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151.

Increased Expression of ATP-sensitive K＋ Channels Improves the Right Ventricular Tolerance to Hypoxia in Rabbit Hearts

SeongWooChoi, JunSeokAhn, HyoungKyuKim, NariKim, Tae-HoonChoi, Sung-WooPark, EnAKo, WonSunPark, Dae-KyuSong, JinHan 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2011, Vol.15 No.4 1 189-194 (6 pages)

SeongWooChoi, JunSeokAhn, HyoungKyuKim, NariKim, Tae-HoonChoi, Sung-WooPark, EnAKo, WonSunPark, Dae-KyuSong, JinHan 저
...
- 3,000원
ATP-sensitive K＋ channels (KATP) are major component of preventing ischemia-reperfusion injury. However, there is little information regarding to the expressional difference of KATP and its function between left and right ventricles. In this study, we measured the lactate dehydrogenase release of rabbit heart slices in vitro and determined the difference of the KATP expression at the both ventricles by measuring the level of KATP-forming Kir6.2 (OcKir6.2) mRNA using in situ hybridization. The...
152.

Ser1778 of 53BP1 Plays a Role in DNA Double-strand Break Repairs

Jung-HeeLee, Hyang-MinCheong, Mi-YoungKang, Sang-YoungKim, YoonsungKang 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2009, Vol.13 No.5 2 343-348 (6 pages)

Jung-HeeLee, Hyang-MinCheong, Mi-YoungKang, Sang-YoungKim, YoonsungKang 저
...
- 3,000원
53BP1 is an important genome stability regulator, which protects cells against double-strand breaks. Following DNA damage, 53BP1 is rapidly recruited to sites of DNA breakage, along with other DNA damage response proteins, including Ճ-H2AX, MDC1, and BRCA1. The recruitment of 53BP1 requires a tandem Tudor fold which associates with methylated histones H3 and H4. It has already been determined that the majority of DNA damage response proteins are phosphorylated by ATM and/or ATR after DNA...
153.

Estrogen Pretreatment of Organotypic Hippocampal Slices Protects Neurons against Oxygen-Glucose Deprivation with Akt Activation

Eun-MiPark, SunghuiHong, Kyung-EunLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2006, Vol.10 No.3 2 123-130 (8 pages)

Eun-MiPark, SunghuiHong, Kyung-EunLee 저
...
- 3,000원
In several experimental models, estrogens protect neurons against ischemic insults. However, the recent clinical studies of hormone replacement showed negative results to prevent stroke. Therefore, optimal models to study estrogen replacement for neuroprotection are needed before its clinical application. Organotypic hippocampal slice under oxygen-glucose deprivation (OGD) has been established as a model of cerebral ischemia and has advantages to study drug effects. We investigated whether...
154.

Modulation of Large Conductance Ca2+-activated K+ Channel of Skin Fibroblast (CRL-1474) by Cyclic Nucleotides

JihyunYun, SeungtaeKim, HyoweonBang 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 4 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2005, Vol.9 No.2 9 131-134 (4 pages)

JihyunYun, SeungtaeKim, HyoweonBang 저
...
- 1,500원
Potassium channels in human skin fibroblast have been studied as a possible site of Alzheimer disease pathogenesis. Fibroblasts in Alzheimer disease show alterations in signal transduction pathway such as changes in Ca2⁢ homeostasis and/or Ca2⁢-activated kinases, phosphatidylinositol cascade, protein kinase C activity, cAMP levels and absence of specific K⁢ channel. However, little is known so far about electrophysiological and pharmacological characteristics of...
155.

Heterogeneity of the SR-dependent Inward Na+-Ca2+ Exchange Current in the Heavily Ca2+-buffered Rat Ventricular Myocytes

Kyung-BongYoon, Sung-WanAhn, ChangMannKo 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 10 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2004, Vol.8 No.2 6 101-110 (10 pages)

Kyung-BongYoon, Sung-WanAhn, ChangMannKo 저
...
- 3,000원
Voltage-sensitive release mechanism was pharmacologically dissected from the Ca2⁢-induced Ca2⁢ release in the SR Ca2⁢ release in the rat ventricular myocytes patch-clamped in a whole-cell mode. SR Ca2⁢ release process was monitored by using forward-mode Na⁢-Ca2⁢ exchange after restriction of the interactions between Ca2⁢ from SR and Na⁢-Ca2⁢ exchange within micro-domains with heavy cytosolic Ca2⁢ buffering with 10 mM BAPTA. During...
156.

