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The Excitatory Mechanism of Substance P in the Antral Circular Muscle of Guinea Pig Stomach
Jun, Jae-Yeoul, Kim, Sung-Joon, Choi, Youn-Baik, Kim, Ki-Whan 대한생리학회 대한생리학회지 10 Pages
대한생리학회 대한생리학회지 1994, 제 28권 제 1호 5 51-60 (10 pages)
50mV in 10mV steps and this effect was blocked by the addition of an antagonist. Also Substance P increased transient and spontaneous oscillatory K+ outward currents. The enhanced outward currents were abolished by apamin in dispersed single cells. These results suggest that the depolarization of membrane potential by Substance P activates voltage-dependent Ca2+ channels, which represents an excitatory response in the antral circular muscle and led to an increase in Ca2+ activated K+ currents -
Effects of Centrally Administered Angiotensin ll Receptor Antagonists on the Cardiovascular and Hormonal Responses to Hemorrhage in Conscious SHR
Seo, Il-Sook, Yang, Eun-Kyoung, Park, Jae-Sik, Kim, Hyeong-Jin, Lee, Won-Jung 대한생리학회 대한생리학회지 10 Pages
대한생리학회 대한생리학회지 1993, 제 27권 제 2호 10 217-226 (10 pages)
cerebrospinal fluid (aCSF) with or without losartan (DuP 753), a specific Ang ll receptor subtype I (AT1) antagonist and saralasin, a combined AT1/AT2 antagonist was administered into the cerebral lateral ventricle. Hemorrhage was performed at a rate of 3 ml/kg/min far 5 min. Intracerebroventricular administration of losartan and saralasin had no effect on the basal blood pressure. However, in response to acute hemorrhage, central Ang ll antagonists produced a remarkably greater fall in blood... -
Role of Na+-K+ Pump on Endothelium-dependent Relaxation
Sung, Sang-Hyun, Roh, Joon-Ryang, Park, Tae-Sic, Suh, Suk-Hyo, Hwang, Sang-Ik, Kim, Ki-Whan 대한생리학회 대한생리학회지 10 Pages
대한생리학회 대한생리학회지 1993, 제 27권 제 2호 8 199-208 (10 pages)
To study the underlying mechanism through which the endothelium-dependent relaxation is inhibited by blocking the Na+ -K+ pump, the effects of Na+ -K+ pump blockade on the release of EDRF and its relaxing activity were examined, using organ bath study, bioassay technique, and cGMP measurement. Endothelium-dependent relaxation was attenuated by blocking the Na+ -K+ pump in the vascular ring with intact endothelium. In bioassay experiment EDRF release was decreased with the blockade of the Na+... -
Cardiovascular Neurons Mediating Somatosympathetic Reflex in Rostral Ventrolateral Medulla
Goo, Yong-Sook, Kim, Sang-Jeong, Kim, Jun, Sung, Ho-Kyung 대한생리학회 대한생리학회지 14 Pages
대한생리학회 대한생리학회지 1993, 제 27권 제 2호 7 185-198 (14 pages)
1 Hz and C-intensity (10 mA, 0.5 ms), 20 Hz to elicit the depressor, and pressor responses of the SSR, respectively. Simultaneous measurement of CVN firing rate was made. Experimental results are summarized as follows. 1) 20 out of 98 CVNs had axonal projections to the spinal cord and 17 out of 98 CVNs showed FR changes during SSR. 2) Response patterns of FR and BP during SSR were classified into 8 types. 3) These 8 different response patterns could be further classified into those from pressor... -
Effect of Cyclic GMP on the Calcium Current in Rabbit Ventricular Myocytes
Han, Jin, Leem, Chae-Hun, Ahn, Chul-Soo, So, In-Suk, Kim, Eui-Yong, Ho, Won-Kyung, Earm, Yung-E 대한생리학회 대한생리학회지 12 Pages
대한생리학회 대한생리학회지 1993, 제 27권 제 2호 4 151-162 (12 pages)
In order to investigate the effect of intracellular cyclic GMP on calcium current the whole-cell patch clamp technique with internal perfusion method was used in isolated ventricular myocytes of the rabbit. Cyclic GMP, 8-bromo-cyclic GMP, cyclic AMP, isoprenaline and forskolin were perfused into cells and their effects on calcium current were analysed by applying depolarizing step pulses of + 10 mV in amplitude far 300 msec from holding potential of - 40 mV. Not only cyclic AMP (100 μM) but... -
Effect of Dopamine on the Ca2+-dependent K+ currents in Isolated Single Gastric Myocytes of the Guinea-pig
