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Effects of Lemakalim, a Potassium Channel Opener, on the Contractility and Electrical Activity of the Antral Circular Muscle in Guinea-Pig Stomach
Kim, Sung-Joon, Jun, Jae-Yeoul, Choi, Youn-Baik, Kim, Ki-Whan, Kim, Woo-Gyeum 대한생리학회 대한생리학회지 14 Pages
대한생리학회 대한생리학회지 1994, 제 28권 제 1호 4 37-50 (14 pages)
Synthetic potassium channel openers (KCOs) are agents capable of opening K-channels in excitable cells. These agents are known to have their maximal potency in the smooth muscle tissue, especially in the vascular smooth muscle. Much attention has been focused on the type of K-channel that is responsible for mediating the effects of KCOs. As the KCO-induced changes are antagonized by glibenclamide, an KATP (ATP-sensitive K-channel) blocker in the pancreatic β-cell, KATP was suggested to be the... -
Motor Areas of the Cerebral Cortex-New Vistas
Tanji, Jun 대한생리학회 대한생리학회지 8 Pages
대한생리학회 대한생리학회지 1994, 제 28권 제 1호 2 19-26 (8 pages)
On the basis of morphological and functional studies, it is now established that there exist multiple motor representation areas in the frontal lobe of subhuman primates. Recent development of analysis on cerebral critical organization in human subjects, utilizing novel techniques of PET and MRI, provides evidence of corresponding motor areas. Each area has its unique sources of inputs from the thalamus and from other parts of the cerebral cortex. To understand functional roles of these... -
Cardiovascular Neurons Mediating Somatosympathetic Reflex in Rostral Ventrolateral Medulla
Goo, Yong-Sook, Kim, Sang-Jeong, Kim, Jun, Sung, Ho-Kyung 대한생리학회 대한생리학회지 14 Pages
대한생리학회 대한생리학회지 1993, 제 27권 제 2호 7 185-198 (14 pages)
The rostral ventrolateral medulla (RVLM) includes vasopressor neurons, which transmit activation signals to the intermediolateral nucleus (IML) of the spinal cord, where the preganglionic sympathetic nucleus is located, to raise arterial blood pressure (BP). However, controversy exists as to the possible depressor area in the RVLM and the pathway involved. The present study persued evidence far the location of depressor neurons and the pathway by simultaneously observing changes in BP and the... -
Regulatory Action of ß-adrenergic Agonist and 8-bromocyclic AMP on Calcium Currents in the Unfertilized Mouse Eggs
Haan, Jae-Hee, Cheong, Seung-Jin, Kim, Yang-Mi, Park, Choon-Ok, Hong, Seong-Geun 대한생리학회 대한생리학회지 10 Pages
대한생리학회 대한생리학회지 1993, 제 27권 제 2호 6 175-184 (10 pages)
There are many report suggesting that influx and intracellular calcium concentration ([Ca2+]i) are related to cell signalling in various cells. However, it has not been reported that calcium channel activation is affected by the substances involved in signal transduction pathways in the mouse eggs. In this study, the effects of isoprenaline (ISP) and cyclic AMP on calcium influx through calcium channels were investigated to show their relationship with the signal transduction process in... -
Effects of Noradrenaline on the Spontaneous Contraction and Ionic Current in the Antral Circular Muscle of Guinea-pig Stomach
Jun, Jae-Yeoul, Lee, Sang-Jin, Kim, Sung-Joon, Suh, Jae-Yul, So, In-Suk, Hwang, Sang-Ik, Kim, Ki-Whan 대한생리학회 대한생리학회지 8 Pages
대한생리학회 대한생리학회지 1993, 제 27권 제 2호 1 115-122 (8 pages)
There is evidence that noradrenaline enhances spontaneous contractions dose-dependently in guinea-pig antral circular muscle. To investigate the mechanism of this excitatory action, slow waves and membrane currents were recorded using conventional microelectrode techniques in muscle strips and the whole cell patch clamp technique in isolated gastric myocytes. On recording slow waves, noradrenaline (10-5 M) induced the hyperpolarization of the membrane potential, although the shape of the slow... -
Voltage-Dependent Ionic Currents and Their Regulation by GTP and Phorbol Ester in the Unfertilized Eggs of Mouse and Hamster
Kim, Ik-Hyun, Kim, Yang-Mi, Haan, Jae-Hee, Park, Choon-Ok, Hong, Seong-Geun 대한생리학회 대한생리학회지 14 Pages
대한생리학회 대한생리학회지 1993, 제 27권 제 1호 9 93-106 (14 pages)
The present study was performed to investigate the properties of ionic currents elicited by voltage pulses in the unfertilized eggs of mouse and hamster by using the whole cell voltage clamp techniques and to find out if there are any differences in properties between eggs of the two rodents. In addition, the modulatory effect of G proteins and protein kinase C (PKC) on the ionic channels were observed. The inward current in hamster eggs was shown to be due to Ca2+ current (ica)). The current... -
Effects of the Endothelium on the Contractile Responses to Norepinephrine in Isolated Proximal and Distal Coronary Artery of Pigs
Kim, Jong-Hoon, Jeon, Byeong-Hwa, Chang, Seok-Jong, Park, Hae-Kun 대한생리학회 대한생리학회지 10 Pages
대한생리학회 대한생리학회지 1993, 제 27권 제 1호 3 27-36 (10 pages)
Effects of the endothelium on the contractile responses to norepinephrine (NE) were investigated in isolated helical strips of the proximal and distal coronaries artery of pigs. The helical strips were immersed in Tris-buffered Tyrode s solution equilibrated with 100% O2 at 35℃ and its isometric tension was measured. NE relaxed the strips precontracted with acetylcholine from both the proximal and distal coronary artery. NE-induced relaxation, which might be induced mainly by β-adrenoceptor... -
Effect of Capsaicin on Causalgiform Pain in the Rat
Kim, Kwang-Jin, Jeon, Byeong-Hwa, Kim, Won-Sik, Park, Kyung-Ran, Choi, Sae-Jin 대한생리학회 대한생리학회지 8 Pages
대한생리학회 대한생리학회지 1992, 제 26권 제 2호 6 143-150 (8 pages)
The purpose of this study is to obtain the effective concentration of capsaicin to relieve pain with no change in the number of C-fibers and its effective duration for pain relief. Capsaicin has been used extremely as a experimental tool and as topical medications for acute or chronic tissue injuries and partial nerve injury is the main cause of causalgiform pain disorders in humans. Here, the left sciatic nerve was ligated unilaterally at the high level of the thigh to prepare an animal model... -
Cl--sensitive Component of Ca2+-activated Tail Current in Rabbit Atrial Myocytes
Park, Choon-Ok, So, In-Suk, Ho, Won-Kyung, Kim, Woo-Gyeum, Earm, Yung-E 대한생리학회 대한생리학회지 10 Pages
대한생리학회 대한생리학회지 1992, 제 26권 제 1호 3 27-36 (10 pages)
We used the whole cell patch clamp technique to examine the ionic basis for the tail current after depolarizing pulse in single atrial myocytes of the rabbit. We recorded the tail currents during various repolarizations after short depolarizing pulse from a holding potential of -70 mV. The potassium currents were blocked by external 4-aminopyridine and replacement of internal potassium with cesium. The current was reversed to the outward direction above +10 mV. High concentrations of...


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