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141.

Detection of Mitochondrial ATP-Sensitive Potassium Channels in Rat Cardiomyocytes

DangVanCuong, NariKim, EuiyongKim, YoungsukLee, HyunjuKim, SunghyunKang, DaeYoungHur, HyunJoo, YoungShikPark, YongGeunHong, SangkyungLee, J 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2004, Vol.8 No.4 5 201-206 (6 pages)

DangVanCuong, NariKim, EuiyongKim, YoungsukLee, HyunjuKim, SunghyunKang, DaeYoungHur, HyunJoo, YoungShikPark, YongGeunHong, SangkyungLee, J 저
...
- 3,000원
Mitochondrial ATP-sensitive potassium (mitoKATP) channels play a role in early and late ischemic preconditioning. Nevertheless, the subunit composition of mitoKATP channels remains unclear. In this study, we investigated the subunit composition of mitoKATP channels in mitochondria isolated from rat cardiacmyocytes. Mitochondria were visualized using the red fluorescence probe, Mitrotracker Red, while mitoKATP channels were visualized using the green fluorescence probe, glibenclamide-BODIPY. The...
142.

Nitric Oxide-cGMP-Protein Kinase G Pathway Contributes to Cardioprotective Effects of ATP-Sensitive K+ Channels in Rat Hearts

DangVanCuong*, NariKim*, HeeCheolCho, EuiyongKim, JinHan 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2004, Vol.8 No.2 5 95-100 (6 pages)

DangVanCuong*, NariKim*, HeeCheolCho, EuiyongKim, JinHan 저
...
- 3,000원
Ischemic preconditioning (IPC) has been accepted as a heart protection phenomenon against ischemia and reperfusion (I/R) injury. The activation of ATP-sensitive potassium (KATP) channels and the release of myocardial nitric oxide (NO) induced by IPC were demonstrated as the triggers or mediators of IPC. A common action mechanism of NO is a direct or indirect increase in tissue cGMP content. Furthermore, cGMP has also been shown to contribute cardiac protective effect to reduce heart I/R-induced...
143.

Presynaptic Mechanism Underlying Regulation of Transmitter Release by G Protein Coupled Receptors

TomoyukiTakahashi, YoshinaoKajikawa, MasahiroKimura, NaotoSaitoh, TetsuhiroTsujimoto 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2004, Vol.8 No.2 1 69-76 (8 pages)

TomoyukiTakahashi, YoshinaoKajikawa, MasahiroKimura, NaotoSaitoh, TetsuhiroTsujimoto 저
...
- 3,000원
of G protein βγ subunit (Gβγ) into the calyceal terminal mimic and occlude the inhibitory effect of a GPCR agonist on presynaptic Ca2⁢ currents (IpCa), suggesting that Gβγmediates presynaptic inhibition by GPCRs. Among presynaptic GPCRs glutamate and adenosine autoreceptors play regulatory roles in transmitter release during early postnatal period when the release probability (p) is high, but these functions are lost concomitantly with a decrease in p during postnatal development.
144.

The Effect of Carbon Monoxide on L-type Calcium Channel Currents in Human Intestinal Smooth Muscle Cells

InjaLim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2003, Vol.7 No.6 10 357-362 (6 pages)

InjaLim 저
...
- 3,000원
Carbon monoxide (CO) is low molecular weight oxide gas that is endogenously produced under physiological conditions and interacts with another gas, nitric oxide (NO), to act as a gastrointestinal messenger. The aim of this study was to determine the effects of exogenous CO on L-type calcium channel currents of human jejunal circular smooth muscle cells. Cells were voltage clamped with 10 mM barium (Ba2⁢) as the charge carrier, and CO was directly applied into the bath to avoid perfusion...
145.

Effects of γ-Aminobutyric Acid on Intrinsic Cholinergic Action in Exocrine Secretion of Isolated, Perfused Rat Pancreas

YongDeukPark, HyungSeoPark, ZhengYunCui, HyoungJinPark 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2003, Vol.7 No.3 8 169-174 (6 pages)

YongDeukPark, HyungSeoPark, ZhengYunCui, HyoungJinPark 저
...
- 3,000원
was used to block neuronal or cholinergic action. Acetylcholine was infused to mimic cholinergic excitation. GABA (30μM) and muscimol (10μM), given intra-arterially, did not change spontaneous secretion but enhanced cholecystokinin (CCK; 10 pM)-induced secretions of fluid and amylase. GABA (3, 10, 30μM) further elevated EFS-evoked secretions of fluid and amylase dose-dependently. GABA (10, 30, 100μM) also further increased acetylcholine (5μM)-induced secretions of fluid and amylase in a...
146.

