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111.

Inhibitory Effects of Verapamil and TMB-8 on Tonic Contraction Are Accompanied by Inhibition of Phospholipase C Activity in Intact Gastric Smooth Muscle Cells

Sim, Sang-Soo, Yoon, Shin-Hee, Hahn, Sang-June, Rhie, Duck-Joo, Jo, Yang-Hyeok, Kim, Myung-Suk 대한생리학회 대한생리학회지 10 Pages

대한생리학회 대한생리학회지 1995, 제 29권 제 1호 3 29-38 (10 pages)

Sim, Sang-Soo, Yoon, Shin-Hee, Hahn, Sang-June, Rhie, Duck-Joo, Jo, Yang-Hyeok, Kim, Myung-Suk 저
...
- 3,000원
Gastric smooth muscle of guinea pigs was used to investigate whether the inhibitory effect of calcium antagonists on tonic contraction was accompanied by inhibition of phospholipase C activity. Tonic contraction and [3H] inositol phosphate (IP) formation in response to acetylcholine were measured after pretreatment with verapamil, nifedipine, 8-(N,N-diethylamino)octyl 3,4,5-trimethoxy-benzoate (TMB-8) or EGTA. Verapamil (10 μM), TMB-8 (10 μM) or EGTA (2 mM) significantly inhibited...
112.

Effects of cGMP on the Contractility and Ca Movement in the Aorta of Normotensive Wistar-Kyoto Rats and Spontaneously Hypertensive Rats

Park, Hae-Kun, Jeon, Byeong-Hwa, Kim, Se-Hoon, Kim, Hoe-Suk, Chang, Seok-Jong 대한생리학회 대한생리학회지 10 Pages

대한생리학회 대한생리학회지 1994, 제 28권 제 2호 8 181-190 (10 pages)

Park, Hae-Kun, Jeon, Byeong-Hwa, Kim, Se-Hoon, Kim, Hoe-Suk, Chang, Seok-Jong 저
...
- 3,000원
Tyrode s solution were suppressed by the pretreatment with 8-Br-cGMP (10-4 M) in either strain. However, the amplitudes of suppression induced by 8-Br-cGMP were greater in SHR than that in WKY. Basal 45Ca uptake and 40mM K+-stimulated 45Ca uptake were not suppressed by pretreatment with 8-Br-cGMP (10-4 M) in single aortic smooth muscle cells of both SHR and WKY. From the above results, it is suggested that cGMP decreases Ca sensitivity in vascular smooth muscle cells and that the impaired...
113.

Effect of pH on the Vascular Tone and 45Ca Uptake in the Aorta of Spontaneously Hypertensive Rats

Chang, Seok-Jong, Jeon, Byeong-Hwa, Kim, Se-Hoon, Kim, Hoe-Suk, Park, Hae-Kun 대한생리학회 대한생리학회지 12 Pages

대한생리학회 대한생리학회지 1994, 제 28권 제 2호 7 169-180 (12 pages)

Chang, Seok-Jong, Jeon, Byeong-Hwa, Kim, Se-Hoon, Kim, Hoe-Suk, Park, Hae-Kun 저
...
- 4,100원
The effect of extracellular and intracellular pH on vascular tone and 45Ca uptake were investigated in aortic strips and dispersed single aortic smooth muscle cells of spontaneously hypertensive rats (SHR) and aged-matched Wistar-Kyoto rats (WKY). The contraction produced by a change of extracellular pH (pHo) in the range of 6.5 ~ 8.3 was estimated by comparison with the level of vascular tone at pH 7.4. Contraction was induced below pHo 6.5 in WKY, pHo 7.1 in SHR, and over pHo 8.0 on both...
114.

Calcium-activated Ionic Currents in Smooth Muscle Cells from Rabbit Superior Mesenteric Artery

Lee, Moo-Yeol, Bang, Hyo-Weon, Uhm, Dae-Yong, Rhee, Sang-Don 대한생리학회 대한생리학회지 8 Pages

대한생리학회 대한생리학회지 1994, 제 28권 제 2호 5 151-158 (8 pages)

Lee, Moo-Yeol, Bang, Hyo-Weon, Uhm, Dae-Yong, Rhee, Sang-Don 저
...
- 3,000원
Intracellular free Ca2+ contributes to regulation of various events occurring in vascular smooth muscle cells. One of these events is modulating the membrane iou currents. Single smooth muscle cells were isolated from rabbit mesenteric artery. Three kinds of Ca2+-activated current were studied with the patch clamp method. Ca2+-activated K+ current with a large oscillation was recorded in the depolarized potential range. The single channel conductance of this current was about 250 pS. It was...
115.

Ca2+-activated Cl- Current in Gastric Antral Myocytes

Lee, Moo-Yeol, Bang, Hyo-Weon, Uhm, Dae-Yong, Rhee, Sang-Don 대한생리학회 대한생리학회지 8 Pages

대한생리학회 대한생리학회지 1994, 제 28권 제 2호 4 143-150 (8 pages)

Lee, Moo-Yeol, Bang, Hyo-Weon, Uhm, Dae-Yong, Rhee, Sang-Don 저
...
- 3,000원
The whole-cell mode of the patch clamp technique was used to study Ca2+-activated Cl- current (IClCa) in gastric antral myocytes. Extracellular application of caffeine evoked Ca2+-activated current. In order to isolate the chloride current from background current, all known systems were blocked with specific blockers. The current-voltage relationship of caffeine-induced current showed outward rectification and it reversed at around ECl-. The shift of reversal potential upon the alteration of...
116.

