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141.

대사증후군 개선을 위한 뽕잎, 오디, 누에 분말의 혼합 비율 최적화

김민주, 김현숙, 김애정 한방비만학회 대한한방비만학회지 13 Pages

한방비만학회 대한한방비만학회지 2018, 제 18권 제 2호 4 83-95 (13 pages)

김민주, 김현숙, 김애정 저
...
- 4,200원
142.

비만에 작용하는 주요 본초의 항비만 효과 분석

송미영(Mi Young Song), 김호준(Ho Jun Kim) 한방비만학회 대한한방비만학회지 7 Pages

한방비만학회 대한한방비만학회지 2013, 제 13권 제 2호 1 51-57 (7 pages)

송미영(Mi Young Song), 김호준(Ho Jun Kim) 저
...
- 3,000원
143.

동물실험에서 인삼의 항비만 효과: 체계적 고찰과 메타분석을 위한 연구 프로토콜

조재흥(Jae heung Cho), 김고운(Koh woon Kim), 박혜성(Hye sung Park), 윤예지(Ye ji Yoon), 송미연(Mi yeon Song) 한방비만학회 대한한방비만학회지 8 Pages

한방비만학회 대한한방비만학회지 2017, 제 17권 제 1호 5 37-44 (8 pages)

조재흥(Jae heung Cho), 김고운(Koh woon Kim), 박혜성(Hye sung Park), 윤예지(Ye ji Yoon), 송미연(Mi yeon Song) 저
...
- 3,000원
최근 비만이 전 세계적인 문제로 대두되면서 임상 연구의 해석에 필요한 중요 자료를 제시해 줄 수 있는 동물 모델을 이용한 생리학적 기전 연구에 대한 관심이 높아지고 있다. 인삼은 많은 동물 실험에서 항비만 또는 항당뇨 효과가 보고되었으나 인체의 임상에서 비만을 연구한 논문은 거의 없는 실정이다. 이 연구에서는 신체계측치수와 대사지표를 활용한 동물 모델에서의 인삼의 항비만 효과의 근거수준을 평가하고자 한다. 전임상 단계에서 비만에 대한 인삼의 효과를 연구한 대조군 연구, 비교 연구를 포함시키고자 한다....
144.

Inhibition of voltage-dependent K+ current in rabbit coronary arterial smooth muscle cells by the class Ic antiarrhythmic drug propafenone

Jin Ryeol An, Hongliang Li, Mi Seon Seo, Won Sun Park 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2018, Vol.22 No.5 13 597-605 (9 pages)

Jin Ryeol An, Hongliang Li, Mi Seon Seo, Won Sun Park 저
...
- 3,000원
In this study, we demonstrated the inhibitory effect of the Class Ic antiarrhythmic agent propafenone on voltage-dependent K+ (Kv) channels using freshly isolated coronary artery smooth muscle cells from rabbits. The Kv current amplitude was progressively inhibited by propafenone in a dose-dependent manner, with an apparent IC50 value of 5.04±1.05 μM and a Hill coefficient of 0.78±0.06. The application of propafenone had no significant effect on the steady-state activation and inactivation...
145.

Lysophosphatidic acid enhances breast cancer cells-mediated osteoclastogenesis

Ju-Suk Nam, Ashish Ranjan Sharma, Lich Thi Nguyen, Supriya Jagga, Yeon-Hee Lee, Garima Sharma, Sang-Soo Lee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2018, Vol.22 No.5 4 503-511 (9 pages)

Ju-Suk Nam, Ashish Ranjan Sharma, Lich Thi Nguyen, Supriya Jagga, Yeon-Hee Lee, Garima Sharma, Sang-Soo Lee 저
...
- 3,000원
Lysophosphatidic acid (LPA) is known to play a critical role in breast cancer metastasis to bone. In this study, we tried to investigate any role of LPA in the regulation of osteoclastogenic cytokines from breast cancer cells and the possibility of these secretory factors in affecting osteoclastogenesis. Effect of secreted cytokines on osteoclastogenesis was analyzed by treating conditioned media from LPA-stimulated breast cancer cells to differentiating osteoclasts. Result demonstrated that...
146.

Caffeic acid phenethyl ester protects against photothrombotic cortical ischemic injury in mice

SunAeHwang, ChiDaeKim, WonSukLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 10 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2018, Vol.22 No.1 11 101-110 (10 pages)

SunAeHwang, ChiDaeKim, WonSukLee 저
...
- 3,000원
In this study, we aimed to investigate the neuroprotective effects of caffeic acid phenethyl ester (CAPE), an active component of propolis purified from honeybee hives, on photothrombotic cortical ischemic injury in mice. Permanent focal ischemia was achieved in the medial frontal and somatosensory cortices of anesthetized male C57BL/6 mice by irradiation of the skull with cold light laser in combination with systemic administration of rose bengal. The animals were treated with CAPE (0.5-5...
147.

