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121.

Alleviation of ascorbic acid-induced gastric high acidity by calcium ascorbate in vitro and in vivo

Joon-KyungLee, Sang-HyukJung, Sang-EunLee, Joo-HuiHan, EunjiJo, Hyun-SooPark, Kyung-SunHeo, DeasunKim, Jeong-SookPark, Chang-SeonMyung 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2018, Vol.22 No.1 4 35-42 (8 pages)

Joon-KyungLee, Sang-HyukJung, Sang-EunLee, Joo-HuiHan, EunjiJo, Hyun-SooPark, Kyung-SunHeo, DeasunKim, Jeong-SookPark, Chang-SeonMyung 저
...
- 3,000원
Ascorbic acid is one of the most well-known nutritional supplement and antioxidant found in fruits and vegetables. Calcium ascorbate has been developed to mitigate the gastric irritation caused by the acidity of ascorbic acid. The aim of this study was to compare calcium ascorbate and ascorbic acid, focusing on their antioxidant activity and effects on gastric juice pH, total acid output, and pepsin secretion in an in vivo rat model, as well as pharmacokinetic parameters. Calcium ascorbate and...
122.

The bifunctional effect of propofol on thromboxane agonist (U46619)-induced vasoconstriction in isolated human pulmonary artery

NingHao, ZhaojunWang, SujuanKuang, GuangyanZhang, ChunyuDeng, JueMa, JianxiuCui 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2017, Vol.21 No.6 3 591-598 (8 pages)

NingHao, ZhaojunWang, SujuanKuang, GuangyanZhang, ChunyuDeng, JueMa, JianxiuCui 저
...
- 3,000원
Propofol is known to cause vasorelaxation of several systemic vascular beds. However, its effect on the pulmonary vasculature remains controversial. In the present study, we investigated the effects of propofol on human pulmonary arteries obtained from patients who had undergone surgery. Arterial rings were mounted in a Multi-Myograph system for measurement of isometric forces. U46619 was used to induce sustained contraction of the intrapulmonary arteries, and propofol was then applied (in...
123.

Electrophysiological characteristics of R47W and A298T mutations in CLC-1 of myotonia congenita patients and evaluation of clinical features

HyungJinChin, ChanHyeongKim, KotdajiHa, JinHongShin, Dae-SeongKim, InsukSo 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2017, Vol.21 No.4 10 439-447 (9 pages)

HyungJinChin, ChanHyeongKim, KotdajiHa, JinHongShin, Dae-SeongKim, InsukSo 저
...
- 3,000원
Myotonia congenita (MC) is a genetic disease that displays impaired relaxation of skeletal muscle and muscle hypertrophy. This disease is mainly caused by mutations of CLCN1 that encodes human skeletal muscle chloride channel (CLC-1). CLC-1 is a voltage gated chloride channel that activates upon depolarizing potentials and play a major role in stabilization of resting membrane potentials in skeletal muscle. In this study, we report 4 unrelated Korean patients diagnosed with myotonia congenita...
124.

Activation of transient receptor potential vanilloid 3 by the methanolic extract of Schisandra chinensis fruit and its chemical constituent γ-schisandrin

YuranNam, HyunJongKim, Young-MiKim, Young-WonChin, YungKyuKim, HyoSangBae, JooHyunNam, WooKyungKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2017, Vol.21 No.3 5 309-316 (8 pages)

YuranNam, HyunJongKim, Young-MiKim, Young-WonChin, YungKyuKim, HyoSangBae, JooHyunNam, WooKyungKim 저
...
- 3,000원
Transient receptor potential vanilloid 3 (TRPV3) is a non-selective cation channel with modest permeability to calcium ions. It is involved in intracellular calcium signaling and is therefore important in processes such as thermal sensation, skin barrier formation, and wound healing. TRPV3 was initially proposed as a warm temperature sensor. It is activated by synthetic small-molecule chemicals and plantderived natural compounds such as camphor and eugenol. Schisandra chinensis (Turcz.) Baill...
125.

Peroxisome proliferator-activated receptor γ is essential for secretion of ANP induced by prostaglandin D2 in the beating rat atrium

YingZhang, XiangLi, Li-PingLiu, LanHong, XiaLiu, BoZhang, Cheng-ZheWu, XunCui 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2017, Vol.21 No.3 3 293-300 (8 pages)

YingZhang, XiangLi, Li-PingLiu, LanHong, XiaLiu, BoZhang, Cheng-ZheWu, XunCui 저
...
- 3,000원
Prostaglandin D2 (PGD2) may act against myocardial ischemia–reperfusion (I/R) injury and play an anti-inflammatory role in the heart. Although the effect of PGD2 in regulation of ANP secretion of the atrium was reported, the mechanisms involved are not clearly identified. The aim of the present study was to investigate whether PGD2 can regulate ANP secretion in the isolated perfused beating rat atrium, and its underlying mechanisms. PGD2 (0.1 to 10 μM) significantly increased atrial ANP...
126.