The Excitatory Mechanism of Substance P in the Antral Circular Muscle of Guinea Pig Stomach

Jun, Jae-Yeoul, Kim, Sung-Joon, Choi, Youn-Baik, Kim, Ki-Whan 대한생리학회 대한생리학회지 10 Pages

대한생리학회 대한생리학회지 1994, 제 28권 제 1호 5 51-60 (10 pages)

Jun, Jae-Yeoul, Kim, Sung-Joon, Choi, Youn-Baik, Kim, Ki-Whan 저
...
- 3,000원
50mV in 10mV steps and this effect was blocked by the addition of an antagonist. Also Substance P increased transient and spontaneous oscillatory K+ outward currents. The enhanced outward currents were abolished by apamin in dispersed single cells. These results suggest that the depolarization of membrane potential by Substance P activates voltage-dependent Ca2+ channels, which represents an excitatory response in the antral circular muscle and led to an increase in Ca2+ activated K+ currents
117.

Effects of Lemakalim, a Potassium Channel Opener, on the Contractility and Electrical Activity of the Antral Circular Muscle in Guinea-Pig Stomach

Kim, Sung-Joon, Jun, Jae-Yeoul, Choi, Youn-Baik, Kim, Ki-Whan, Kim, Woo-Gyeum 대한생리학회 대한생리학회지 14 Pages

대한생리학회 대한생리학회지 1994, 제 28권 제 1호 4 37-50 (14 pages)

Kim, Sung-Joon, Jun, Jae-Yeoul, Choi, Youn-Baik, Kim, Ki-Whan, Kim, Woo-Gyeum 저
...
- 4,300원
Synthetic potassium channel openers (KCOs) are agents capable of opening K-channels in excitable cells. These agents are known to have their maximal potency in the smooth muscle tissue, especially in the vascular smooth muscle. Much attention has been focused on the type of K-channel that is responsible for mediating the effects of KCOs. As the KCO-induced changes are antagonized by glibenclamide, an KATP (ATP-sensitive K-channel) blocker in the pancreatic β-cell, KATP was suggested to be the...
118.

Ca-dependent Alteration in Basal Tone, Basal 45Ca Uptake and 3H-nitrendipine Binding in the Aorta of Spontaneously Hypertensive Rats

Chang, Seok-Jong, Jeon, Byeong-Hwa, Kim, Hoe-Suk 대한생리학회 대한생리학회지 10 Pages

대한생리학회 대한생리학회지 1994, 제 28권 제 1호 3 27-36 (10 pages)

Chang, Seok-Jong, Jeon, Byeong-Hwa, Kim, Hoe-Suk 저
...
- 3,000원
muscles in the spontaneously hypertensive rats (SHR) and Wistar-Kyoto (WKY) rats. While the basal tone of the aortic strips in WKY rats was not affected by alteration of Ca concentration, that in SHR was decreased by the removal of Ca from the bath solution and was recovered by the restoration of Ca to normal levels. This contraction increased in a Ca concentration-dependent manner and reached a maximum at 2 mM Ca. The basal tone of aorta in SHR was suppressed by verapamil (10-6M). The basal to...
119.

Effect of Dopamine on the Ca2+-dependent K+ currents in Isolated Single Gastric Myocytes of the Guinea-pig

Rhee, Poong-Lyul, Lee, Sang-Jin, Kim, Sung-Joon, So, In-Suk, Hwang, Sang-Ik, Kim, Ki-Whan 대한생리학회 대한생리학회지 12 Pages

대한생리학회 대한생리학회지 1993, 제 27권 제 2호 3 139-150 (12 pages)

Rhee, Poong-Lyul, Lee, Sang-Jin, Kim, Sung-Joon, So, In-Suk, Hwang, Sang-Ik, Kim, Ki-Whan 저
...
- 4,100원
of dopamine on the gastric smooth muscle, the effects of dopamine on voltage-dependent Ca2+ currents and Ca2+ -dependent K+ currents were observed in enzymatically dispersed guinea-pig gastric myocytes using the whole-cell voltage-clamp technique. Experiments were also done using isometric tension recording and conventional intracellular microelectrode techniques. 1) The effect of dopamine on the spontaneous contraction of antral circular muscle strips of the guinea-pig was excitatory in a...
120.

Effects of Noradrenaline on the Spontaneous Contraction and Ionic Current in the Antral Circular Muscle of Guinea-pig Stomach

Jun, Jae-Yeoul, Lee, Sang-Jin, Kim, Sung-Joon, Suh, Jae-Yul, So, In-Suk, Hwang, Sang-Ik, Kim, Ki-Whan 대한생리학회 대한생리학회지 8 Pages

대한생리학회 대한생리학회지 1993, 제 27권 제 2호 1 115-122 (8 pages)

Jun, Jae-Yeoul, Lee, Sang-Jin, Kim, Sung-Joon, Suh, Jae-Yul, So, In-Suk, Hwang, Sang-Ik, Kim, Ki-Whan 저
...
- 3,000원
There is evidence that noradrenaline enhances spontaneous contractions dose-dependently in guinea-pig antral circular muscle. To investigate the mechanism of this excitatory action, slow waves and membrane currents were recorded using conventional microelectrode techniques in muscle strips and the whole cell patch clamp technique in isolated gastric myocytes. On recording slow waves, noradrenaline (10-5 M) induced the hyperpolarization of the membrane potential, although the shape of the slow...

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