Intrinsic Gating in Inward Rectifier Potassium Channels (Kir2.1) with Low Polyamine Affinity Generated by Site Directed Mutagenesis

ISo, , IAshmole, HSoh, CSPark, PJSpencer, MLeyl, PRStanfield, 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 12 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2003, Vol.7 No.3 3 131-142 (12 pages)

ISo, , IAshmole, HSoh, CSPark, PJSpencer, MLeyl, PRStanfield, 저
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- 4,100원
We have studied mutant forms of Kir2.1 in which an aspartate residue (D172), important for gating by intracellular polyamines, is replaced by one of three basic residues (Arg, Lys or His). Such channels are highly selective for K+, but show inward rectification that is a shallow function of voltage compared with that found in wild type. This inward rectification occurs with a reduced affinity for spermine and persists in the absence of polyamines. Though the unitary current-voltage relation...
147.

Ceramide is involved in MPP+-induced Cytotoxicity in Human Neuroblastoma Cells

Eun-JooNam, Hye-SookLee, YoungJaeLee, Wan-SeokJoo, SunghoMaeng, Hye-InIm, Chan-WoongPark, YongSikKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2002, Vol.6 No.6 1 281-286 (6 pages)

Eun-JooNam, Hye-SookLee, YoungJaeLee, Wan-SeokJoo, SunghoMaeng, Hye-InIm, Chan-WoongPark, YongSikKim 저
...
- 3,000원
To understand the cytotoxic mechanism of MPP⁢, we examined the involvement of ceramide in MPP⁢- induced cytotoxicity to human neuroblastoma SH-SY5Y cells. When SH-SY5Y cells were exposed to MPP⁢, MPP⁢ induced dose-dependent cytotoxicity accompanied by 2-fold elevation of intracellular ceramide levels in SH-SY5Y cells. Three methods were used to test the hypothesis that the elevated intracellular ceramide is related to MPP⁢-induced cytotoxicity: C2-ceramide was...
148.

Differential Changes of ATP-sensitive Potassium Channel Current after Hypoxia-reperfusion Treatment in Mouse Neuroblastoma 2a (N2a) Cell

Ji-HoPark 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 4 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2002, Vol.6 No.4 2 183-186 (4 pages)

Ji-HoPark 저
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- 1,500원
Ischemic damage is one of the most serious problems. The openers of KATP channel have been suggested to have an effect to limit the ischemic damage. However, it is not yet clear how KATP channels of a cell correspond to hypoxic damage. To address the question, N2a cells were exposed to two different hypoxic conditions as follows: 6 hours hypoxia followed by 3 hours reperfusion and 12 hours hypoxia followed by 3 hours reperfusion. As the results, 6 hours hypoxic treatment increased...
149.

Activation of ATP-sensitive Potassium Channels by the Predominant Metabolite of Isoflurane in Rabbit Ventricular Myocytes

JinHan, NariKim, EuiyongKim, SungjuKim, KangheeCho 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 11 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2001, Vol.5 No.2 7 165-175 (11 pages)

JinHan, NariKim, EuiyongKim, SungjuKim, KangheeCho 저
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- 4,000원
Background: Recent in vivo experimental evidence suggests that isoflurane-induced cardioprotection may involve KATP channel activation. However, it was demonstrated that isoflurane inhibited KATP channel activities in the inside-out patch mode. To explain this discrepancy, the present investigation tested the hypothesis that a metabolite of isoflurane, trifluoroacetic acid (TFA), contributes to isoflurnae-induced cardioprotection via KATP channel activation during myocardial ischemia and...
150.

The Enhancement of Endotoxin-Induced Nitric Oxide Production by Elevation of Glucose Concentration in Macrophage

HyunGooWoo, Yi-SookJung, EunJooBaik, Chang-HyunMoon, SooHwanLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1999, Vol.3 No.4 10 447-454 (8 pages)

HyunGooWoo, Yi-SookJung, EunJooBaik, Chang-HyunMoon, SooHwanLee 저
...
- 3,000원
The production of nitric oxide (NO) and the expression of inducible nitric oxide synthase (iNOS) are known to be modulated by a variety of factors. Recent study showed that endotoxin-induced NO synthesis and iNOS expression were greatly enhanced by elevation of extracellular glucose concentration in murine macrophages. Although this was suggested to be due to the activation of protein kinase C (PKC) via sorbitol pathway, there was lack of evidence for this speculation. This study was performed...

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