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131.

Effects of Antioxidants on the Gamma-Radiation Damage of the Cultured Vascular Smooth Mucle Cells of Rat Aorta

Jong-DooLee, Hyoung-ChulChoi, Young-JinKang, Myung-SeKim, Kwang-YounLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2007, Vol.11 No.5 5 189-195 (7 pages)

Jong-DooLee, Hyoung-ChulChoi, Young-JinKang, Myung-SeKim, Kwang-YounLee 저
...
- 3,000원
To study the protective effects of antioxidants on the radiation damages of the cells, vascular smooth muscle cells (VSMC) from thoracic aorta of Sprague-Dawley rats were cultured and irradiated with gamma-ray. Cell viability was measured by direct cell counting and MTT assay, and flow cytometry was performed to measure fractional distributions of the cells. Gamma-ray irradiation inhibited cell proliferations accompanied with decreased G1 phase and increased S- and G2/M phases, and the maximum...
132.

Neurovascular Mechanisms in Stroke, Neurodegeneration and Recovery

EngH.Lo 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2006, Vol.10 No.5 1 223-230 (8 pages)

EngH.Lo 저
...
- 3,000원
The emerging concept of the“neurovascular unit”may enable a powerful paradigm shift for neuroscience. Instead of a pure focus on the“neurobiology”of disease, an opportunity now exists to return to a more integrative approach. The neurovascular unit emphasizes that signaling between vascular and neuronal compartments comprise the basis for both function and dysfunction in brain. Hence, brain disorders are not just due to death of neurons, but instead manifested as cell signaling perturbations...
133.

Conditioned Medium from Dying Smooth Muscle Cell Induced Apoptotic Death

MoonHyunBu, KyeongAhLee, KoanHoiKim, ByungYongRhim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2005, Vol.9 No.6 1 315-322 (8 pages)

MoonHyunBu, KyeongAhLee, KoanHoiKim, ByungYongRhim 저
...
- 3,000원
In this study, the authors investigated whether death of vascular smooth muscle cell (VSMC) had a pathological pertinence. Conditioned media obtained from rat aorta smooth muscle cell (SMC) that were induced death by expressing FADD in the absence of tetracycline (FADD-SMC) triggered death of normal SMC. DNA fragmentation and caspase-3 activation were observed in dying SMC by conditioned media. FADD-SMC showed transcriptional activation of tumor necrosis factor (TNF)-α. Conditioned medium...
134.

Regulation of L-type Calcium Channel Current by Somatostatin in Guinea-Pig Gastric Myocytes

YoungChulKim, JaeHoonSim, SangJinLee, TongMookKang, SungJoonKim, SeungRyulKim, SeiJinYoun, SangJeonLee, Wen-XieXu6, InsukSo, KiWhanKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2005, Vol.9 No.2 5 103-108 (6 pages)

YoungChulKim, JaeHoonSim, SangJinLee, TongMookKang, SungJoonKim, SeungRyulKim, SeiJinYoun, SangJeonLee, Wen-XieXu6, InsukSo, KiWhanKim 저
...
- 3,000원
and ⁣11⁑1.9 mV in SS treated groups (respectively, n=5). The same values of half-inactivation were ⁣35⁑1.4 mV and ⁣35⁑1.9 mV (respectively, n=5). There was no significant difference in activation and inactivation kinetics of IBa by SS. Inhibitory effect of SS on IBa was significantly reduced by either dialysis of intracellular solution with GDPβS, a non-hydrolysableG protein inhibitor, or pretreatment with pertussis toxin (PTX). SS also decreased contraction ...
135.

Hyperthermia-induced Apoptosis is Independent upon DNA Strand Breaks in Human Lymphoid Cells

HwaJinJung, WonHyeKa, JeeNaHwang, YoungRokSeo 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2004, Vol.8 No.6 9 345-350 (6 pages)

HwaJinJung, WonHyeKa, JeeNaHwang, YoungRokSeo 저
...
- 3,000원
Heat shock (43oC for 60 minutes) is sufficient to induce apoptosis in a wide number of cell lines. In this study, we asked whether DNA strand breaks are responsible for this phenomenon. Using the highly sensitive comet assay for DNA damage detection, we were unable to demonstrate DNA breaks immediately after heat shock in Raji human lymphoid cells. It showed that DNA breaks were not necessary for hyperthermic apoptosis, since its activity is indicative of DNA lesions. Here, we present a...
136.

