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1681.

Expression Profile of Neuro-Endocrine-Immune Network in Rats with Vascular Endothelial Dysfunction

LujinLi, ZhenghuaJia, LingXu, YilingWu, QingshanZheng 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2014, Vol.18 No.2 13 177-182 (6 pages)

LujinLi, ZhenghuaJia, LingXu, YilingWu, QingshanZheng 저
...
- 3,000원
This study was to determine the correlation between endothelial function and neuro-endocrine- immune (NEI) network through observing the changes of NEI network under the different endothelial dysfunction models. Three endothelial dysfunction models were established in male Wistar rats after exposure to homocysteine (Hcy), high fat diet (HFD) and Hcy+HFD. The results showed that there was endothelial dysfunction in all three models with varying degrees. However, the expression of NEI network was...
1682.

Decreasing Effect of LidocaineㆍHCl on the Thickness of the Neuronal and Model Membrane

Sung-MinPark, Jong-SunPark, Jae-HanKim, Jin-HyunBaek, Tae-GyunYoon, Do-KeunLee, Won-HyangRyu, In-KyoChung, UyDongSohn, Hye-OckJang, IlYun 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 5 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2013, Vol.17 No.4 1 253-257 (5 pages)

Sung-MinPark, Jong-SunPark, Jae-HanKim, Jin-HyunBaek, Tae-GyunYoon, Do-KeunLee, Won-HyangRyu, In-KyoChung, UyDongSohn, Hye-OckJang, IlYun 저
...
- 1,500원
This study examined the mechanism of action of a local anesthetic, lidocaineㆍHCl. Energy transfer between the surface fluorescent probe, 1-anilinonaphthalene-8-sulfonic acid, and the hydrophobic fluorescent probe, 1,3-di(1-pyrenyl) propane, was used to determine the effect of lidocaineㆍHCl on the thickness (D) of the synaptosomal plasma membrane vesicles (SPMV) isolated from the bovine cerebral cortex, and liposomes of the total lipids (SPMVTL) and phospholipids (SPMVPL) extracted from the...
1683.

Inhibitory Effects of Quercetin on Muscle-type of Nicotinic Acetylcholine Receptor-Mediated Ion Currents Expressed in Xenopus Oocytes

Byung-HwanLee, Tae-JoonShin, Sung-HeeHwang, Sun-HyeChoi, JiyeonKang, Hyeon-JoongKim, Chan-WooPark, Soo-HanLee, Seung-YeolNah 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2011, Vol.15 No.4 2 195-201 (7 pages)

Byung-HwanLee, Tae-JoonShin, Sung-HeeHwang, Sun-HyeChoi, JiyeonKang, Hyeon-JoongKim, Chan-WooPark, Soo-HanLee, Seung-YeolNah 저
...
- 3,000원
The flavonoid quercetin is a low molecular weight compound generally found in apple, gingko, tomato, onion and other red-colored fruits and vegetables. Like other flavonoids, quercetin has diverse pharmacological actions. However, relatively little is known about the influence of quercetin effects in the regulation of ligand-gated ion channels. Previously, we reported that quercetin regulates subsets of nicotinic acetylcholine receptors such as Ձ3Ղ4, Ձ7 and Ձ9Ձ10....
1684.

Calcium Sensitization Induced by Sodium Fluoride in Permeabilized Rat Mesenteric Arteries

EnyueYang, JoonYongCho, UyDongSohn, InKyeomKim, 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2010, Vol.14 No.1 8 51-57 (7 pages)

EnyueYang, JoonYongCho, UyDongSohn, InKyeomKim, 저
...
- 3,000원
It was hypothesized that NaF induces calcium sensitization in Ca2＋-controlled solution in permeabilized rat mesenteric arteries. Rat mesenteric arteries were permeabilized with Ղ- escin and subjected to tension measurement. NaF potentiated the concentration-response curves to Ca2＋ (decreased EC50 and increased Emax). Cumulative addition of NaF (4.0, 8.0 and 16 mM) also increased vascular tension in Ca2＋-controlled solution at pCa 7.0 or pCa 6.5, but not at pCa 8.0. NaF-induced...
1685.

Flavone Attenuates Vascular Contractions by Inhibiting RhoA/Rho Kinase Pathway

InjiBaek, SuBunJeon, Min-JiSong, EnyueYang, UyDongSohn, InKyeomKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2009, Vol.13 No.3 10 201-207 (7 pages)

InjiBaek, SuBunJeon, Min-JiSong, EnyueYang, UyDongSohn, InKyeomKim 저
...
- 3,000원
Our previous study demonstrated that flavone inhibits vascular contractions by decreasing the phosphorylation levelof the myosin phosphatase target subunit (MYPT1). In the present study, we hypothesized that flavone attenuates vascular contractions through the inhibition of the RhoA/Rho kinase pathway. Rat aortic rings were denuded of endothelium, mounted in organ baths, and contracted with either 30 nM U46619 (a thromboxane A2 analogue) or 8.0 mM NaF 30 min after pretreatment with either...
1686.

