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Inhibitory Effects of Corni Fructus Extract on Angiogenesis and Adipogenesis
Jae-HoHwang, Jong-DeogKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 10 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2011, Vol.15 No.1 7 43-52 (10 pages)
Natural products in Chonnam, Korea were screened via anti-angiogenesis experiments, and 1 candidate product was identified, Corni fructus, which exerted dose-dependent inhibitory effects against angiogenesis, adipogenesis, and cell adhesion. C. fructus extract (CFE) exhibits an angiogenesis inhibi</I>tory effect superior to that of the EGCG from green tea leaves. The expression level of angiogenesis and adipogenesis-related signal molecules in the western blotting was reduced by increasing... -
Chronic Administration of Monosodium Glutamate under Chronic Variable Stress Impaired Hypothalamic-Pituitary-Adrenal Axis Function in Rats
HeeJeongSeo, Hyang-DoHam, HyungYongJin, WooHyungLee, HyunSubHwang, Soon-AhPark, YongSungKim, SuckCheiChoi, SeoulLee, KyungJaeOh, ByungSook 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2010, Vol.14 No.4 3 213-221 (9 pages)
plasma corticosterone levels between chronic stress and daily care or acute stress, 2 groups were added at the end of the experiment; the 2 new groups were as follows: naïve mice (n=7) and mice exposed to restraint stress for 2 h just before decapitation (A-Str, n=7). In an open field test performed after the experiment, the CVS+MSG group significant decrease in activity. The increase in relative adrenal weights in the CVS and CVS+MSG group was significantly greater than those in the CON... -
Fenofibrate Reduces Age-related Hypercholesterolemia in Normal Rats on a Standard Diet
YingHan, Mi-HyangDo, MiSunKim, EunhuiSeo, Mi-KyoungPark, DukKyuKim, Hye-JeongLee, Su-YeongSeo 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 5 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2010, Vol.14 No.2 3 77-81 (5 pages)
on a standard diet. Male Sprague-Dawley (SD) rats (n=15) were fed standard chow and water from 10 to 25 weeks of age. During that period, we measured daily food intake, body weight, fasting and random blood glucose levels, plasma total cholesterol (TC), triglycerides (TG), and free fatty acid (FFA) levels. At 20 weeks of age, all rats were randomly divided into two groups: a fenofibrate group (in which rats were gavaged with 300 mg/kg/day of fenofibrate) and a control group (gavaged with water).... -
Increase of NADPH-diaphorase Expression in Hypothalamus of Stat4 Knockout Mice
MeeSookHong, JeongYoonSong, DongHwanYun, Jeong-JeCho, Joo-HoChung 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 5 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2009, Vol.13 No.5 1 337-341 (5 pages)
synthase (Nos1), which is also related to food intake, was investigated in the hypothalamic areas of Stat4 knockout (KO) mice using nicotinamide adenine dinucleotide phosphate-diaphorase (NADPH-d) histochemistry, a marker for neurons expressing Nos1 enzyme. Western blots were also performed to evaluate Nos1 and Fos expression. Wild-type Balb/c (WT group, n=10 male) and Stat4 KO mice (Stat4 KO group, n=8 male) were used. The body weight and daily food intake in the WT group were 22.4±0.3 and 4.4... -
Developmental Disability Animal Model Based on Neonatal Lipopolysaccharide with Altered 5-HT Function
JaeGooKim, MinSooKim, SeoulLee, GunTaeKim, JongDooLee, DongGooKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2007, Vol.11 No.3 6 113-119 (7 pages)
