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A Study on the Na+/Ca2+ Exchange Mechanism in the Smooth Muscle of Guinea-pig Stomach
Kim, Eui-Yong, Han, Jin, Kim, Ki-Whan 대한생리학회 대한생리학회지 14 Pages
대한생리학회 대한생리학회지 1992, 제 26권 제 1호 6 55-68 (14 pages)
The effects of changes in extracellular Na+ and Ca+ concentration on the membrane potential and contractility were studied in the antral circular muscle of guinea pig stomach in order to elucidate the existence and the nature of Na+/Ca2+ exchange mechanism. All experiments were performed in tris buffered Tyrode solution which was aerated with 100% O2 and kept at 35℃. The treatment of 10-5 ouabain was performed to induce intracellular Na+ loading prior to the start of experiment. The results... -
Cl--sensitive Component of Ca2+-activated Tail Current in Rabbit Atrial Myocytes
Park, Choon-Ok, So, In-Suk, Ho, Won-Kyung, Kim, Woo-Gyeum, Earm, Yung-E 대한생리학회 대한생리학회지 10 Pages
대한생리학회 대한생리학회지 1992, 제 26권 제 1호 3 27-36 (10 pages)
We used the whole cell patch clamp technique to examine the ionic basis for the tail current after depolarizing pulse in single atrial myocytes of the rabbit. We recorded the tail currents during various repolarizations after short depolarizing pulse from a holding potential of -70 mV. The potassium currents were blocked by external 4-aminopyridine and replacement of internal potassium with cesium. The current was reversed to the outward direction above +10 mV. High concentrations of... -
Ionic Dependence and Modulatory Factors of the Background Current Activated by Isoprenaline in Rabbit Ventricular Cells
Leem, Chae-Hun, Lee, Suk-Ho, So, In-Suk, Ho, Won-Kyung, Earm, Yung-E 대한생리학회 대한생리학회지 12 Pages
대한생리학회 대한생리학회지 1992, 제 26권 제 1호 2 15-26 (12 pages)
In order to elucidate the properties of the background current whole cell patch clamp studies were performed in rabbit ventricular cells. Ramp pulses of ±80 mV from holding potential of 40 mV(or 20 mV) at the speed of 0.8 V/sec were given every 30 sec(or 10 sec) and current-voltage diagrams(I-V curve) were obtained. For the activation of the background current isoprenaline, adenosine 3 ,5 -cyclic monophosphate(dBcAMP), guanosine 3 ,5 -cyclic monophosphate(cGMP), and N6-2 -o-dibutyryladenosine 3... -
Effect of Renal Ischemia in Tetraethylammonium Transport in Rabbit Renal Coritcal Slices
Joo, Woo-Sik, Nam, Yun-Jeong, Jung, Jin-Sup, Kim, Yong-Keun 대한생리학회 대한생리학회지 8 Pages
대한생리학회 대한생리학회지 1991, 제 25권 제 2호 7 171-178 (8 pages)
This study was carried out to determine effect of acute renal ischemia on transport function of organic cation, tetraethylammonium (TEA), in rabbit kidney proximal tubule. Clamping of the renal artery for 30 and 60 min produced a polyuria which was accompanied by an increase in Na+ excretion. The capacity of kidney cortical slices to accumulate TEA was increased after 30 and 60 min of ischemia. When blood flow was restored for 30 min after 30 and 60 min of ischemia, the augmented TEA uptake was... -
Mechanisms of Contraction Induced by Sodium Depletion in the Rabbit Renal Artery
Kim, Se-Hoon, Chang, Seok-Jong, 대한생리학회 대한생리학회지 12 Pages
대한생리학회 대한생리학회지 1991, 제 25권 제 2호 6 159-170 (12 pages)
