학지사 뉴논문

총 771건 검색

본문검색 결과만 보기

정확도순

최신순

등재순

발행기간

전체
최근 1년
최근 3년
직접입력

적용하기

본문검색

포함

제외

10개씩

121.

Are Spinal GABAergic Elements Related to the Manifestation of Neuropathic Pain in Rat?

JaeheeLee, SeungKeunBack, EunJeongLim, GyuChongCho, MyungAhKim, HeeJinKim, MinHeeLee, HeungSikNa 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 11 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2010, Vol.14 No.2 1 59-69 (11 pages)

JaeheeLee, SeungKeunBack, EunJeongLim, GyuChongCho, MyungAhKim, HeeJinKim, MinHeeLee, HeungSikNa 저
...
- 4,000원
in nerve-injured animals. However, any quantitative changes in spinal GABAergic elements were not observed in both the allodynic and non-allodynic groups. These results suggest that although the impairment in spinal GABAergic inhibition may play a role in mediation of neuropathic pain, it is not accomplished by the quantitative change in spinal elements for GABAergic inhibition and therefore these elements are not related to the generation of neuropathic pain following peripheral nerve injury.
122.

Inhibition of eNOS/sGC/PKG Pathway Decreases Akt Phosphorylation Induced by Kainic Acid in Mouse Hippocampus

SangHyunLee, JongSeonByun, PilJaeKong, HeeJaeLee, DukKyungKim, HaeSungKim, Jong-HeeSohn, JaeJunLee, , SoYoungLim, WanjooChun, SungSooKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2010, Vol.14 No.1 6 37-43 (7 pages)

SangHyunLee, JongSeonByun, PilJaeKong, HeeJaeLee, DukKyungKim, HaeSungKim, Jong-HeeSohn, JaeJunLee, , SoYoungLim, WanjooChun, SungSooKim 저
...
- 3,000원
The serine/threonine kinase Akt has been shown to play a role of multiple cellular signaling pathways and act as a transducer of many functions initiated by growth factor receptors that activate phosphatidylinositol 3-kinase (PI3K). It has been reported that phosphorylated Akt activates eNOS resulting in the production of NO and that NO stimulates soluble guanylate cyclase (sGC), which results in accumulation of cGMP and subsequent activation of the protein kinase G (PKG). It has been also...
123.

Mechanisms of Selective Antimicrobial Activity of Gaegurin 4

HeejeongKim, ByeongJaeLee, MunHanLee, SeongGeunHong, PanDongRyu 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 10 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2009, Vol.13 No.1 7 39-48 (10 pages)

HeejeongKim, ByeongJaeLee, MunHanLee, SeongGeunHong, PanDongRyu 저
...
- 3,000원
Gaegurin 4 (GGN4), an antimicrobial peptide isolated from a Korean frog, is five times more potent against Gram-positive than Gram-negative bacteria, but has little hemolytic activity. To understand the mechanism of such cell selectivity, we examined GGN4-induced K＋ efflux from target cells, and membrane conductances in planar lipid bilayers. The K＋ efflux from Gram-positive M. luteus (2.5</SUP>Ռg/ml) was faster and larger than that from Gram-negative E. coli (75Ռg/ml), while...
124.

Oxidized Low-density Lipoprotein- and Lysophosphatidylcholine-induced Ca2＋ Mobilization in Human Endothelial Cells

MoonYoungKim, GuoHuaLiang, JiAeeKim, SooSeungChoi, ShinkuChoi, SukHyoSuh 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2009, Vol.13 No.1 5 27-32 (6 pages)

MoonYoungKim, GuoHuaLiang, JiAeeKim, SooSeungChoi, ShinkuChoi, SukHyoSuh 저
...
- 3,000원
The effects of oxidized low-density lipoprotein (OxLDL) and its major lipid constituent lysophosphatidylcholine (LPC) on Ca2＋ entry were investigated in cultured human umbilical endothelial cells (HUVECs) using fura-2 fluorescence and patch-clamp methods. OxLDL or LPC increased intracellular Ca2＋ concentration ([Ca2＋]i), and the increase of [Ca2＋]i by OxLDL or by LPC was inhibited by La3＋ or heparin. LPC failed to increase [Ca2＋]i in the presence of an antioxidant tempol. In addition,...
125.

