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131.

Participation of COX-1 and COX-2 in the contractile effect of phenylephrine in prepubescent and old rats

GustavoGuevara-Balcazar, IsraelRamirez-Sanchez, ElviaMera-Jimenez, IvanRubio-Gayosso, MariaEugeniaAguilar-Najera, MariaC.Castillo-Her 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2017, Vol.21 No.4 6 407-413 (7 pages)

GustavoGuevara-Balcazar, IsraelRamirez-Sanchez, ElviaMera-Jimenez, IvanRubio-Gayosso, MariaEugeniaAguilar-Najera, MariaC.Castillo-Her 저
...
- 3,000원
Vascular reactivity can be influenced by the vascular region, animal age, and pathologies present. Prostaglandins (produced by COX-1 and COX-2) play an important role in the contractile response to phenylephrine in the abdominal aorta of young rats. Although these COXs are found in many tissues, their distribution and role in vascular reactivity are not clear. At a vascular level, they take part in the homeostasis functions involved in many physiological and pathologic processes (e.g., arterial...
132.

MDL-12330A potentiates TRAIL-induced apoptosis in gastric cancer cells through CHOP-mediated DR5 upregulation

Sung-ChulLimSongIyHan 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2017, Vol.21 No.4 5 397-405 (9 pages)

Sung-ChulLimSongIyHan 저
...
- 3,000원
MDL-12330A is a widely used adenylyl cyclase (AC) inhibitor that blocks AC/cAMP signaling. In this study, we demonstrated a novel antitumor activity of this drug in gastric carcinoma (GC) cell lines. In these GC cells, MDL-12330A reduced cell viability and induced cell death in a concentration-dependent manner. At a moderate concentration (~20 μM), MDL-12330A mainly induced apoptotic death whereas at concentrations greater than 20 μM, it increased non-apoptotic cell death. The induction of...
133.

Reactive oxygen species increase neuronal excitability via activation of nonspecific cation channel in rat medullary dorsal horn neurons

HaeInLee, ByungRimPark, SangWooChun 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2017, Vol.21 No.4 2 371-376 (6 pages)

HaeInLee, ByungRimPark, SangWooChun 저
...
- 3,000원
The caudal subnucleus of the spinal trigeminal nucleus (medullary dorsal horn; MDH) receives direct inputs from small diameter primary afferent fibers that predominantly transmit nociceptive information in the orofacial region. Recent studies indicate that reactive oxygen species (ROS) is involved in persistent pain, primarily through spinal mechanisms. In this study, we aimed to investigate the role of xanthine/xanthine oxidase (X/XO) system, a known generator of superoxide anion (O2·-), on...
134.

Effects of tianeptine on symptoms of fibromyalgia via BDNF signaling in a fibromyalgia animal model

HwayoungLee, JiyunIm, HansolWon, WooyoungNam, YoungOckKim, SangWonLee, SanghyunLee, Ik-HyunCho, Hyung-KiKim, Jun-TackKwon, Hak-JaeKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 10 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2017, Vol.21 No.4 1 361-370 (10 pages)

HwayoungLee, JiyunIm, HansolWon, WooyoungNam, YoungOckKim, SangWonLee, SanghyunLee, Ik-HyunCho, Hyung-KiKim, Jun-TackKwon, Hak-JaeKim 저
...
- 3,000원
chronic stress and reverse decreases in hippocampal volume. To assess the possible effect of tianeptine on FM symptoms, we constructed a FM animal model induced by restraint stress with intermittent cold stress. All mice underwent nociceptive assays using electronic von Frey anesthesiometer and Hargreaves equipment. To assess the relationship between tianeptine and expression levels of brain-derived neurotrophic factor (BDNF), cAMP response element-binding protein (CREB), and phosphorylated cAMP...
135.

Quercetin induces apoptosis and cell cycle arrest in triple-negative breast cancer cells through modulation of Foxo3a activity

LichThiNguyen, Yeon-HeeLee, AshishRanjanSharma, Jong-BongPark, SupriyaJagga, GarimaSharma, Sang-SooLee, Ju-SukNam 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2017, Vol.21 No.2 8 205-213 (9 pages)

LichThiNguyen, Yeon-HeeLee, AshishRanjanSharma, Jong-BongPark, SupriyaJagga, GarimaSharma, Sang-SooLee, Ju-SukNam 저
...
- 3,000원
Quercetin, a plant-derived flavonoid found in fruits, vegetables and tea, has been known to possess bioactive properties such as anti-oxidant, anti-inflammatory and anti-cancer. In this study, anti-cancer effect of quercetin and its underlying mechanisms in triple-negative breast cancer cells was investigated. MTT assay showed that quercetin reduced breast cancer cell viability in a time and dose dependent manner. For this, quercetin not only increased cell apoptosis but also inhibited cell...
136.

