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101.

Cooperation of Gβ and Gαq Protein in Contractile Response of Cat Lower Esophageal Sphincter (LES)

UyDongSohnTaiSangLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2003, Vol.7 No.6 9 349-355 (7 pages)

UyDongSohnTaiSangLee 저
...
- 3,000원
We previously shown that LES contraction depends on M3 receptors linked to PTX insensitive Gq protein and activation of PLC. This results in production of IP3, which mediates calcium release, and contraction through a CaM dependent pathway. In the esophagus ACh activates M2 receptors linked to PTX sensitive Gi3 protein, resulting in activation of PLD, presumably, production of DAG. We investigated the role of PLC isozymes which can be activated by Gq or Gβ protein on ACh-induced contraction in...
102.

Salicylate Regulates Cyclooxygenase-2 Expression through ERK and Subsequent NF-κB Activation in Osteoblasts

Han-JungChae, Jun-KiLee, Joung-OukByun, Soo-WanChae, Hyung-RyongKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2003, Vol.7 No.4 8 239-246 (8 pages)

Han-JungChae, Jun-KiLee, Joung-OukByun, Soo-WanChae, Hyung-RyongKim 저
...
- 3,000원
The expression of cyclooxygenase-2 (COX-2) is a characteristic response to inflammation and can be inhibited with sodium salicylate. TNF-α plus IFN-γ can induce extracellular signal-regulated kinase (ERK), IKK, IκB degradation and NF-κB activation. The inhibition of the ERK pathway with selective inhibitor, PD098059, blocked cytokine-induced COX-2 expression and PGE2 release. Salicylate treatment inhibited COX-2 expression induced by TNF-α/IFN-γ and regulated the activation of ERK, IKK and...
103.

Sympathetic Regulation of Aquaporin Water Channels in Rat Kidney

JongUnLee, KwangjayYoo, YoonWhaOh, DongYoonLim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 5 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2003, Vol.7 No.3 10 181-185 (5 pages)

JongUnLee, KwangjayYoo, YoonWhaOh, DongYoonLim 저
...
- 1,500원
Whether there exists a sympathetic neural regulation on the aquaporin (AQP) channels in the kidney was examined. Male Sprague-Dawley rats were used. They were renal nerve denervated by stripping the nervous and connective tissues passing along the renal artery and vein, and painting these vessels with 10% phenol solution through a midline abdominal incision. Three days later, the expression of AQP1-4 proteins in the denervated kidneys was determined. The content of norepinephrine was found...
104.

Mechanism of Glutamate-induced [Ca2+]i Increase in Substantia Gelatinosa Neurons of Juvenile Rats

SungJunJung, JeongSookChoi, JiyeonKwak, JunKim, JongWhanKim, SangJeongKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 5 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2003, Vol.7 No.2 1 53-57 (5 pages)

SungJunJung, JeongSookChoi, JiyeonKwak, JunKim, JongWhanKim, SangJeongKim 저
...
- 1,500원
by CNQX, an AMPA receptor blocker, but not by AP-5, a NMDA receptor blocker. The glutamate-induced [Ca2⁢]i increase in Ca2⁢ free condition was not affected by iGluR blockers. A selective mGluR (group I) agonist, RS-3,5-dihydroxyphenylglycine (DHPG), induced [Ca2⁢]i increase at holding potential of ⁣70 mV in SG neurons. These findings suggest that the glutamate-induced [Ca2⁢]i increase is associated with AMPA-sensitive iGluR and group I mGluR in SG neurons of rats.
105.

Effects of Noradrenaline on the Membrane Potential of Prostatic Neuroendocrine Cells of Rat

JunHeeKim, SunYoungShin, Dae-YongUhm, SungJoonKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2003, Vol.7 No.1 9 47-52 (6 pages)

JunHeeKim, SunYoungShin, Dae-YongUhm, SungJoonKim 저
...
- 3,000원
The prostate gland contains numerous neuroendocrine cells that are believed to influence the function of the prostate gland. Our recent study demonstrated the expression of both α1- and α2-ARs, signaling the release of stored Ca2⁢ and the inhibition of N-type Ca2⁢ channels, respectively, in rat prostate neuroendocrine cells (RPNECs). In this study, the effects of NA on the resting membrane potential (RMP) of RPNECs were investigated using a whole-cell patch clamp method. Fresh...
106.