In the rabbit renal artery, mechanisms of contraction by sodium depletion were investigated. The helical strips of isolated renal artery were immersed in the Tris-buffered salt solution. The contractions were recorded isometrically using a strain-gauge transducer. Na-free solution (Na was substituted by Li, choline or sucrose) produced contractions which were dependent on the nature of the Na substitutes. Na-free solution (choline) produced the contraction in ouabain-pretreated artery (Na loaded... -
Short- and Long-term Effects of Potassium on Renin-Aldosterone System in Hypertensive Rats Fed with Different Amounts of Sodium
Kim, Sook-Young, Yang, Eun-Kyung, Park, Jae-Sik, Lee, Won-Jung, Kim, Suhn-Hee 대한생리학회 대한생리학회지 12 Pages
대한생리학회 대한생리학회지 1991, 제 25권 제 1호 7 69-80 (12 pages)
To evaluate the acute and chronic effects of potassium on aldosterone response to different amounts of sodium intake, two series of experiments were conducted. In the first series of experiments, when the plasma K level was increased acutely by KCI infusion (20 μg/kg/min for 20 min), plasma aldosterone concentration increased in both low Na and high Na groups. However, the aldosterone response to K infusion was significantly greater in the low Na than in the high Na groups. In the second series... -
고양이 회장 종주근에서 Na-Ca 교환 기전의 특성에 관한 연구
우재석(Woo, Jae-Suk), 서덕준(Suh, Duk-Joon), 김용근(Kim, Yong-Keun), 이상호(Lee, Sang-Ho) 대한생리학회 대한생리학회지 16 Pages
대한생리학회 대한생리학회지 1989, 제 23권 제 2호 2 237-252 (16 pages)
고양이 회장 종주근에서 세포막 소포를 분리하여 Na+의 농도 경사에 의존하여 일어나는 Ca2+ 이동의 특성에 대하여 연구하였다. 막소포 내부에서 외부로 향하는 Na+의 농도 경사 존재시 Ca2+의 축적이 현저히 증가하여 Na+ 의존성 Ca2+ 축적을 보였으며, 이는 외부용액에 Na+ ionophore인 monensin을 처리시 소실되었다. 한편 이러한 Ca2+ 축적의 증가 작용은 Na+에 특이적이었으며 K+, Li+, Rb+, Cs+ 및 choline이온은 Na+의 작용을 대치하지 못하였다. Ba2+, Sr2+, Mn2+ 및 Cd2+ 등의 2가 양이온들은 0.5 mM의 농도에서 Na+ 의존성 Ca2+... -
Myogenic Autoregulation of Coronary Vessels and Heterometric Autoregulation of the Myocardium
Doring, H.J., Schlicht, I., Hiller, V., Jiang, X.R. 대한생리학회 대한생리학회지 12 Pages
대한생리학회 대한생리학회지 1989, 제 23권 제 2호 1 225-236 (12 pages)
1) At the isolated perfused guinea-pig and rat heart heterometric autoregulation of the myocardium and myogenic autoregulation of the coronary vessels were induced by means of stepwise increases of perfusion pressure. 2) According to this loading test Frank-Starling function curves of the left ventricle and pressure-flow curves of the coronary vessels can be drawn. This graphic evaluation gives more information about the condition of the heart and the coronary vessels than simple evaluation... -
심근 정지 용액이 심근의 에너지원에 미치는 영향
박혜수(Park, Hye-Soo), 박소라(Park, So-Ra), 이영호(Lee, Young-Ho), 김인숙(Kim, In-Sook), 서창국(Suh, Chang-Kook), 강복순(Kang, Bok-Soon), 대한생리학회 대한생리학회지 10 Pages
대한생리학회 대한생리학회지 1989, 제 23권 제 1호 11 109-118 (10 pages)
심근정지용액의 조성이 심근정지 및 심근정지 후 회복기의 에너지원에 미치는 영향을 조사하기 위해 guinea pig 심실 균질액에서 adenosine triphosphate (ATP), creatine phosphate (CP) 및 lactic acid (LA)의 변화를 관찰하여 다음과 같은 결과를 얻었다. 1) ATP 및 CP 양은 심근정지동안은 감소하고 회복기에는 다시 증가하였으며, 심근정지 후 정상용액으로 30분간 회복시켰을 때에는 ATP 양의 회복이 CP에 비해 느린것을 알 수 있었다. 2) LA 양은 심근정지동안은 증가하고 회복기에는 다시 감소하였다. 3) 심근정지 후 회복시간을...
