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1061.

Mechanism of Membrane Hyperpolarization by Extracellular K+ in Resistance-sized Cerebral Arterial Muscle Cell of Rabbit

SeHoonKim, KunMooChoi, HoeSukKim, ByeongHwaJeon, SeokJongChang 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 10 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1999, Vol.3 No.1 1 1-10 (10 pages)

SeHoonKim, KunMooChoi, HoeSukKim, ByeongHwaJeon, SeokJongChang 저
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- 3,000원
in the cerebral resistant arteriole from rabbit. Single cells were isolated from the cerebral resistant arteriole, and using voltage-clamp technique barium-sensitive K⁢ currents were recorded, and their characteristics were observed. Afterwards, the changes in membrane potential and currents through the membrane caused by the change in [K⁢]o was observed. In the smooth muscle cells of cerebral resistant arteriole, ion currents that are blocked by barium, 4-aminopyridine (4-AP), and...
1062.

The Effects of Intracellular Monocarboxylates on the ATP-sensitive Potassium Channels in Rabbit Ventricular Myocytes

NariKim, JinHan, Eui-YongKim, Won-KyungHo, YungE.Earm 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1998, Vol.2 No.5 6 581-589 (9 pages)

NariKim, JinHan, Eui-YongKim, Won-KyungHo, YungE.Earm 저
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- 3,000원
isolated rabbit ventricular myocytes. Single channel currents of KATP channels were recorded using the excised inside-out or permeabilized attached (open-cell) patch-clamp technique at room temperature. Intracellular application of acetate, formate and pyruvate led to an inhibition of channel activity, whereas intracellular application of lactate increased channel activity. These effects were reversible upon washout. Analysis of single channel kinetics showed that monocarboxylates did not affect...
1063.

Effects of Exogenous ATP on Calcium Mobilization and Cell Proliferation in C6 Glioma Cell

Eun-JungLee, SeokHoCha, WoonKyuLee, Kweon-HaengLee, Sang-BokLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1998, Vol.2 No.4 3 419-425 (7 pages)

Eun-JungLee, SeokHoCha, WoonKyuLee, Kweon-HaengLee, Sang-BokLee 저
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- 3,000원
a dose-dependent manner (10⁣7 M∼10⁣3 M). ATP-induced [Ca2⁢]i increases were slightly slowed in extracellular calcium-free conditions especially in sustained phase. ATP-induced [Ca2⁢]i increment was also inhibited by the pretreatment of U73122, a phospholipase C (PLC) inhibitor, in a time-dependent manner. Suramin, a putative P2Y receptor antagonist, dose-dependently weakened ATP-induced [Ca2⁢]i mobilization. Significant increases in cell proliferation were observed...
1064.

In Vitro Cytotoxicity of Novel Platinum(II) Coordination Complexes Containing Diaminocyclohexane and Diphenylphosphines

Jee-ChangJung, Young-KyuKim, Seung-JoonPark, Joo-HoChung, Sung-GooChang, Kyung-TaeLee, Min-SonBaek, Jong-JipPark, Young-SooRho 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1998, Vol.2 No.3 15 395-401 (7 pages)

Jee-ChangJung, Young-KyuKim, Seung-JoonPark, Joo-HoChung, Sung-GooChang, Kyung-TaeLee, Min-SonBaek, Jong-JipPark, Young-SooRho 저
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- 3,000원
We have synthesized new platinum(II) analogs containing 1,2-diaminocyclohexane (dach) as a carrier ligand, 1,3-bis(diphenylphosphino) propane (DPPP) /1,2-bis(diphenylphosphino)ethane (DPPE) as a leaving group and nitrates to improve solubility. In the present study, the cytotoxicity of [Pt(trans-l-dach)(DPPP)]·2NO3 (KHPC-001) and [Pt(trans-l-dach)(DPPE)]·2NO3 (KHPC-002) was evaluated and compared on various P-388 cancer cell lines and porcine kidney cell line (LLC-PK1). The new platinum...
1065.

Influence of Glucocorticoids on Cholinergic Stimulation-Induced Catecholamine Secretion from the Rat Adrenal Medulla

Dong-YoonLim, Jae-JoonLee, Oh-SeongGweon 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 12 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1998, Vol.2 No.2 5 173-184 (12 pages)

Dong-YoonLim, Jae-JoonLee, Oh-SeongGweon 저
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- 4,100원
a dose-dependent inhibition in CA secretion evoked by ACh (5.32 mM), excess K+ (a membrane-depolarizor 56 mM), DMPP (a selective nicotinic receptor agonist, 100 ՌM for 2 min), McN-A-343 (a muscarinic receptor agonist, 100 ՌM for 4 min), Bay-K-8644 (a calcium channel activator, 10 ՌM for 4 min) and cyclopiazonic acid (a releaser of intracellular Ca2+, 10 ՌM for 4 min). Similarly, the preperfusion of hydrocortisone (30 ՌM) for 20 min also attenuated significantly the...
1066.

