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전체 선택해제
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Role of NF-κB Binding Sites in the Regulation of Inducible Nitric Oxide Synthase by Tyrosine Kinase
YoungSueRyu, JangHeeHong, JongHoLim, SoHyunBae, IhnSubAhn, JeongHoSeok, JaeHeunLee, GangMinHur 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2001, Vol.5 No.1 8 55-63 (9 pages)
In macrophages, lipopolysaccharide (LPS) alone or in combination with interferon-γ (IFN-γ) has been shown to release a nitric oxide (NO) through the increase of the transcription of the inducible nitric oxide synthase (iNOS) gene. To investigate the exact intracellular signaling pathway of the regulation of iNOS gene transcription by LPS plus IFN-γ, the effects of protein tyrosine kinase (PTK) inhibitor and protein kinase C (PKC) inhibitors on NO production, iNOS mRNA expression, nuclear... -
Role of Gap Junctions in the Endothelium-Dependent Hyperpolarization of Vascular Smooth Muscle Cells
YoshimichiYamamoto, MeganF.Klemm, HikaruHashitani, RichardJ.Lang, TsuyoshiSoji, HikaruSuzuki 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2001, Vol.5 No.1 1 1-8 (8 pages)
distribution of the dye to surrounding cells including smooth muscle cells. These observations allow the speculation that myoendothelial gap junctions may have a functional significance. Simultaneous measurement of the electrical responses in both endothelial and smooth muscle cells using the double patch clamp method demonstrates that these two cell types are indeed electrically coupled, indicating that they behave as a functional syncytium. The EDHF-induced hyperpolarization is produced by an... -
Cadmium Inhibition of Renal Endosomal Acidification
MooSeongKim, KyoungRyongKim, DoWhanAhn, YangSaengPark 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 10 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2000, Vol.4 No.1 9 63-72 (10 pages)
Chronic exposure to cadmium (Cd) results in an inhibition of protein endocytosis in the renal proximal tubule, leading to proteinuria. In order to gain insight into the mechanism by which Cd impairs the protein endocytosis, we investigated the effect of Cd on the acidification of renal cortical endocytotic vesicles (endosomes). The endosomal acidification was assessed by measuring the pH gradient-dependent fluorescence change, using acridine orange or FITC-dextran as a probe. In renal endosomes... -
Effect of Ethanol on Na+-Pi Uptake in Opossum Kidney Cells Role of Membrane Fluidization and Reactive Oxygen Species
InHoPark, MoonYoungHwang, JaeSukWoo, JinSupJung, YongKeunKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 10 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1999, Vol.3 No.5 10 529-538 (10 pages)
This study was undertaken to examine the effect of ethanol on Na-dependent phosphate (Na-Pi) uptake in opossum kidney (OK) cells, an established renal proximal tubular cell line. Ethanol inhibited Na-dependent component of phosphate uptake in a dose-dependent manner with I50 of 8.4%, but it did not affect Na-independent component. Similarly, ethanol inhibited Na-dependent uptakes of glucose and amino acids (AIB, glycine, alanine, and leucine). Microsomal... -
Temporal Changes in Neuronal Activity of the Bilateral Medial Vestibular Nuclei Following Unilateral Labyrinthectomy in Rats
ByungRimPark, MoonYoungLee, MinSunKim, SungHoLee, HanJoNa, NamYongDoh 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 10 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1999, Vol.3 No.5 4 481-490 (10 pages)
To investigate the changes in the responses of vestibular neurons with time during vestibular compensation, the resting activity and dynamic responses of type I and II neurons in the medial vestibular nuclei to sinusoidal angular acceleration were recorded following unilateral labyrinthectomy (ULX) in Sprague-Dawley rats. The unitary extracellular neuronal activity was recorded from the bilateral medial vestibular nuclei with stainless steel microelectrodes of 3∼5 MΩ before ULX, and 6, 24,... -
Role of Phospholipase A2 in Oxidant-induced Alteration in Phosphate Transport in Primary Cultured Rabbit Renal Proximal Tubule Cells
KwonMooPark, SunHeeKo, JaeSukWoo, JinSupJung, SangHoLee, YongKeunKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1998, Vol.2 No.5 8 601-609 (9 pages)
The present study was undertaken to examine the role of phospholipase A2 (PLA2) in oxidant-induced inhibition of phosphate transport in primary cultured rabbit renal proximal tubule cells. Uptakes of phosphate and glucose were dose-dependently inhibited by an oxidant t-butylhydroperoxide (tBHP), and the significant inhibition appeared at 0.025 mM of tBHP, whereas tBHP-induced alterations in lipid peroxidation and cell viability were seen at 0.5 mM. tBHP stimulated arachidonic acid (AA) release... -
Tetrachloroauric Acid Depresses the Activation Processes of Phagocytic Cells
ChungSooLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1998, Vol.2 No.3 13 377-384 (8 pages)
Gold compounds depress phagocytic cell responses, including chemotaxis, and respiratory burst. However, the effects of gold compounds on the function of phagocytic cells are variable according to the preparation of medicine. In this study, effect of tetrachloroauric acid on activated neutrophil responses, including respiratory burst, lysosomal enzyme release and change of intracellular Ca2+ level and on the synthesis of interleukin-8 and granulocyte-macrophage colony stimulating factor by... -
Hydroxyl Radical-Mediated Commitment of HL-60 Cells to Differentiation Modulation of Differentiation Process by Phosphodiesterase Inhibitors
YoungJinCho, WoongShickAhn, SeokHoCha, Kweon-HaengLee, WonIlKim, MyungHeeChung 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1998, Vol.2 No.3 12 369-376 (8 pages)
This report shows that hydroxyl radical, generated by a Fenton reaction involving adenosine 5'-diphosphate/Fe2+ complex (5-15 ㄍM) and H2O2 (2 ㄍM), induced differentiation of HL-60 cells in a dose- and time-dependent manner. This is evidenced by the increases in 12-O-tetradecanoylphorbol 13-acetate- and fMLP-stimulated superoxide production capability. The cells exposed to hydroxyl radical for defined periods (24∼96 hr) continued to differentiate even after the hydroxyl radical... -
Characteristics of Ca2+ Stores in Rabbit Cerebral Artery Myocytes
SungJoonKim, JinKyungKim, InsukSo, SukHyoSuh, SangJinLee, KiWhanKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 10 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1998, Vol.2 No.3 6 313-322 (10 pages)
Ca2-binding fluorescent dye, fura-2. Histamine (5 ㄍM) or caffeine (10 mM) induced a phasic rise of cytoplasmic free Ca2 concentration ([Ca2]c) which could occur repetitively with extracellular Ca2 but only once or twice in Ca2-free bathing solution. Also, the treatment with inhibitor of sarcoplasmic reticulum Ca2-ATPase suppressed the rise of [Ca2]c by histamine or caffeine. In Ca2-free bathing solution, short application of caffeine...