PKC-Independent Stimulation of Cardiac Na+/Ca2+ Exchanger by Staurosporine

TongMookKang 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2008, Vol.12 No.5 7 259-266 (8 pages)

TongMookKang 저
...
- 3,000원
[Ca2+]i transients by reverse mode of cardiac Na+/Ca2+ exchanger (NCX1) were recorded in fura-2 loaded BHK cells with stable expression of NCX1. Repeated stimulation of reverse NCX1 produced a long-lasting decrease of Ca2+ transients ('rundown'). Rundown of NCX1 was independent of membrane PIP2 depletion. Although the activation of protein kinase C (PKC) was observed during the Ca2+ transients, neither a selective PKC inhibitor (calphostin C) nor a PKC activator (PMA) changed the degrees of...
1687.

Multiple 5-Hydroxytryptamine (5-HT) Receptors Are Involved in the Melittin-induced Nociceptive Responses in Rat I. Role of Peripheral 5-HT Receptor

HongKeeShin, SeoEunLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2007, Vol.11 No.5 9 221-226 (6 pages)

HongKeeShin, SeoEunLee 저
...
- 3,000원
Melittin-induced tonic pain model is characterized by local inflammation, edema, spontaneous flinchings, and sustained mechanical hypersensitivity. These nociceptive responses are mediated through selective activation of capsaicin-sensitive primary afferent fibers by melittin. The present study was undertaken to elucidate the role of peripheral 5-hydroxytryptamine (5-HT) receptors in the melittin-induced nociceptive responses. Changes in mechanical threshold, flinching behaviors and paw...
1688.

Ca2+-dependent Long-term Inactivation of Cardiac Na+/Ca2+ Exchanger

Jee-EunLee, TongMookKang 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2007, Vol.11 No.5 4 183-188 (6 pages)

Jee-EunLee, TongMookKang 저
...
- 3,000원
Using BHK cells with stable expression of cardiac Na+/Ca2+ exchanger (BHK-NCX1), reverse mode (i.e. Ca2+ influx mode) of NCX1 current was recorded by whole-cell patch clamp. Repeated stimulation of reverse NCX1 produced a cytosolic Ca2+-dependent long-term inactivation of the exchanger activity. The degrees of inactivation correlated with NCX1 densities of the cells and were attenuated by reduced Ca2+ influx via the reverse exchanger. The inactivation of NCX1 was attenuated by (i) inhibition of...
1689.

NMDA Receptor-dependent Inhibition of Synaptic Transmission by Acute Ethanol Treatment in Rat Corticostriatal Slices

SeJoonChoi, KiJungKim, HyeongSeokCho, SeongYunKim, Dong-SeokYim, Young-JinCho, SangJuneHahn, Ki-WugSung 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2006, Vol.10 No.6 2 303-308 (6 pages)

SeJoonChoi, KiJungKim, HyeongSeokCho, SeongYunKim, Dong-SeokYim, Young-JinCho, SangJuneHahn, Ki-WugSung 저
...
- 3,000원
The effects of ethanol on corticostriatal synaptic transmission were examined, using extracellular recording and analysis of population spike amplitudes in rat brain slices, to study how acute ethanol intoxication impairs striatal function. Ethanol caused a decrease in population spike amplitudes in a dose dependent manner (50∼200 mM). Pretreatment with picrotoxin, a γ-amino butyric acid (GABA)A receptor antagonist, increased the population spikes but ethanol (100 mM) was still effective in...
1690.

Effects of Phosphodiesterase 5 Inhibition with Sildenafil on Atrial Contractile and Secretory Function

HeXiuQuan, SunYoungKim, XuanShunJin, JongKwanPark, SungZooKim, KyungWooCho 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2006, Vol.10 No.3 6 149-154 (6 pages)

HeXiuQuan, SunYoungKim, XuanShunJin, JongKwanPark, SungZooKim, KyungWooCho 저
...
- 3,000원
Selective inhibition of phosphodiesterase (PDE) 5 opened a new therapeutic approach for cardiovascular disorders. Therefore, the effect of PDE5 inhibition on the cardiac function should thoroughly be defined. The purpose of the present study was to define the effects of sildenafil, a selective inhibitor of PDE5, on the atrial cGMP efflux, atrial dynamics, and the release of atrial natriuretic peptide (ANP). By perfusing rabbit left atria to allow atrial pacing, changes in atrial stroke volume...

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