사람 Neuroblastoma SH-SY5Y 세포주에서 Opiate 내성에 의한 c-myc 유전자 표현 The c-myc Expression on the Opioid Tolerance in Human Neuroblastoma SH-SY5Y Cells

김수경, 박창교, 권지윤, 서성일, Soo-kyungKim, Chang-kyoPark, Gee-younKwon, Sung-ilSuh 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1997, Vol.1 No.6 10 691-697 (7 pages)

김수경, 박창교, 권지윤, 서성일, Soo-kyungKim, Chang-kyoPark, Gee-younKwon, Sung-ilSuh 저
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- 3,000원
a dose-dependent manner (5, 10, 15, and 20 ㄍM). On the other hand, the chronic treatment of morphine (10 ㄍM for six days) did not induce the elevated expression of c-myc mRNA. The c-myc expression was slightly inhibited in comparison with that of the acute morphine response. However, cAMP concentrations were increased with regard to morphine withdrawal response. These results suggest that the alterations in c-myc expression might imply a significant opiate regulation relating to...
1067.

Endothelin Increases Intracellular Free Calcium in Isolated Rat Nephron

SeokHoCha, Young-JinCho, Kweon-HaengLee, HitoshiEndou 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1997, Vol.1 No.5 12 565-572 (8 pages)

SeokHoCha, Young-JinCho, Kweon-HaengLee, HitoshiEndou 저
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- 3,000원
rat nephron, the effect of endothelin-1, -2 and -3 (ET-1, -2 and -3) on cytosolic free calcium concentration ([Ca2⁢]i) was determined using the fluorescent indicator Fura-2/AM. [Ca2⁢]i increase was investigated in 9 parts of the single nephron including glomerulus (Glm), S1, S2, S3, cortical and medullary thick ascending limb and cortical (CCT) and outer medullary collecting tubule (OMCT). Endothelins increased [Ca2⁢]i in Glm (ET-1; 127±17%, ET-2; 93±5%, ET-3; 169±17%), CCT...
1068.

Altered Vascular Calcium Regulation in Hypertension

Won-jaeKim, Jong-unLee, YongHyunPark, SangChaeNam 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1997, Vol.1 No.5 8 529-535 (7 pages)

Won-jaeKim, Jong-unLee, YongHyunPark, SangChaeNam 저
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- 3,000원
The present study was aimed at investigating whether the vascular calcium regulation is altered in hypertension. Two-kidney, one clip (2K1C) and deoxycorticosterone acetate (DOCA)-salt hypertension were made in rats, and their thoracic aortae were taken 4 weeks later. The isometric contractile response and calcium uptake of the endothelium-denuded aortic preparations were determined. Caffeine (0.1∼35 mmol/L) induced a greater contraction in 2K1C and DOCA-salt hypertension than in normotensive...
1069.

Effects of Ginsenosides on the Mechanism of Histamine Release in the Guinea Pig Lung Mast Cells Activated by Specific Antigen- Antibody Reactions

JaiYoulRo, YoungSooAhn, KyungHwanKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 12 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1997, Vol.1 No.4 11 445-456 (12 pages)

JaiYoulRo, YoungSooAhn, KyungHwanKim 저
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- 4,100원
the dose-dependent manner in the pretreatment of Rb2, but Re pretreatment facilitated the increased PLD activity during mast cell activation. The amount of DAG produced by phospholipase C (PLC) activity was decreased by Rb2 pretreatment, but Re pretreatment was not affected. The amount of mass DAG was decreased by Rb2 and Re pretreatment during mast cell activation. The data suggest that Rb2 purified from Korean Red Ginseng Radix inhibits the DAG which is produced by the activation of mast cells...
1070.

Two Types of Voltage-dependent Outward Potassium Currents in Smooth Muscle Cells of Rabbit Basilar Atery

TongMookKang, InsukSo, DaeYongUhm, KiWhanKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 15 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1997, Vol.1 No.2 7 169-183 (15 pages)

TongMookKang, InsukSo, DaeYongUhm, KiWhanKim 저
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- 4,400원
in single smooth muscle cells (SMCs) isolated from rabbit basilar artery, and investigated the characteristics of them. The time-courses of activation were well fitted by exponential function raised to second power (n2) in IK(v) and fourth power (n4) in Ito. The activation, inactivation and recovery time courses of Ito were much faster than that of IK(V). The steady-state activation and inactivation of IK(V) was at the more hyperpolarized range than that of Ito contrary to the reports in other...

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