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141.

Acute Effect of Alcohol and Nicotine on 5-Hydroxytryptamine Synthesis and Tryptophan Hydroxylase Expression in Dorsal and Median Raphe of Rats

Mi-HyeonJang, Min-ChulShin, Hyun-KyungChang, Taeck-HyunLee, Khae-HawnKim, Youn-JungKim, Chang-JuKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 4 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2003, Vol.7 No.1 2 5-8 (4 pages)

Mi-HyeonJang, Min-ChulShin, Hyun-KyungChang, Taeck-HyunLee, Khae-HawnKim, Youn-JungKim, Chang-JuKim 저
...
- 1,500원
Alcohol abuse and cigarette smoking have been on the rise worldwide and it has been reported that alcohol and nicotine influence serotonergic neuronal activity in the dorsal raphe. Serotonin (5-hydroxytryptamine, 5-HT) has been implicated in the pathophysiology of various neuropsychiatric disorders. In the present study, the effects of alcohol and nicotine on the synthesis of 5-HT and the expression of tryptophan hydroxylase (TPH), the rate limiting enzyme of 5-HT synthesis, in the dorsal and...
142.

G Protein-Coupled Receptor Signaling in Gastrointestinal Smooth Muscle

UyDongSohn, DongSeokKim, KarnamSMurthy 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 11 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2001, Vol.5 No.4 1 287-297 (11 pages)

UyDongSohn, DongSeokKim, KarnamSMurthy 저
...
- 4,000원
(MLC) kinase and phosphorylation of MLC. The types of contraction and signaling mechanisms mediating contraction differ depending on the region. The involvement of these different mechanisms varies depending on the source of Ca2⁢ and the kinetic of Ca2⁢ mobilization. Ca2⁢ mobilizing agonists stimulate different phospholipases (PLC-β, PLD and PLA2) to generate one or more Ca2⁢ mobilizing messengers (IP3 and AA), and diacylglycerol (DAG), an activator of protein kinase C...
143.

Activation of ATP-sensitive Potassium Channels by the Predominant Metabolite of Isoflurane in Rabbit Ventricular Myocytes

JinHan, NariKim, EuiyongKim, SungjuKim, KangheeCho 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 11 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2001, Vol.5 No.2 7 165-175 (11 pages)

JinHan, NariKim, EuiyongKim, SungjuKim, KangheeCho 저
...
- 4,000원
TFA enhanced channel activity in a concentration-dependent fashion. The concentration of TFA for half-maximal activation and the Hill coefficient were 0.03 mM and 1.2, respectively. TFA did not affect the single channel conductance of KATP channels. Analysis of open and closed time distributions showed that TFA increased burst duration and decreased the interburst interval without changes in open and closed time distributions shorter than 5 ms. TFA diminished ATP sensitivity of KATP channels in ...
144.

Molecular Aspects of Organic Ion Transporters in the Kidney

SeokHoChaHitoshiEndou 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 16 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2001, Vol.5 No.2 1 107-122 (16 pages)

SeokHoChaHitoshiEndou 저
...
- 4,500원
A function of the kidney is elimination of a variety of xenobiotics ingested and wasted endogenous compounds from the body. Organic anion and cation transport systems play important roles to protect the body from harmful substances. The renal proximal tubule is the primary site of carrier-mediated transport from blood into urine. During the last decade, molecular cloning has identified several families of multispecific organic anion and cation transporters, such as organic anion transporter...
145.

N-Type Calcium Channels

KeithS.Elmslie 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2000, Vol.4 No.6 12 525-530 (6 pages)

KeithS.Elmslie 저
...
- 3,000원
larger number of different calcium channels in neurons and (2) many of the different calcium channels have similar kinetic properties. This review uses the N-type calcium channel to illustrate the difficulties in identifying and characterizing calcium channels in neurons. It shows that the discovery of toxins that can specifically block single calcium channel types has made it possible to easily and rapidly discern the physiological roles of the different calcium channels in the neuron. Without...
146.

