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Extracellular acidity enhances tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis via DR5 in gastric cancer cells
Ran Hong, Song Iy Han 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 11 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2018, Vol.22 No.5 5 513-523 (11 pages)
The tumor microenvironment greatly influences cancer cell characteristics, and acidic extracellular pH has been implicated as an essential factor in tumor malignancy and the induction of drug resistance. Here, we examined the characteristics of gastric carcinoma (GC) cells under conditions of extracellular acidity and attempted to identify a means of enhancing treatment efficacy. Acidic conditions caused several changes in GC cells adversely affecting chemotherapeutic treatment. Extracellular... -
MDL-12330A potentiates TRAIL-induced apoptosis in gastric cancer cells through CHOP-mediated DR5 upregulation
Sung-ChulLimSongIyHan 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2017, Vol.21 No.4 5 397-405 (9 pages)
MDL-12330A is a widely used adenylyl cyclase (AC) inhibitor that blocks AC/cAMP signaling. In this study, we demonstrated a novel antitumor activity of this drug in gastric carcinoma (GC) cell lines. In these GC cells, MDL-12330A reduced cell viability and induced cell death in a concentration-dependent manner. At a moderate concentration (~20 μM), MDL-12330A mainly induced apoptotic death whereas at concentrations greater than 20 μM, it increased non-apoptotic cell death. The induction of... -
Cocaine-induced Changes in Functional Connectivities between Simultaneously Recorded Single Neurons in the SI Cortex and the VPL Thalamus of Conscious Rats
Shin, Hyung-Cheul, Park, Hyoung-Jin, Oh, Yang-Seok, Chapin, John K. 대한생리학회 대한생리학회지 14 Pages
대한생리학회 대한생리학회지 1993, 제 27권 제 1호 8 79-92 (14 pages)
The present study was carried out to determine the effects of cocaine (0.25, 1.0, 10.0 mg/kg, i.p.) on the interactions between spontaneously active neurons within ensembles of simultaneously recorded neurons in the primary somatosensory cortex (Sl, n= 20) and the ventroposterolateral (VPL, n= 16) thalamic nucleus of awake rats. Spike triggered cross correlation histograms were constructed between pairs of simultaneously recorded neurons. Among 101 neuronal pairs analyzed, 22.7% showed... -
Screening of Endophytic Antagonistic Bacterium from Phellodendron amurense and Their Biocontrol Effects against Canker Rot
Shujiang Li, Xinmei Fang, Hanlian Zhang, Yanling Zeng, Tianhui Zhu 한국식물병리학회 The Plant Pathology Journal 9 Pages
한국식물병리학회 The Plant Pathology Journal 2019, 35권 3호 5 234-242 (9 pages)
Thirty-four strains of bacteria were isolated from Phellodendron amurense. Using Nectria haematococca as an indicator strain, the best strain, B18, was obtained by the growth rate method. The morphological, physiological and biochemical characteristics of strain B18 and its 16S DNA gene sequence were identified, and the biocontrol effect of strain B18 was assessed in pot and field tests, as well as in a field-control test. Drilling methods were used to determine the antibacterial activity of... -
Biological Control of Bacterial Fruit Blotch of Watermelon Pathogen (Acidovorax citrulli) with Rhizosphere Associated Bacteria
한국식물병리학회 The Plant Pathology Journal 14 Pages
한국식물병리학회 The Plant Pathology Journal 2017, 33권 2호 9 170-183 (14 pages)
Bacterial fruit blotch (BFB), which is caused by Acidovorax citrulli, is a serious threat to watermelon growers around the world. The present study was conducted to screen effective rhizobacterial isolates against 35 different A. citrulli isolates and determine their efficacy on BFB and growth parameters of watermelon. Two rhizobacterial isolates viz. Paenibacillus polymyxa (SN-22), Sinomonas atrocyanea (NSB-27) showed high inhibitory activity in the preliminary screening and were further... -
터널 화재 시 피난통로 확보를 위한 안전성 연구
임경범, 김종윤 한국웰니스학회 한국웰니스학회지 8 Pages
한국웰니스학회 한국웰니스학회지 2009, 제 4권 2호 11 109-116 (8 pages)
터널은 일반도로와는 달리 반 밀폐 공간 및 대 피방법의 단일성이라는 점에서 일반도로가 갖는 위험요소보다 더 많은 위험요소를 내포한다(박시헌, 오혁희, 오상직, 2003; 한국건설기술연구원, 2005). 특히 터널화재 시 발생되는 각종 화재 발화가스로 인하여 가시거리의 미확보, 유독성가스의 확산 및 급격한 온도상승, 산소농도의 감소를 초래함으로서 화재현장까지 화재진화를 위한 소방대의 접근을 어렵게 함으로 인한 심리적인 불안감과 공포감을 야기 시키고 있다. 이러한 터널 화재는 승객의 인 명피해는 물론 터널구조물 및... -
Graphitization of PAN-based carbon fibers by CO₂ laser irradiation
Liangbo Yao, Weimin Yang, Sanyang Li, Yang Sha, Jing Tan, Ying An, Haoyi Li 한국탄소학회 Carbon Letters 6 Pages
한국탄소학회 Carbon Letters 2017, Vol.24 13 97-102 (6 pages)
Graphite fibers are materials with a high specific modulus that have attracted much interest in the aerospace industry, but their high manufacturing cost and low yield are still problems that prevent their wide applications in practice. This paper presents a laser-based process for graphitization of carbon fiber (CF) and explores the effect of laser radiation on the microstructure of CF. The obtained Raman spectra indicate that the outer surface of CF evolves from turbostratic structures into a... -
유한차분법과 유한체적법을 이용한 1차원과 2차원 개수로 흐름해석
김만식, 이진희, 정찬, 박노혁 한국습지학회 한국습지학회지 13 Pages
한국습지학회 한국습지학회지 2008, Vol.10 No.2 5 67-79 (13 pages)
하천에서의 부정류 해석을 위해서 1차원 유한차분법(FDM)인 Abbott-Ionescu scheme과 2차원 유한체적법(FVM)인 근사의 Riemann solver(Osher scheme)에 대하여 살펴보았다. 두 모형은 직선 하도, 약간 굽어진 사행하도 및 사행하도에서의 흐름 문제들에 적용되었으며 결과의 비교는 균일한 직사각형 수로에 대하여 이루어졌다. 하천의 복잡한 형상의 표현하기 위해서는 이를 고려할 수 있는 유한체적법을 이용하였다. 유한차분법과 유한체적법 결과는 수위 및 유량 수문곡선에 대하여 매우 만족스러운 것으로 나타났다. 균일한 직선하도에...


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