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본문검색 결과만 보기
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Comparison of Ectopic Gene Expression Methods in Rat Neural Stem Cells
WoosukKim, JiHyeonKim, Sun-YoungKong, Min-HyePark, UyDongSohn, Hyun-JungKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2013, Vol.17 No.1 4 23-30 (8 pages)
Neural stem cells (NSCs) have the ability to proliferate and differentiate into various types of cells that compose the nervous system. To study functions of genes in stem cell biology, genes or siRNAs need to be transfected. However, it is difficult to transfect ectopic genes into NSCs. Thus to identify the suitable method to achieve high transfection efficiency, we compared lipid transfection, electroporation, nucleofection and retroviral transduction. Among the methods that we tested, we... -
Stem Cells in Drug Screening for Neurodegenerative Disease
Hyun-JungKim, ChangYunJin 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2012, Vol.16 No.1 1 1-9 (9 pages)
Because the average human life span has recently increased, the number of patients who are diagnosed with neurodegenerative diseases has escalated. Recent advances in stem cell research have given us access to unlimited numbers of multi-potent or pluripotent cells for screening for new drugs for neurodegenerative diseases. Neural stem cells (NSCs) are a good model with which to screen effective drugs that increase neurogenesis. Recent technologies for human embryonic stem cells (ESCs) or induced... -
Cytotoxicities and Quantitative Structure Activity Relationships of B13 Sulfonamides in HT-29 and A549 Cells
SeulKiChanLee, SangMinPark, ChaeukIm 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2011, Vol.15 No.6 14 423-430 (8 pages)
they are made by bioisosterically substituting the carboxyl moiety of B13 with sulfone group. Twenty B13 sulfonamides were evaluated for their in vitro cytotoxicities against human colon cancer HT-29 and lung cancer A549 cell lines using MTT assays. Replacement of the amide group with a sulfonamide group increased cytotoxicity in both cancer cell lines. The sulfonamides with long alkyl chains exhibited activities two to three times more potent than that of B13 and compound (15) had the most pote... -
PTU-처치가 흰쥐대동맥의 수축 및 이완 반응에 미치는 영향
심일청(Il-Chung Shim), 김인겸(In-Kyeom Kim), 김중영(Choong-Young Kim) 대한약리학회 대한약리학잡지 10 Pages
대한약리학회 대한약리학잡지 1990, 제 26권 제 2호 5 135-144 (10 pages)
Propylthiouracil(PTU)을 4주 및 12주간 투여한 흰쥐의 대동맥을 적출하여 혈관수축제와 이완제에 대한 반응을 관찰하여 다음과 같은 결과를 얻었다. PTU를 처치한 실험군에서는 대조군에 비해 현저한 체중저하와 혈중 갑상선호르몬의 감소를 보였다. PTU를 처치한 흰쥐의 대동맥에 대한 norepinephrine (NE)과, calcium및 potassium 이온에 의한 최대수축 반응은 대조군에 비하여 유의하게 감소되었다. 그러나 NE에 대한 중간유효량은 증가되었으나, calcium이온에 대한 중간 유효량은 유의한 차이가 없었다. 그리고 acetylcholine,... -
Indole, Indole-3-calbinol 및 Benzofuran이 간장 microsome과 cytosol의 약물대사 효소 활성도에 미치는 영향
차영남(Young-Nam Cha), 정진호(Jin-Ho Chung), David C. Thompson, Henry S. Heine 대한약리학회 대한약리학잡지 11 Pages
대한약리학회 대한약리학잡지 1985, 제 21권 제 1호 1 1-11 (11 pages)
이물질(xenobiotics) 대사에 관여하는 간장 microsome과 cytosol 효소 활성에 indole, indole-3-carbinol 및 benzofuran이 미치는 영향을 검색하기위하여 마우스에 이들 약물을 각각 5 mmole/kg씩 10일간 투여하여 다음 몇 가지의 성적을 얻었다. Benzofuran은 microsome 효소인 aniline hydroxylase, 7-ethoxycoumarin O-deethylase, p-nitrophenol UDPGA-transferase, epoxide hydrolase와 cytosol 효소인 glutathione S-tranferase, NADH : quinone reductase, UDP-glucose dehydrogenase의 활성도를 증가시켰다. 그러나... -