Developmental disability shows life-long behavioral abnormality with no significant physical malformation. This study was undertaken to develop an animal model for developmental disability by using two-factor approach. Lipopolysaccharide (LPS), a bacterial toxin, and NAN-190, a 5-HT1A receptor antagonist, were administered to Sprague-Dawley rats on postnatal day (PND) 5 to induce inflammation and an altered 5-HT system, respectively. Long-term alteration of behavior occurred in the drug-treated... -
Metformin Enhances Leptin Sensitivity in Aged Rats
SaeRomKim, So-YoungPark, JongYeonKim, YongWoonKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2006, Vol.10 No.1 1 1-6 (6 pages)
by measuring food intake, body weight and visceral fat losing effects. Leptin (15μg/D) was administered by intracerobroventricular (i.c.v.) infusion through osmotic minipump for 1 week. Metformin treatment decreased body weight and daily food intake in both adult and aged rats compared with their control rats, however, these effects were more prominent in aged rats than in adult rats. Anorexic and fat losing responses following i.c.v. leptin were attenuated in aged rats compared to adult rats.... -
Insulin Resistance of Skeletal Muscle was Recovered by Leptin Injection in vivo, but not in vitro, in High-fat Diet Fed Rats
Kyung-OhDoh, Jeong-OakPark, Jeong-RyaeJeon, Jong-YeonKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2005, Vol.9 No.2 8 125-130 (6 pages)
We examined the effect of leptin on the insulin resistance in skeletal muscles by measuring the glucose transport. Male Wistar rats were fed with chow or high-fat diets for 30 days. Three days before sacrifice, high-fat fed rats were subcutaneously injected with leptin (1 mg/kg body weight) for 3 days. The glucose transports in the epitrochlearis and soleus muscle were not different among the experimental groups under basal state, however these were decreased significantly in the high fat-diet... -
Effects of Pretreatment of Serotonin Synthesis Inhibitor p-chlorophenylalanine on Lipopolysaccharide-induced Anorexia in Rats
So-youngPark, ByungSuckKim, SeoungSookBack 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2001, Vol.5 No.2 3 133-138 (6 pages)
a day), food intake was decreased by 33% and daily gain in body weight was inhibited compared with controls. Twenty-four hours after last PCPA injection, food intake and gain in body weight returned toward almost normal. Pair-feeding to PCPA (PCPAP) injection revealed that body weight of rats in PCPA group was not different from rats in PCPAP groups. To quantify the effects of LPS on food intake and body weight, we administered varying doses (10, 100, 500μg/kg BW) of LPS to rats. LPS induced a... -
Effects of Acarbose on the Expression of Obese and Neuropeptide Y (NPY) Genes in Mice on High-Carbohydrate Diet
JiyeonKimSunghyunChung 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1999, Vol.3 No.4 8 433-438 (6 pages)
Y (NPY), were investigated in the ICR mice on a high- carbohydrate diet. Acarbose, administered 5 or 50 mg per 100 g diet for four weeks, dose dependently suppressed body weight gain. The body weight gain was reduced along with the amount of daily food intake in 50 mg acarbose-treated group at 7th and 28th day. 5 or 50 mg acarbose treatment administered for four weeks reduced leptin mRNA levels to 62% and 77% of the control group, demonstrating that the amount of leptin mRNA in adipocytes... -
입원 남성 및 여성 알코올리즘 환자의 인구학적, 임상적 및 인격적 특성비교
정원후, 김성부, 장기용, 손진욱, 박철수 대한신경정신의학회 신경정신의학 17 Pages
대한신경정신의학회 신경정신의학 1997, 제 36권 제 4호 10 688-704 (17 pages)
저자들은 1996년 5월 1일부터 1996년 7월 15일까지 부산·경남·대구 소재의 대형정신병원과 종합병원 에 입원해 있는 여성 알코올리즘을 대상으로 하고, 또한 같은 기간에 국립부곡정신병원에 입원한 남성 알코올 리즘을 비교군으로 해서 사회인구학적 특성, 음주양상, 음주와 관련된 문제점, 성격 및 정신병리 등을 비교하 여 남녀 알코올리즘에서의 원인과 임상적 특성에서의 차이점을 알고자해서 본 연구를 하게 되었다. 저자들이 작성한 반구조화된 설문지, MAST(Michigan alcoholism screening test), Zung의 SAS(Self-rating...


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