Rhee, Poong-Lyul, Lee, Sang-Jin, Kim, Sung-Joon, So, In-Suk, Hwang, Sang-Ik, Kim, Ki-Whan 대한생리학회 대한생리학회지 12 Pages
대한생리학회 대한생리학회지 1993, 제 27권 제 2호 3 139-150 (12 pages)
We have reported that dopamine potentiates spontaneous contractions dose-dependently in guinea-pig antral circular muscle strips (Hwang et al, 1991). To clarify the underlying excitatory mechanism of dopamine on the gastric smooth muscle, the effects of dopamine on voltage-dependent Ca2+ currents and Ca2+ -dependent K+ currents were observed in enzymatically dispersed guinea-pig gastric myocytes using the whole-cell voltage-clamp technique. Experiments were also done using isometric tension... -
Effects of Noradrenaline on the Spontaneous Contraction and Ionic Current in the Antral Circular Muscle of Guinea-pig Stomach
Jun, Jae-Yeoul, Lee, Sang-Jin, Kim, Sung-Joon, Suh, Jae-Yul, So, In-Suk, Hwang, Sang-Ik, Kim, Ki-Whan 대한생리학회 대한생리학회지 8 Pages
대한생리학회 대한생리학회지 1993, 제 27권 제 2호 1 115-122 (8 pages)
There is evidence that noradrenaline enhances spontaneous contractions dose-dependently in guinea-pig antral circular muscle. To investigate the mechanism of this excitatory action, slow waves and membrane currents were recorded using conventional microelectrode techniques in muscle strips and the whole cell patch clamp technique in isolated gastric myocytes. On recording slow waves, noradrenaline (10-5 M) induced the hyperpolarization of the membrane potential, although the shape of the slow... -
Voltage-Dependent Ionic Currents and Their Regulation by GTP and Phorbol Ester in the Unfertilized Eggs of Mouse and Hamster
Kim, Ik-Hyun, Kim, Yang-Mi, Haan, Jae-Hee, Park, Choon-Ok, Hong, Seong-Geun 대한생리학회 대한생리학회지 14 Pages
대한생리학회 대한생리학회지 1993, 제 27권 제 1호 9 93-106 (14 pages)
The present study was performed to investigate the properties of ionic currents elicited by voltage pulses in the unfertilized eggs of mouse and hamster by using the whole cell voltage clamp techniques and to find out if there are any differences in properties between eggs of the two rodents. In addition, the modulatory effect of G proteins and protein kinase C (PKC) on the ionic channels were observed. The inward current in hamster eggs was shown to be due to Ca2+ current (ica)). The current... -
Cocaine-induced Changes in Functional Connectivities between Simultaneously Recorded Single Neurons in the SI Cortex and the VPL Thalamus of Conscious Rats
Shin, Hyung-Cheul, Park, Hyoung-Jin, Oh, Yang-Seok, Chapin, John K. 대한생리학회 대한생리학회지 14 Pages
대한생리학회 대한생리학회지 1993, 제 27권 제 1호 8 79-92 (14 pages)
The present study was carried out to determine the effects of cocaine (0.25, 1.0, 10.0 mg/kg, i.p.) on the interactions between spontaneously active neurons within ensembles of simultaneously recorded neurons in the primary somatosensory cortex (Sl, n= 20) and the ventroposterolateral (VPL, n= 16) thalamic nucleus of awake rats. Spike triggered cross correlation histograms were constructed between pairs of simultaneously recorded neurons. Among 101 neuronal pairs analyzed, 22.7% showed... -
Acute and Chronic Effects of Ethanol on the Cardiovascular and Hormonal Responses to Hemorrhage in Conscious Normotensive and Spontaneously Hypertensive Rats
Park, Yoon-Yub, Lee, Joong-Hee, Park, Jae-Sik, Yang, Eun-Kyoung, Ahn, Dong-Kuk, Kim, Hyeong-Jin, Lee, Won-Jung, 대한생리학회 대한생리학회지 12 Pages
대한생리학회 대한생리학회지 1993, 제 27권 제 1호 7 67-78 (12 pages)
smaller elevation in heart rate in response to a hemorrhage. The degree of MAP reduction was significantly greater in SHR than in Wistar rats. Both the acute and chronic EOH administration attenuated the baroreceptor reflex and retarded MAP recovery, again the trend being much more prominent in SHR. The increase in plasma vasopressin and lenin concentrations after hemorrhage were intensified by the chronic EOH administration. SHR showed a greater vasopressin response but a smaller lenin response...


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