Cadmium Inhibition of Renal Endosomal Acidification

MooSeongKim, KyoungRyongKim, DoWhanAhn, YangSaengPark 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 10 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2000, Vol.4 No.1 9 63-72 (10 pages)

MooSeongKim, KyoungRyongKim, DoWhanAhn, YangSaengPark 저
...
- 3,000원
Chronic exposure to cadmium (Cd) results in an inhibition of protein endocytosis in the renal proximal tubule, leading to proteinuria. In order to gain insight into the mechanism by which Cd impairs the protein endocytosis, we investigated the effect of Cd on the acidification of renal cortical endocytotic vesicles (endosomes). The endosomal acidification was assessed by measuring the pH gradient-dependent fluorescence change, using acridine orange or FITC-dextran as a probe. In renal endosomes...
147.

Effect of Ethanol on Na+-Pi Uptake in Opossum Kidney Cells Role of Membrane Fluidization and Reactive Oxygen Species

InHoPark, MoonYoungHwang, JaeSukWoo, JinSupJung, YongKeunKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 10 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1999, Vol.3 No.5 10 529-538 (10 pages)

InHoPark, MoonYoungHwang, JaeSukWoo, JinSupJung, YongKeunKim 저
...
- 3,000원
cells were treated with 8% ethanol. Kinetic analysis showed that ethanol increased Km without a change in Vmax of Na⁢-Pi uptake. Inhibitory effect of n-alcohols on Na⁢-Pi uptake was dependent on the length of the hydrocarbon chain, and it resulted from the binding of one molecule of alcohol, as indicated by the Hill coefficient (n) of 0.8-1.04. Catalase significantly prevented the inhibition, but superoxide dismutase and hydroxyl radical scavengers did not alter the ethanol effect. A...
148.

Changes in Phosphate Transporter Activity Evaluated by Phosphonoformic Acid Binding in Cadmium-Exposed Renal Brush-Border Membranes

JinMoChung, DoWhanAhn, KyoungRyongKim, YangSaengPark 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1999, Vol.3 No.5 8 513-519 (7 pages)

JinMoChung, DoWhanAhn, KyoungRyongKim, YangSaengPark 저
...
- 3,000원
Direct exposure of renal tubular brush-border membranes (BBM) to free cadmium (Cd) causes a reduction in phosphate (Pi) transport capacity. Biochemical mechanism of this reduction was investigated in the present study. Renal proximal tubular brush-border membrane vesicles (BBMV) were isolated from rabbit kidney outer cortex by Mg precipitation method. Vesicles were exposed to 50∼200 μM CdCl2 for 30 min, then the phosphate transporter activity was determined. The range of Cd concentration...
149.

Temporal Changes in Neuronal Activity of the Bilateral Medial Vestibular Nuclei Following Unilateral Labyrinthectomy in Rats

ByungRimPark, MoonYoungLee, MinSunKim, SungHoLee, HanJoNa, NamYongDoh 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 10 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1999, Vol.3 No.5 4 481-490 (10 pages)

ByungRimPark, MoonYoungLee, MinSunKim, SungHoLee, HanJoNa, NamYongDoh 저
...
- 3,000원
To investigate the changes in the responses of vestibular neurons with time during vestibular compensation, the resting activity and dynamic responses of type I and II neurons in the medial vestibular nuclei to sinusoidal angular acceleration were recorded following unilateral labyrinthectomy (ULX) in Sprague-Dawley rats. The unitary extracellular neuronal activity was recorded from the bilateral medial vestibular nuclei with stainless steel microelectrodes of 3∼5 MΩ before ULX, and 6, 24,...
150.

Physiological and Pharmacological Characterization of Glutamate and GABA Receptors in the Retina

Xiong-LiYang, YingShen, Ming-HuHan, TaoLu 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1999, Vol.3 No.5 2 461-469 (9 pages)

Xiong-LiYang, YingShen, Ming-HuHan, TaoLu 저
...
- 3,000원
subtype, which predominantly consists of flop splice variants. GABAA and GABAC receptors coexist in bipolar cells and they both show significant desensitization. Kinetics analysis demonstrated that activation, deactivation and desensitization of the GABAC receptor-mediated response of these cells are overall slower than those of the GABAA response. Endogenous modulator Zn2⁢ in the retina was found to differentially modulate the kinetic characteristics of the GABAC and GABAA responses.

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