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c-fos mRNA Expression in the Vestibular System following Hypergravity Stimulation in Rats
GuangShiJin, JaeHyoLee, JaeHeeLee, MoonYoungLee, MinSunKim, YuanZheJin, JeongHoonSong, ByungRimPark 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2007, Vol.11 No.1 1 1-7 (7 pages)
Altered environmental gravity, including both hypo- and hypergravity, may result in space adaptation syndrome. To explore the characteristics of this adaptive plasticity, the expression of immediate early gene c-fos mRNA in the vestibular related tissues following an exposure to hypergravity stimulus was determined in rats. The animals were subjected to a force of 2 g (twice earth's gravity) for 1, 3, or 12 h, and were examined poststimulus at 0, 2, 6, 12, and 24 h. RT-PCR (reverse transcription... -
Estrogen Pretreatment of Organotypic Hippocampal Slices Protects Neurons against Oxygen-Glucose Deprivation with Akt Activation
Eun-MiPark, SunghuiHong, Kyung-EunLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2006, Vol.10 No.3 2 123-130 (8 pages)
In several experimental models, estrogens protect neurons against ischemic insults. However, the recent clinical studies of hormone replacement showed negative results to prevent stroke. Therefore, optimal models to study estrogen replacement for neuroprotection are needed before its clinical application. Organotypic hippocampal slice under oxygen-glucose deprivation (OGD) has been established as a model of cerebral ischemia and has advantages to study drug effects. We investigated whether... -
Calcium Ion Dynamics after Dexamethasone Treatment in Organotypic Cultured Hippocampal Slice
Hee-JungChae, Tong-HoKang, Ji-HoPark 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2005, Vol.9 No.6 8 363-370 (8 pages)
It is imperative to analyse brain injuries directly in real time, so as to find effective therapeutic compounds to protect brain injuries by stress. We established a system which could elucidate the real time Ca2 dynamics in an organotypic cultured hippocampal slice by the insults of artificial stress hormone, dexamethasone. The real time Ca2 dynamics could continuously be detected in cornus ammonis 3 (CA3) of the organotypic hippocampus for 8 hours under confocal microscopy. When... -
Effect of Extracts from Safflower Seeds on Osteoblastic Differentiation and Intracellular Free Calcium Concentration in MC3T3-E1 Cells
Hye-OckJang, Hyun-SupEom, Sung-BaeRoh, IlYun 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2005, Vol.9 No.1 8 55-62 (8 pages)
Very little research has been carried out on safflower seed for the prevention and treatment of the bone deficiency diseases, including osteoporosis, which are supported by scientific evidences. In the present study, 3μl of 0.1% dried crude extract or 2μl of 0.1% dried aqueous fraction were shown to significantly accelerate the rate of differentiation of osteoblast. Also, the crude extract and aqueous fraction increased the [Ca2]i of the cultured osteoblast cells: 3μl of 0.1% dried... -
D-Amphetamine Causes Dual Actions on Catecholamine Release from the Rat Adrenal Medulla
Geon-HanLim, Gwang-MoonNa, Seon-YoungMin, Yoo-SeokSeo, Chan-WonPark, Dong-YoonLim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 10 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2005, Vol.9 No.1 7 45-54 (10 pages)
The present study was designed to examine the effect of d-amphetamine on CA release from the isolated perfused model of the rat adrenal gland, and to establish its mechanism of action. D- amphetamine (10∼100μM), when perfused into an adrenal vein of the rat adrenal gland for 60 min, enhanced the CA secretory responses evoked by ACh (5.32⁓103 M), excess K (5.6⁓102 M, a membrane depolarizer), DMPP (104 M, a selective neuronal nicotinic Nn-receptor agonist)... -
Acetylcholine Induces Hyperpolarization Mediated by Activation of K(Ca) Channels in Cultured Chick Myoblasts
DoyunLee, JaeheeHan, Jae-YongPark 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2005, Vol.9 No.1 6 37-44 (8 pages)
open probability of KCa channels from 0.008 to 0.023, whereas muscarine failed to do so. Since the activity of KCa channel is sensitive to intracellular Ca2 level, nAChR seems to be capable of inducing Ca2 influx. Using the Ca2 imaging analysis, we were able to provide direct evidence that ACh induced Ca2 influx from extracellular solution, which was dramatically increased by valinomycin-mediated hyperpolarization. In addition, ACh hyperpolarized the membrane potenti... -
Physiological, Pharmacological and Toxicological Implications of Heterodimeric Amino Acid Transporters
YoshikatsuKanaiHitoshiEndou 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 12 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2004, Vol.8 No.3 1 117-128 (12 pages)
The heterodimeric amino acid transporter family is a subfamily of SLC7 solute transporter family which includes 14-transmembrane cationic amino acid transporters and 12-transmembrane heterodimeric amino acid transporters. The members of heterodimeric amino acid transporter family are linked via a disulfide bond to single membrane spanning glycoproteins such as 4F2hc (4F2 heavy chain) and rBAT (related to b0, -amino acid transporter). Six members are associated with 4F2hc and one is linked... -
Influence of Bradykinin on Catecholamine Release from the Rat Adrenal Medulla
Dong-YoonLim, Il-HwanKim, Gwang-MoonNa, Moo-JinKang, Ok-MinKim, Deok-HoChoi, Young-WooKi 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2003, Vol.7 No.4 7 231-238 (8 pages)
The present study was undertaken to investigate the effect of bradykinin on secretion of catecholamines (CA) evoked by stimulation of cholinergic receptors and membrane depolarization from the isolated perfused model of the rat adrenal glands, and to elucidate its mechanism of action. Bradykinin (3⁓108 M) alone produced a weak secretory response of the CA. however, the perfusion with bradykinin (3⁓108 M) into an adrenal vein of the rat adrenal gland for 90 min enhanced... -
The Staging of Major Mood Disorders
Ather Muneer, Rana Mazommil 대한신경정신의학회 Psychiatry Investigation 12 Pages
대한신경정신의학회 Psychiatry Investigation 2018, 제 15권 제 8호 2 747-758 (12 pages)
Objective_Staging of psychiatric disorders is gaining momentum and the purpose of this review is to examine whether major mood disorders can be defined according to stages. Methods_In April 2018 the PubMed electronic data base was scrutinized by a combination of various search terms like “major depressive disorder and staging,” “bipolar disorder and neuroprogression,” etc. To incorporate the latest findings the search was limited to the last 10 years. Both original and review articles were...