Ceramide is involved in MPP+-induced Cytotoxicity in Human Neuroblastoma Cells

Eun-JooNam, Hye-SookLee, YoungJaeLee, Wan-SeokJoo, SunghoMaeng, Hye-InIm, Chan-WoongPark, YongSikKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2002, Vol.6 No.6 1 281-286 (6 pages)

Eun-JooNam, Hye-SookLee, YoungJaeLee, Wan-SeokJoo, SunghoMaeng, Hye-InIm, Chan-WoongPark, YongSikKim 저
...
- 3,000원
To understand the cytotoxic mechanism of MPP⁢, we examined the involvement of ceramide in MPP⁢- induced cytotoxicity to human neuroblastoma SH-SY5Y cells. When SH-SY5Y cells were exposed to MPP⁢, MPP⁢ induced dose-dependent cytotoxicity accompanied by 2-fold elevation of intracellular ceramide levels in SH-SY5Y cells. Three methods were used to test the hypothesis that the elevated intracellular ceramide is related to MPP⁢-induced cytotoxicity: C2-ceramide was...
107.

A Role of Mitogen Activated Protein Kinases and Inflammatory Responses in Gender Differences in Kidney Ischemia Injury

KwonMooParkHoJaeHan 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2002, Vol.6 No.3 5 155-160 (6 pages)

KwonMooParkHoJaeHan 저
...
- 3,000원
It is not known whether gender differences play a role in susceptibility to ischemic acute renal failure. Thus, we examined if there were any differences in susceptibility between male and female mice to kidney ischemic injury, and if so, whether it is due to differences in mitogen activated protein kinases (MAPKs) or inflammatory responses to ischemia. Female mice were protected against kidney ischemia when compared with males. Thirty minutes of bilateral ischemia resulted in marked functional...
108.

Modulation of L-type Ca2+ Channel Currents by Various Protein Kinase Activators and Inhibitors in Rat Clonal Pituitary GH3 Cell Line

YoungMinBae, Hye-JungBaek, HanaCho, YungEEarm, Won-KyungHo 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2001, Vol.5 No.2 4 139-146 (8 pages)

YoungMinBae, Hye-JungBaek, HanaCho, YungEEarm, Won-KyungHo 저
...
- 3,000원
L-type Ca2⁢ channels play an important role in regulating cytosolic Ca2⁢ and thereby regulating hormone secretions in neuroendocrine cells. Since hormone secretions are also regulated by various kinds of protein kinases, we investigated the role of some kinase activators and inhibitors in the regulation of the L-type Ca2⁢ channel currents in rat pituitary GH3 cells using the patch-clamp technique. Phorbol 12,13-dibutyrate (PDBu), a protein kinase C (PKC) activator, and...
109.

The Role of Lipid Peroxidation and Glutathione on the Glycochenodeoxycholic Acid-Induced Cell Death in Primary Cultured Rat Hepatocytes

SangHuiChu, WolMiPark, KyungEunLee, YoungSookPae 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2000, Vol.4 No.2 6 121-127 (7 pages)

SangHuiChu, WolMiPark, KyungEunLee, YoungSookPae 저
...
- 3,000원
acid (GCDC; 0∼400μM) for 3 hours. In electron microscopic examination and agarose gel electrophoresis, low concentration of GCDC treatment mainly induced apoptotic feature. Whereas 400μM GCDC treated cells demonstrated both apoptosis and necrosis. Lipid peroxidation was increased dose- dependently in GCDC treated hepatocyte. And this was also accompanied by decreased glutathione. Therefore, oxygen free radical damage may play a partial role in GCDC-induced hepatic cell death.
110.

Lipid Peroxidation, NF-κB Activation and Cytokine Production in Neutrophil-Stimulated Pancreatic Acinar Cells

HyeyoungKim, JeongYeonSeo, SeHaengCho, KyungHwanKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1999, Vol.3 No.5 9 521-528 (8 pages)

HyeyoungKim, JeongYeonSeo, SeHaengCho, KyungHwanKim 저
...
- 3,000원
Reactive oxygen species (ROS), generated by infiltrating neutrophils, are considered as an important regulator in the pathogenesis and deveolpment of pancreatitis. The present study aims to investigate whether neutrophils primed by 4β-phorbol 12β-myristate 13α-acetate (PMA) affect the productions H2O2 and lipid peroxide (LPO), NF-κB activation and cytokine production in pancreatic acinar cells, and whether these alterations were inhibited by an antioxidant, N-acetylcysteine (NAC) and...

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