Role of Stretch-Activated Channels in Stretch-Induced Changes of Electrical Activity

JaeBoumYoum, Su-HyunJo, ChaeHunLeem, Won-KyungHo, YungE. 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2004, Vol.8 No.1 6 33-41 (9 pages)

JaeBoumYoum, Su-HyunJo, ChaeHunLeem, Won-KyungHo, YungE. 저
...
- 3,000원
We developed a cardiac cell model to explain the phenomenon of mechano-electric feedback (MEF), based on the experimental data with rat atrial myocytes. It incorporated the activity of ion channels, pumps, exchangers, and changes of intracellular ion concentration. Changes in membrane excitability and Ca2⁢ transients could then be calculated. In the model, the major ion channels responsible for the stretch-induced changes in electrical activity were the stretch-activated channels (SACs)....
157.

Antagonists of NMDA Receptor, Calcium Channel and Protein Kinase C Potentiate Inhibitory Action of Morphine on Responses of Rat Dorsal Horn Neuron

HongKeeShin, YeonSukKim, JongHunJun, SeoEunLee, JaeHwaKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 4 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2003, Vol.7 No.5 1 251-254 (4 pages)

HongKeeShin, YeonSukKim, JongHunJun, SeoEunLee, JaeHwaKim 저
...
- 1,500원
The present study was designed to examine whether the co-application of morphine with Ca2⁢ channel antagonist (Mn2⁢, verapamil), N-methyl-D-aspartate (NMDA) receptor antagonist (2-amino-5-phosphonopentanoic acid[AP5], Mg2⁢) or protein kinase C inhibitor (H-7) causes the potentiation of morphine- induced antinociceptive action by using an in vivo electrophysiological technique. A single iontophoretic application of morphine or an antagonist alone induced weak inhibition of wide...
158.

Involvement of NMDA Receptor and L-type Calcium Channel in the Excitatory Action of Morphine

BonSeopKoo, HongKeeShin, SukHanKang, JongHunJun 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2002, Vol.6 No.5 2 241-246 (6 pages)

BonSeopKoo, HongKeeShin, SukHanKang, JongHunJun 저
...
- 3,000원
We studied the excitatory action of morphine on the responses of dorsal horn neuron to iontophoretic application of excitatory amino acid and C-fiber stimulation by using the in vivo electrophysiological technique in the rat. In 137 of the 232 wide dynamic range (WDR) neurons tested, iontophoretic application of morphine enhanced the WDR neuron responses to N-methyl-D-aspartate (NMDA), kainate, and graded electrical stimulation of C-fibers. Morphine did not have any excitatory effects on the...
159.

Comparison of the Determinants in the Differences in Force- Frequency Relationships between Rat and Rabbit Left Atria

ChangMannKoSoon-JinKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2000, Vol.4 No.5 11 417-425 (9 pages)

ChangMannKoSoon-JinKim 저
...
- 3,000원
in the roles of Na⁢/Ca2⁢ exchanger and sarcoplasmic reticulum (SR), which are major intracellular Ca2⁢ regulatory mechanisms in the heart, were examined in the amplitude accommodation to the frequency that changed from 3 Hz to the variable test frequencies for 5 minutes in the electrically field stimulated left atria (LA) of rat and rabbit. Norepinephrine strongly increased the frequency-related amplitude accommodation in both of rat and rabbit LA, while monensin, oubain or the...
160.

Effects of Cholecystokinin Octapeptide on Neuronal Activities in the Rat Nucleus Tractus Solitarius

HyewhonRhim, Chan-WoongPark 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2000, Vol.4 No.4 2 275-281 (7 pages)

HyewhonRhim, Chan-WoongPark 저
...
- 3,000원
is a gastrointestinal hormone which plays an important role in satiety and gastric motility. It is also widely distributed throughout the central nervous system, where it appears to be involved in the central control of anxiety, feeding behavior and nociception. Two distinct CCK receptor types, CCKA and CCKB, have been found in the brain. Both CCK receptors coexist in the rat nucleus tractus solitarius (NTS), which is the primary center for the coordination of peripheral and central activities...

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