Modeling of Arrhythmogenic Automaticity Induced by Stretch in Rat Atrial Myocytes

JaeBoumYoum, ChaeHunLeem, YinHuaZhang, NariKim, JinHan, YungE.Earm 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2008, Vol.12 No.5 8 267-274 (8 pages)

JaeBoumYoum, ChaeHunLeem, YinHuaZhang, NariKim, JinHan, YungE.Earm 저
...
- 3,000원
The early phase was driven by increased background conductance of voltage-gated Na＋ channel, whereas the later phase was driven by the reverse-mode operation of Na＋/Ca2＋ exchange current secondary to the accumulation of Na＋ and Ca2＋ through SACs. These results of simulation successfully demonstrate how the SACs can induce automaticity in a single atrial myocyte which may act as a focus to initiate and maintain atrial fibrillation in concert with other arrhythmogenic changes in the heart.
126.

PKC-Independent Stimulation of Cardiac Na+/Ca2+ Exchanger by Staurosporine

TongMookKang 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2008, Vol.12 No.5 7 259-266 (8 pages)

TongMookKang 저
...
- 3,000원
[Ca2+]i transients by reverse mode of cardiac Na+/Ca2+ exchanger (NCX1) were recorded in fura-2 loaded BHK cells with stable expression of NCX1. Repeated stimulation of reverse NCX1 produced a long-lasting decrease of Ca2+ transients ('rundown'). Rundown of NCX1 was independent of membrane PIP2 depletion. Although the activation of protein kinase C (PKC) was observed during the Ca2+ transients, neither a selective PKC inhibitor (calphostin C) nor a PKC activator (PMA) changed the degrees of...
127.

Expression of Ca2+-activated K+ Channels and Their Role in Proliferation of Rat Cardiac Fibroblasts

SeyongChoi, WooseokLee, JihyunYun, JeongseokSeo, InjaLim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2008, Vol.12 No.2 3 51-58 (8 pages)

SeyongChoi, WooseokLee, JihyunYun, JeongseokSeo, InjaLim 저
...
- 3,000원
members of KCa channels, including large conductance KCa (BK-Ձ1- and -Ղ1∼4 subunits), intermediate conductance KCa (IK), and small conductance KCa (SK1∼4 subunits) channels. Thirdly, we recorded BK, IK, and SK channels by whole cell mode patch clamp technique using their specific blockers. Finally, we performed cell proliferation assay to evaluate the effects of the channels on cell proliferation, and found that the inhibition of IK channel increased the cell proliferation. These...
128.

Ca2+-dependent Long-term Inactivation of Cardiac Na+/Ca2+ Exchanger

Jee-EunLee, TongMookKang 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2007, Vol.11 No.5 4 183-188 (6 pages)

Jee-EunLee, TongMookKang 저
...
- 3,000원
Using BHK cells with stable expression of cardiac Na+/Ca2+ exchanger (BHK-NCX1), reverse mode (i.e. Ca2+ influx mode) of NCX1 current was recorded by whole-cell patch clamp. Repeated stimulation of reverse NCX1 produced a cytosolic Ca2+-dependent long-term inactivation of the exchanger activity. The degrees of inactivation correlated with NCX1 densities of the cells and were attenuated by reduced Ca2+ influx via the reverse exchanger. The inactivation of NCX1 was attenuated by (i) inhibition of...
129.

Tetanus-induced LTD of Developing MNTB-LSO Synapses in Rat is Dependent on Postsynaptic Ca2+

SeungCheolAhn 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2007, Vol.11 No.3 1 79-84 (6 pages)

SeungCheolAhn 저
...
- 3,000원
2 min) in the current clamp mode induced a robust LTD of isolated D, L-APV-sensitive postsynaptic currents (PSCs) for more than 30 min (n=6, 2.4⁑0.4% of the control), while isolated CNQX-sensitive PSCs were not suppressed (n=6, 95.3⁑1.6%). Tetanus also elicited similar LTD in the isolated GABAergic/glycinergic PSCs (n=5, 3.6⁑0.5%) and mixed PSCs (GABAergic/glycinergic/glutamatergic) (n=4, 2.2⁑0.7%). However, such a strong LTD was not observed in the mixed PSCs when 10 mM...
130.

Effects of pH, Buffer System and Lactate on the Simulated Ischemia-reperfusion Injury of H9c2 Cardiac Myocytes

JunWheeLee, HyeKyungLee, HaeWonKim, Young-HoonKim, 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 11 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2007, Vol.11 No.2 2 45-55 (11 pages)

JunWheeLee, HyeKyungLee, HaeWonKim, Young-HoonKim, 저
...
- 4,000원
We elucidated the effects of various components of ischemic medium on the outcome of simulated ischemia-reperfusion injury. Hypoxia for up to 12 hours induced neither apoptotic bodies nor LDH release. However, reoxygenation after 6 or 12 hours of hypoxia resulted in a marked LDH release along with morphological changes compatible with oncotic cell death. H9c2 cells were then subjected to 6 hours of simulated ischemia by exposing them to modified hypoxic glucose-free Krebs-Henseleit buffer....

한주간 이슈검색어