaviors. αCGRP-knockout mice performed equally as well as wild type mice in the light-dark transition test and in the elevated plus maze test of anxiety. αCGRP-null mice behaved similarly as wild-type mice in the Porsolt swim test of depression. They also exhibited normal learning and memory in the fear conditioning tasks. It is concluded that αCGRP is not essential for mice to be able to perform these tests, despite the presence of αCGRP in the relevant regions of the brain.
