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141.

Opening of ATP-sensitive K+ Channel by Pinacidil Requires Serine/ Threonine Phosphorylation in Rat Ventricular Myocytes

Yong-GeunKwakSoo-WanChae 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 11 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1999, Vol.3 No.3 7 293-303 (11 pages)

Yong-GeunKwakSoo-WanChae 저
...
- 4,000원
The influences of specific protein phosphatase and protein kinase inhibitors on the ATP-sensitive K⁢ (KATP) channel-opening effect of pinacidil were investigated in single rat ventricular myocytes using patch clamp technique. In cell-attached patches, pinacidil (100 μM) induced the opening of the KATP channel, which was blocked by the pretreatment with H-7 (100 μM) whereas enhanced by the pretreatment with genistein (30 μM) or tyrphostin A23 (10 μM). In inside-out patches, pinacidil...
142.

Gradual Reperfusion Lowers the Incidence of Reperfusion-Induced Ventricular Fibrillation in a Cat Model of Regional Ischemia

You-HoKim, HeungSikNa, HyunJungNam, Gyu-YoungHur, Seung-WhanLee, SungSookPark, SeungKilHong 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1999, Vol.3 No.1 6 47-52 (6 pages)

You-HoKim, HeungSikNa, HyunJungNam, Gyu-YoungHur, Seung-WhanLee, SungSookPark, SeungKilHong 저
...
- 3,000원
Blood flow restoration to ischemic zone of the heart is essential to salvage of ischemic tissue. However, there is a large body of evidence documenting that the reperfusion can induce reperfusion injury like reperfusion-induced malignant arrhythmias. In the present study, employing a cat model of regional cardiac ischemia, we examined if reperfusion rendered in a gradual fashion could lower the incidence of reperfusion-induced ventricular fibrillation (VF), which usually precipitated within a...
143.

Dopaminergic Inhibition of Dorsal Horn Cell Activity in the Cat

KyungChulKim, HongKeeShin, KeeSoonKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 10 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1998, Vol.2 No.6 2 661-670 (10 pages)

KyungChulKim, HongKeeShin, KeeSoonKim 저
...
- 3,000원
in behavioral pain test, such as tail flick and hot plate test, but there appears to be a great variance in the reports on the antinociceptive effect of dopamine depending on the dosage and route of drug administration and type of animal preparation. In the present study, the effects of dopamine on the responses of wide dynamic range (WDR) cells to mechanical, thermal and graded electrical stimuli were investigated, and the dopamine-induced changes in WDR cell responses were compared between...
144.

Effects of Prostaglandin E2 on the Spontaneous Contractions and Electrical Activities of the Antral Circular Muscle in Guinea-pig Stomach

JongYoonKim, SungJoonKim, TongMookKang, SangJinLee, JaeYeoulJun, InsukSo, KiWhanKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1998, Vol.2 No.3 11 361-368 (8 pages)

JongYoonKim, SungJoonKim, TongMookKang, SangJinLee, JaeYeoulJun, InsukSo, KiWhanKim 저
...
- 3,000원
The spontaneous contractions of gastric smooth muscles are regulated by slow waves, which are modulated by both nervous system and humoral agents. This study was designed to examine the effects of prostaglandin E2 (PGE2) on the contractile and electrical activities of antral smooth muscles in guinea-pig stomach, using an intracellular recording technique. To elucidate the underlying mechanism for its effect on contractility, ionic currents were also measured using a whole-cell patch clamp...
145.

Nitric Oxide Impairs the Recovery from Hemorrhagic Hypotension in Conscious Rats

Yoon-yubParkYoung-ManLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1998, Vol.2 No.3 9 345-351 (7 pages)

Yoon-yubParkYoung-ManLee 저
...
- 3,000원
The role of nitric oxide (NO) in the hemorrhagic hypotension was examined using a NO synthase inhibitor, Nω-nitro-L-arginine methyl ester (L-NAME), in conscious rats. The rats were bled at a constant rate (2 ml/kg/min) through a femoral arterial catheter until the mean arterial pressure (MAP) was reduced by 50 mmHg. We studied the responses to hemorrhage under normal condition (Control) and after the pretreatment with 3 doses of L-NAME (1.6, 8, 40 mg/kg i.v. of NOX1.6, NOX8, and NOX40,...
146.