The Effect of Ghrelin on Ca2+ Concentration in Thyroid FRTL-5 Cells

ByungJooKim, YoungJooPark, DoJoonPark, InsukSo, KiWhanKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2004, Vol.8 No.4 4 195-200 (6 pages)

ByungJooKim, YoungJooPark, DoJoonPark, InsukSo, KiWhanKim 저
...
- 3,000원
which is released from the stomach and neurons in the hypothalamic arcuate nucleus (ARC), and potently stimulates growth hormone release and food intake. In the present study, we investigated the effect of ghrelin on [Ca2⁢]i in thyroid FRTL-5 cells. Ghrelin (5 nM) increased [Ca2⁢]i and TSH (1 unit/l) had an additive effect on [Ca2⁢]i when extracellular normal solution was 1.1mM Ca2⁢ containing Coon's modified Ham's F12 medium. When Ca2⁢-free medium containing 2 mM...
137.

Physiological, Pharmacological and Toxicological Implications of Heterodimeric Amino Acid Transporters

YoshikatsuKanaiHitoshiEndou 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 12 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2004, Vol.8 No.3 1 117-128 (12 pages)

YoshikatsuKanaiHitoshiEndou 저
...
- 4,100원
The heterodimeric amino acid transporter family is a subfamily of SLC7 solute transporter family which includes 14-transmembrane cationic amino acid transporters and 12-transmembrane heterodimeric amino acid transporters. The members of heterodimeric amino acid transporter family are linked via a disulfide bond to single membrane spanning glycoproteins such as 4F2hc (4F2 heavy chain) and rBAT (related to b0, ⁢-amino acid transporter). Six members are associated with 4F2hc and one is linked...
138.

Stretch-activated K+ Channels in Rat Atrial Myocytes

JaeBoumYoum 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2003, Vol.7 No.6 8 341-318 (8 pages)

JaeBoumYoum 저
...
- 3,000원
Mechanical stimuli to the cardiac myocytes initiate many biochemical and physiological events. Stretch-activated cation channels have been suggested to mediate these events. In this study, cell-attached and inside-out excised-patch clamp methods were used to identify stretch-activated cation channels in adult rat atrial myocytes. Channel openings were increased in cell-attached configuration when negative pressure was applied to the pipette, and also in inside-out excised patches by negative...
139.

Involvement of NAD(P)H Oxidase in a Potential Link between Diabetes and Vascular Smooth Muscle Cell Proliferation

HyeYoungJeong, MiRanYun, ChiDaeKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2003, Vol.7 No.2 9 103-109 (7 pages)

HyeYoungJeong, MiRanYun, ChiDaeKim 저
...
- 3,000원
The cellular mechanisms that contribute to the acceleration of atherosclerosis in diabetes are poorly understood. Therefore, the potential mechanisms involved in the diabetes-dependent increase in vascular smooth muscle cell (VSMC) proliferation was investigated. Using primary culture of VSMC from streptozotocin-induced diabetic rat aorta, cell proliferation assay showed two-fold increase in cell number accompanied with enhanced superoxide generation compared to normal VSMC, 2 days after...
140.

Inhibition of NF-κB Activation Increases Oxygen-Glucose Deprivation-Induced Cerebral Endothelial Cell Death

JinuLee, ChulHoonKim, KyuDaeShim, YoungSooAhn 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2003, Vol.7 No.2 3 65-71 (7 pages)

JinuLee, ChulHoonKim, KyuDaeShim, YoungSooAhn 저
...
- 3,000원
Increasing evidences suggest that ischemia-induced vascular damage is an integral step in the cascade of the cellular and molecular events initiated by cerebral ischemia. In the present study, employing a mouse brain endothelioma-derived cell line, bEnd.3, and oxygen-glucose deprivation (OGD) as an in vitro stroke model, the role of nuclear factor kappa B (NF-κB) activation during ischemic injury was investigated. OGD was found to activate NF-κB and to induce bEnd.3 cell death in a...

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