Hydroquinone suppresses IFN-β expression by targeting AKT/IRF3 pathway

YongKim, HanGyungKim, SangYunHan, DeokJeong, WooSeokYang, Jung-IlKim, JiHyeKim, Young-SuYi, JaeYoulCho 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2017, Vol.21 No.5 9 547-554 (8 pages)

YongKim, HanGyungKim, SangYunHan, DeokJeong, WooSeokYang, Jung-IlKim, JiHyeKim, Young-SuYi, JaeYoulCho 저
...
- 3,000원
Previous studies have demonstrated the role of hydroquinone (HQ), a hydroxylated benzene metabolite, in modulating various immune responses; however,its role in macrophage-mediated inflammatory responses is not fully understood. In this study, the role of HQ in inflammatory responses and the underlying molecular mechanism were explored in macrophages. HQ down-regulated the expression of interferon (IFN)-β mRNA in LPS-stimulated RAW264.7 cells without any cytotoxicity and suppressed interferon...
148.

Effects of tianeptine on symptoms of fibromyalgia via BDNF signaling in a fibromyalgia animal model

HwayoungLee, JiyunIm, HansolWon, WooyoungNam, YoungOckKim, SangWonLee, SanghyunLee, Ik-HyunCho, Hyung-KiKim, Jun-TackKwon, Hak-JaeKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 10 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2017, Vol.21 No.4 1 361-370 (10 pages)

HwayoungLee, JiyunIm, HansolWon, WooyoungNam, YoungOckKim, SangWonLee, SanghyunLee, Ik-HyunCho, Hyung-KiKim, Jun-TackKwon, Hak-JaeKim 저
...
- 3,000원
Previous reports have suggested that physical and psychological stresses may trigger fibromyalgia (FM). Stress is an important risk factor in the development of depression and memory impairments. Antidepressants have been used to prevent stress-induced abnormal pain sensation. Among various antidepressants, tianeptine has been reported to be able to prevent neurodegeneration due to chronic stress and reverse decreases in hippocampal volume. To assess the possible effect of tianeptine on FM...
149.

JS-III-49, a hydroquinone derivative, exerts anti-inflammatory activity by targeting Akt and p38

Young-SuYi, Mi-YeonKim, JaeYoulCho 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2017, Vol.21 No.3 9 345-352 (8 pages)

Young-SuYi, Mi-YeonKim, JaeYoulCho 저
...
- 3,000원
activities of Src and Syk, which are upstream kinases of Akt, in LPSstimulatedRAW264.7 cells. Moreover, JS-III-49 suppressed the nuclear translocation of c-Fos, one of the components of AP-1, by specifically targeting p38, an upstream mitogen-activated protein kinase (MAPK) in the AP-1 pathway in LPS-stimulated RAW264.7 cells. These results suggest that JS-III-49 plays an anti-inflammatory role in LPS-stimulated macrophages by targeting Akt and p38 in the NF-κB and AP-1 pathways, respectively.
150.

Nortriptyline, a tricyclic antidepressant, inhibits voltage-dependent K+ channels in coronary arterial smooth muscle cells

SungEunShin, HongliangLi, HanSolKim, HyeWonKim, MiSeonSeo, Kwon-SooHa, Eun-TaekHan, Seok-HoHong, AmyL.Firth, Il-WhanChoi6, YoungMinBae, Won 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2017, Vol.21 No.2 10 225-232 (8 pages)

SungEunShin, HongliangLi, HanSolKim, HyeWonKim, MiSeonSeo, Kwon-SooHa, Eun-TaekHan, Seok-HoHong, AmyL.Firth, Il-WhanChoi6, YoungMinBae, Won 저
...
- 3,000원
We demonstrated the effect of nortriptyline, a tricyclic antidepressant drug and serotonin reuptake inhibitor, on voltage-dependent K+ (Kv) channels in freshly isolated rabbit coronary arterial smooth muscle cells using a whole-cell patch clamp technique. Nortriptyline inhibited Kv currents in a concentration-dependent manner, with an apparent IC50 value of 2.86±0.52 µM and a Hill coefficient of 0.77±0.1. Although application of nortriptyline did not change the activation curve,...

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