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1041.

p38 MAPK Participates in Muscle-Specific RING Finger 1-Mediated Atrophy in Cast-Immobilized Rat Gastrocnemius Muscle

JunghwanKim, Kyung-JongWon, HwanMyungLee, Byong-YongHwang, Young-MinBae, WhanSooChoi, HyukSong, KiWonLim, Chang-KwonLee, BokyungKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2009, Vol.13 No.6 13 491-496 (6 pages)

JunghwanKim, Kyung-JongWon, HwanMyungLee, Byong-YongHwang, Young-MinBae, WhanSooChoi, HyukSong, KiWonLim, Chang-KwonLee, BokyungKim 저
...
- 3,000원
Skeletal muscle atrophy is a common phenomenon during the prolonged muscle disuse caused by cast immobilization, extended aging states, bed rest, space flight, or other factors. However, the cellular mechanisms of the atrophic process are poorly understood. In this study, we investigated the involvement of mitogen-activated protein kinase (MAPK) in the expression of muscle-specific RING finger 1 (MuRF1) during atrophy of the rat gastrocnemius muscle. Histological analysis revealed that cast...
1042.

Nitric Oxide Modulation of GABAergic Synaptic Transmission in Mechanically Isolated Rat Auditory Cortical Neurons

Jong-JuLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2009, Vol.13 No.6 9 461-467 (7 pages)

Jong-JuLee 저
...
- 3,000원
The auditory cortex (A1) encodes the acquired significance of sound for the perception and interpretation of sound. Nitric oxide (NO) is a gas molecule with free radical properties that functions as a transmitter molecule and can alter neural activity without direct synaptic connections. We used whole-cell recordings under voltage clamp to investigate the effect of NO on spontaneous GABAergic synaptic transmission in mechanically isolated rat auditory cortical neurons preserving functional...
1043.

The Antinociceptive Effect of Sigma-1 Receptor Antagonist, BD1047, in a Capsaicin Induced Headache Model in Rats

YoungBaeKwon, YoungChanJeong, JungKeeKwon, JiSeonSon, KeeWonKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 5 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2009, Vol.13 No.6 3 425-429 (5 pages)

YoungBaeKwon, YoungChanJeong, JungKeeKwon, JiSeonSon, KeeWonKim 저
...
- 1,500원
Intracranial headaches, including migraines, are mediated by nociceptive activation of the trigeminal nucleus caudalis (TNC), but the precise mechanisms are poorly understood. We previously demonstrated that selective blockage of spinal sigma-1 receptors (Sig-1R) produces a prominent antinociceptive effect in several types of pain models. This study evaluates whether the Sig-1R antagonist (BD1047) has an antinociceptive effect on capsaicin (a potent C-fiber activator) induced headache models in...
1044.

Social Isolation Selectively Increases Anxiety in Mice without Affecting Depression-like Behavior

ChuljungKwak, Sue-HyunLee, Bong-KiunKaang 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 4 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2009, Vol.13 No.5 4 357-360 (4 pages)

ChuljungKwak, Sue-HyunLee, Bong-KiunKaang 저
...
- 1,500원
number of environmental factors affect animals' behavior. Without controlling these variables, it is very hard for researchers to get not only reliable, but replicable data from various behavioral experiments testing animals' cognitive as well as emotional functions. For example, laboratory mice which had restricted environment showed different synaptic potentiation properties with wild mice (Zhao MG et al., 2009). While performing behavioral experiments, however, it is sometimes inevitable that...
1045.

Increase of NADPH-diaphorase Expression in Hypothalamus of Stat4 Knockout Mice

MeeSookHong, JeongYoonSong, DongHwanYun, Jeong-JeCho, Joo-HoChung 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 5 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2009, Vol.13 No.5 1 337-341 (5 pages)

MeeSookHong, JeongYoonSong, DongHwanYun, Jeong-JeCho, Joo-HoChung 저
...
- 1,500원
Signal transducer and activator of transcription 4 (STAT4), a STAT family member, mediates interleukin 12 (IL12) signal transduction. IL12 is known to be related to calorie-restricted status. In the central nervous system, IL12 also enhances the production of nitric oxide (NO), which regulates food intake. In this study, the expression of neuronal NO synthase (Nos1), which is also related to food intake, was investigated in the hypothalamic areas of Stat4 knockout (KO) mice using nicotinamide...
1046.