Effects of Histamine H2-Receptor Stimulation on Mg2+ Efflux in Perfused Guinea Pig Heart

Hyung-SubKang, Sung-EunChang, Chang-WonKang, Soo-WanChae, Jin-SangKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1998, Vol.2 No.1 6 49-54 (6 pages)

Hyung-SubKang, Sung-EunChang, Chang-WonKang, Soo-WanChae, Jin-SangKim 저
...
- 3,000원
147.

Sensory Inputs to Upper Cervical Spinal Neurons Projecting to Midbrain in Cats

JongHoKim, Han-SeongJeong, Jong-SeongPark, Jong-KeunKim, Sah-HoonPark 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 11 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1998, Vol.2 No.1 2 9-19 (11 pages)

JongHoKim, Han-SeongJeong, Jong-SeongPark, Jong-KeunKim, Sah-HoonPark 저
...
- 4,000원
148.

쥐 척수후각세포의 유해자극 반응에 대한 칼슘이온통로 차단제의 억제작용 Calcium Channel Blockers Suppress the Responses of Rat Dorsal Horn Cell to Nociceptive Input

신홍기, 강석한, 김기순, HongKeeShin, SokHanKang, KeeSoonKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 13 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1997, Vol.1 No.6 3 625-637 (13 pages)

신홍기, 강석한, 김기순, HongKeeShin, SokHanKang, KeeSoonKim 저
...
- 4,200원
Calcium ions are implicated in a variety of physiological functions, including enzyme activity, membrane excitability, neurotransmitter release, and synaptic transmission, etc. Calcium antagonists have been known to be effective for the treatment of exertional angina and essential hypertension. Selective and nonselective voltage-dependent calcium channel blockers also have inhibitory action on the acute and tonic pain behaviors resulting from thermal stimulation, subcutaneous formalin injection...
149.

Changes of Renal Peripheral Benzodiazepine Receptor in the Stress/ Anxiety Response

Jeoung-HeeHa, Kwang-HunLee, Seung-DoukCheung, Hyung-BaePark, Maan-GeeLee, Hyoung-ChulChoi, Uy-DongSohn, Kwang-YounLee, Won-JoonKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1997, Vol.1 No.5 7 523-528 (6 pages)

Jeoung-HeeHa, Kwang-HunLee, Seung-DoukCheung, Hyung-BaePark, Maan-GeeLee, Hyoung-ChulChoi, Uy-DongSohn, Kwang-YounLee, Won-JoonKim 저
...
- 3,000원
Peripheral benzodiazepine receptor(PBR) has been indentified in various peripheral tissues including kidney. The physiological and pharmacological functions of PBR are still uncertain, althought it has been suggested that these are associated with the regulation of stress/anxiety response. Diazepam progeny, which were exposed to diazepam perinatally, was reported to be an animal model of chronic anxiety. However, PBR in the diazepam progenies are not known yet. In the present study, therefore,...
150.

Clozapine이 백서의 억제된 자발적 교대 행동에 미치는 영향

천강훈, 이기철, 이정호, 최영민 전성일, 정홍경, 류정환, 최미 대한신경정신의학회 신경정신의학 9 Pages

대한신경정신의학회 신경정신의학 1998, 제 37권 제 5호 21 983-991 (9 pages)

천강훈, 이기철, 이정호, 최영민 전성일, 정홍경, 류정환, 최미 저
...
- 3,000원
연구목적： 강박장애의 생물학적 원인론중 세로토닌-도파민 상호작용 가설에 적합한 5-HT2 수용체와 도파민 D2 수 용체를 동시에 차단하는 약물의 일종인 cloazpine과 세로토닌 재흡수 차단약물인 clomipramine, 그리고 도 파민 D2 수용체 차단 약물인 haloperidol을 실험백서의 강박장애 동물모형에 투여하고 자발적 교대 행동에 미치는 영향을 비교, 측정하였다. 그 결과로서 1) 세로토닌 수용체와 도파민 수용체를 동시에 차단하는 약물의 효과를 확인하고, 2) 세로토닌 과 도파민 수용체 동시차단 약물의 효과가 확인되면 임상적으로...

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