Activation of autophagy at cerebral cortex and apoptosis at brainstem are differential responses to 835 MHz RF-EMF exposure

JuHwanKim, Da-HyeonYu, HakRimKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 10 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2017, Vol.21 No.2 5 179-188 (10 pages)

JuHwanKim, Da-HyeonYu, HakRimKim 저
...
- 3,000원
but not in the cortex following 4 weeks of RF exposure. Taken together, the present study indicates that monthly exposure to RF-EMF induces autophagy in the cerebral cortex and suggests that autophagic degradation in cortical neurons against a stress of 835 MHz RF during 4 weeks could correspond to adaptation to the RF stress environment. However, activation of apoptosis rather than autophagy in the brainstem is suggesting the differential responses to the RF-EMF stresses in the brain system.
137.

Effect of subcutaneous treatment with human umbilical cord blood-derived multipotent stem cells on peripheral neuropathic pain in rats

MinJuLee, TaeGyoonYoon, MoonkyuKang, HyunJeongKim, KyungSunKang 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2017, Vol.21 No.2 2 153-160 (8 pages)

MinJuLee, TaeGyoonYoon, MoonkyuKang, HyunJeongKim, KyungSunKang 저
...
- 3,000원
In this study, we aim to determine the in vivo effect of human umbilical cord blood-derived multipotent stem cells (hUCB-MSCs) on neuropathic pain, using three, principal peripheral neuropathic pain models. Four weeks after hUCBMSC transplantation, we observed significant antinociceptive effect in hUCB-MSC– transplanted rats compared to that in the vehicle-treated control. Spinal cord cells positive for c-fos, CGRP, p-ERK, p-p 38, MMP-9 and MMP 2 were significantly decreased in only CCI...
138.

High fat diet confers vascular hyper-contractility against angiotensin II through upregulation of MLCK and CPI-17

JeeInKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2017, Vol.21 No.1 12 99-106 (8 pages)

JeeInKim 저
...
- 3,000원
Obesity is a critical risk factor for the hypertension. Although angiotensin II (Ang II) in obese individuals is known to be upregulated in obesity-induced hypertension, direct evidence that explains the underlying mechanism for increased vascular tone and consequent increase in blood pressure (BP) is largely unknown. The purpose of this study is to investigate the novel mechanism underlying Ang II-induced hyper-contractility and hypertension in obese rats. Eight-week old male Sprague-Dawley...
139.

Seasonal acclimation in sudomotor function evaluated by QSART in healthy humans

YoungOhShin, Jeong-BeomLee, Jeong-HoKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2016, Vol.20 No.5 7 499-505 (7 pages)

YoungOhShin, Jeong-BeomLee, Jeong-HoKim 저
...
- 3,000원
The quantitative sudomotor axon reflex testing (QSART) is a classic test of routine postganglionic sudomotor function. We investigated sudomotor function by QSART after summer (July 2012) and winter (January 2013) seasonal acclimation (SA) in the Republic of Korea. QSART with acetylcholine (ACh) iontophoresis were performed to determine directly activated (DIR) and axon reflex-mediated (AXR1, 2) sweating rate. Onset time of axon reflex, activated sweat gland density (ASGD), activated sweat gland...
140.

p53 signaling is involved in leptin-induced growth of hepatic and breast cancer cells

MohanShrestha, Pil-HoonPark 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 12 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2016, Vol.20 No.5 6 487-498 (12 pages)

MohanShrestha, Pil-HoonPark 저
...
- 4,100원
Leptin, an adipokine predominantly produced from adipose tissue, is well known to induce tumor growth. However, underlying molecular mechanisms are not established yet. While p53 has long been well recognized as a potent tumor suppressor gene, accumulating evidence has also indicated its potential role in growth and survival of cancer cells depending on experimental environments. In the present study, we examined if p53 signaling is implicated in leptin-induced growth of cancer cells. Herein, we...

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