Antioxidant Effect of CoQ10 on N-nitrosodiethylamine-induced Oxidative Stress in Mice

HoSunSong, HeeRaeKim, TaeWookPark, BongJaeCho, MiYoungChoi, ChangJongKim, UyDongSohn, SangSooSim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2009, Vol.13 No.4 9 321-326 (6 pages)

HoSunSong, HeeRaeKim, TaeWookPark, BongJaeCho, MiYoungChoi, ChangJongKim, UyDongSohn, SangSooSim 저
...
- 3,000원
The antioxidant effect of CoQ10 on N-nitrosodiethylamine (NDEA)-induced oxidative stress was investigated in mice. Food intake and body weight were similar in both CoQ10 and control groups during the 3-week experimental period. NDEA significantly increased the activities of typical marker enzymes of liver function (AST, ALT and ALP) both in control and CoQ10 groups. However, the increase of plasma aminotransferase activity was significantly reduced in the CoQ10 group. Lipid peroxidation in...
1047.

Inhibition of Arterial Myogenic Responses by a Mixed Aqueous Extract of Salvia Miltiorrhiza and Panax Notoginseng (PASEL) Showing Antihypertensive Effects

EunBokBaek, HaeYoungYoo, SuJungPark, Young-ShinChung, Eun-KyungHong, SungJoonKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2009, Vol.13 No.4 4 287-293 (7 pages)

EunBokBaek, HaeYoungYoo, SuJungPark, Young-ShinChung, Eun-KyungHong, SungJoonKim 저
...
- 3,000원
The dried roots of Danshen (Salvia miltiorrhiza) and Sanchi (Panax notoginseng) have been widely used in traditional Chinese medicine for promoting blood circulation as well as various other bodily functions. Here we investigated the effects of a mixture of aqueous extracts of Danshen and Sanchi, named PASEL, on blood pressure and vascular contractility in rats. Orally administered PASEL (62.5 mg/kg and 250 mg/kg, for 5 weeks) lowered the blood pressure of spontaneous hypertensive rats (SHR) but...
1048.

Kainic Acid-induced Neuronal Death is Attenuated by Aminoguanidine but Aggravated by L-NAME in Mouse Hippocampus

Jong-SeonByun, Sang-HyunLee, Seong-HoJeon, Yong-SooKwon, HeeJaeLee, Sung-SooKim, Young-MyeongKim, Myong-JoKim, WanjooChun 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2009, Vol.13 No.4 1 265-271 (7 pages)

Jong-SeonByun, Sang-HyunLee, Seong-HoJeon, Yong-SooKwon, HeeJaeLee, Sung-SooKim, Young-MyeongKim, Myong-JoKim, WanjooChun 저
...
- 3,000원
Nitric oxide (NO) has both neuroprotective and neurotoxic effects depending on its concentration and the experimental model. We tested the effects of NG-nitro-L-arginine methyl ester (L-NAME), a nonselective nitric oxide synthase (NOS) inhibitor, and aminoguanidine, a selective inducible NOS (iNOS) inhibitor, on kainic acid (KA)-induced seizures and hippocampal CA3 neuronal death. L-NAME (50 mg/kg, i.p.) and/or aminoguanidine (200 mg/kg, i.p.) were administered 1 h prior to the...
1049.

Role of T-type Ca2＋ Channels in the Spontaneous Phasic Contraction of Pregnant Rat Uterine Smooth Muscle

Si-EunLee, Duck-SunAhn, Young-HoLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2009, Vol.13 No.3 15 241-249 (9 pages)

Si-EunLee, Duck-SunAhn, Young-HoLee 저
...
- 3,000원
Although extracellular Ca2＋ entry through the voltage-dependent Ca2＋ channels plays an important role in the spontaneous phasic contractions of the pregnant rat myometrium, the role of the T-type Ca2＋ channels has yet to be fully identified. The aim of this study was to investigate the role of the T-type Ca2＋ channel in the spontaneous phasic contractions of the rat myometrium. Spontaneous phasic contractions and [Ca2＋]i were measured simultaneously in the longitudinal strips of female...
1050.

Flavone Attenuates Vascular Contractions by Inhibiting RhoA/Rho Kinase Pathway

InjiBaek, SuBunJeon, Min-JiSong, EnyueYang, UyDongSohn, InKyeomKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2009, Vol.13 No.3 10 201-207 (7 pages)

InjiBaek, SuBunJeon, Min-JiSong, EnyueYang, UyDongSohn, InKyeomKim 저
...
- 3,000원
Our previous study demonstrated that flavone inhibits vascular contractions by decreasing the phosphorylation levelof the myosin phosphatase target subunit (MYPT1). In the present study, we hypothesized that flavone attenuates vascular contractions through the inhibition of the RhoA/Rho kinase pathway. Rat aortic rings were denuded of endothelium, mounted in organ baths, and contracted with either 30 nM U46619 (a thromboxane A2 analogue) or 8.0 mM NaF 30 min after pretreatment with either...

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