Calcium Current and Background Current Activation in L-triiodothyronine Loaded Ventricular Myocytes of the Rabbit
Han, Jin, Kim, Eui-Yong, Han, Jae-Hee, Park, Choon-Ok, Hong, Seong-Geun, Leem, Chae-Hun, So, In-Suk, Ho, Won-Kyung, Earm, Yung-E, Sung, H 대한생리학회 대한생리학회지 14 Pages
대한생리학회 대한생리학회지 1992, 제 26권 제 2호 1 99-112 (14 pages)
Permissive action of thyroid hormone at the level of Ca channel and responsible mechanisms underlying thyroid hormone-induced change in myocardial contractile state and T3-induced arrhythmias were investigated in rabbit ventricular or atrial myocytes using whole cell patch clamp technique. Single cells were isolated by Langendorff perfusion with collagenase. Cardiac myocytes were incubated in low-Cl-,, high-K+ medium containing 1μM L-triiodothyronine (T3) at 4℃ for 2.10 hours. The calcium... -
Virus Incidence of Sweet Potato in Korea from 2011 to 2014
한국식물병리학회 The Plant Pathology Journal 11 Pages
한국식물병리학회 The Plant Pathology Journal 2017, 33권 5호 4 467-477 (11 pages)
A nationwide survey was performed to investigate the current incidence of viral diseases in Korean sweet potatoes for germplasm and growing fields from 2011 to 2014. A total of 83.8% of the germplasm in Korea was infected with viruses in 2011. Commercial cultivars that were used to supply growing fields were infected at a rate of 62.1% in 2012. Among surveyed viruses, the incidence of five Potyvirus species that infect sweet potato decreased between 2012 and 2013, and then... -
Challenges of the postmodern ‘Learning Society’ A critical approach
Peter Alheit 한국성인교육학회 한국성인교육학회 학술대회지 21 Pages
한국성인교육학회 한국성인교육학회 학술대회지 2005년호 7 85-105 (21 pages)
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Early Childhood Education and Care Policy in Australia: An Insight into Parent Perceptions Posted Online
Susanne Garvis, Donna Pendergast, Harry Kanasa 환태평양유아교육연구학회 Asia-Pacific journal of research in early childhood education 17 Pages
환태평양유아교육연구학회 Asia-Pacific journal of research in early childhood education 2013, Vol.7 No.3 5 103-119 (17 pages)
Recently in Australia there has been a shift towards the increased use of formal early childhood education and care services. Federal, state and territory policy makers have responded with reform agendas designed to improve the quality of early childhood education and care. There are few studies that provide insights into community perceptions of current initiatives in early childhood education policy and their perceived effectiveness with families. This study begins to address this void by... -
Characteristics and Fate of Stormwater Runoff Pollutants in Constructed Wetlands
Jawara Christian Alihan, Marla Maniquiz-Redillas, Jiyeon Choi, Precious Eureka Flores, Lee-Hyung Kim 한국습지학회 한국습지학회지 8 Pages
한국습지학회 한국습지학회지 2017, Vol.19 No.1 4 37-44 (8 pages)
Nonpoint source (NPS) pollution continues to degrade the water quality. NPS pollutants signals high concerns against a sustainable environment. Low impact development (LID) is the leading management practice which regulates and treats stormwater runoff especially in highly impervious urban areas. Constructed wetlands are known to have efficient removal capability of NPS pollutants. Likewise, these LID facilities were intended to maintain the predeveloped hydrologic regime through series of...