Pimecrolimus increases the melanogenesis and migration of melanocytes in vitro

PingXu, JieChen, ChengTan, Ren-ShengLai, Zhong-ShengMin 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2017, Vol.21 No.3 2 287-292 (6 pages)

PingXu, JieChen, ChengTan, Ren-ShengLai, Zhong-ShengMin 저
...
- 3,000원
Vitiligo is an intriguing depigmentary disorder and is notoriously difficult to be treated. The ultimate goal of vitiligo treatment is to replenish the lost melanocytes by immigration from hair follicle and to restore the normal function of melanogenesis by residual melanocytes. There are two types of topical calcineurin inhibitors called tacrolimus and pimecrolimus, and are recommended as the first-line treatments in vitiligo. Although pimecrolimus is efficacious for the repigmentation of...
127.

Chronic Ca2+ influx through voltage-dependent Ca2+ channels enhance delayed rectifier K+ currents via activating Src family tyrosine kinase in rat hippocampal neurons

Yoon-SilYang, Sang-ChanJeon, Dong-KwanKim, Su-YongEun, Sung-CherlJung 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2017, Vol.21 No.2 14 259-265 (7 pages)

Yoon-SilYang, Sang-ChanJeon, Dong-KwanKim, Su-YongEun, Sung-CherlJung 저
...
- 3,000원
Excessive influx and the subsequent rapid cytosolic elevation of Ca2+ in neurons is the major cause to induce hyperexcitability and irreversible cell damage although it is an essential ion for cellular signalings. Therefore, most neurons exhibit several cellular mechanisms to homeostatically regulate cytosolic Ca2+ level in normal as well as pathological conditions. Delayed rectifier K+ channels (IDR channels) play a role to suppress membrane excitability by inducing K+ outflow in various...
128.

Intracellular calcium-dependent regulation of the sperm-specific calcium-activated potassium channel, hSlo3, by the BKCa activator LDD175

TharakaDarshanaWijerathne, JihyunKim, DongkiYang, KyuPilLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2017, Vol.21 No.2 12 241-249 (9 pages)

TharakaDarshanaWijerathne, JihyunKim, DongkiYang, KyuPilLee 저
...
- 3,000원
Plasma membrane hyperpolarization associated with activation of Ca2+-activated K+ channels plays an important role in sperm capacitation during fertilization. Although Slo3 (slowpoke homologue 3), together with the auxiliary γ2- subunit, LRRC52 (leucine-rich-repeat–containing 52), is known to mediate the pHsensitive, sperm-specific K+ current KSper in mice, the molecular identity of this channel in human sperm remains controversial. In this study, we tested the classical BKCa activators,...
129.

Hydrogen peroxide attenuates refilling of intracellular calcium store in mouse pancreatic acinar cells

MiNaYoon, DongKwanKim, SeHoonKim, HyungSeoPark 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2017, Vol.21 No.2 11 233-239 (7 pages)

MiNaYoon, DongKwanKim, SeHoonKim, HyungSeoPark 저
...
- 3,000원
Intracellular calcium (Ca2+) oscillation is an initial event in digestive enzyme secretion of pancreatic acinar cells. Reactive oxygen species are known to be associated with a variety of oxidative stress-induced cellular disorders including pancreatitis. In this study, we investigated the effect of hydrogen peroxide (H2O2) on intracellular Ca2+ accumulation in mouse pancreatic acinar cells. Perfusion of H2O2 at 300 μM resulted in additional elevation of intracellular Ca2+ levels and...
130.

Lamotrigine, an antiepileptic drug, inhibits 5-HT3 receptor currents in NCB-20 neuroblastoma cells

KiJungKim, SeungHyunJeun, Ki-WugSung 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2017, Vol.21 No.2 4 169-177 (9 pages)

KiJungKim, SeungHyunJeun, Ki-WugSung 저
...
- 3,000원
Lamotrigine is an antiepileptic drug widely used to treat epileptic seizures. Using whole-cell voltage clamp recordings in combination with a fast drug application approach, we investigated the effects of lamotrigine on 5-hydroxytryptamine (5-HT)3 receptors in NCB-20 neuroblastoma cells. Coapplication of lamotrigine (1~300 μM) resulted in a concentration-dependent reduction in peak amplitude of currents induced by 3 μM of 5-HT for an IC50 value of 28.2±3.6 μM with a Hill coefficient of...

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