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161.

Role of Caveolin-1 in Indomethacin-induced Death of Human Hepatoadenocarcinoma SK-Hep1 Cells

Kyung-NamKim, Ju-HeeKang, Sung-VinYim, Chang-ShinPark 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2008, Vol.12 No.4 3 143-148 (6 pages)

Kyung-NamKim, Ju-HeeKang, Sung-VinYim, Chang-ShinPark 저
...
- 3,000원
of control-siRNA-transfected cells. Furthermore, the viability of cells pretreated with CAV1 siRNA was markedly decreased by treatment with indomethacin (400ՌM for 24 h). However, the protein and mRNA levels of MDR1 were unchanged in CAV1-siRNA-transfected cells. These results suggest that CAV1 plays an important role as a major survival enzyme in cancer cells, and indomethacin can sensitively induce cell death under conditions of reduced CAV1 expression, independent of MDR1 expression.
162.

Characterization of Ionic Currents in Human Neural Stem Cells

ChaeGilLim, Sung-SooKim, HaeyoungSuh-Kim, Young-DonLee, SeungCheolAhn 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2008, Vol.12 No.4 1 131-136 (6 pages)

ChaeGilLim, Sung-SooKim, HaeyoungSuh-Kim, Young-DonLee, SeungCheolAhn 저
...
- 3,000원
The profile of membrane currents was investigated in differentiated neuronal cells derived from human neural stem cells (hNSCs) that were obtained from aborted fetal cortex. Whole-cell voltage clamp recording revealed at least 4 different currents: a tetrodotoxin (TTX)-sensitive Na+ current, a hyperpolarization-activated inward current, and A-type and delayed rectifier-type K+ outward currents. Both types of K+ outward currents were blocked by either 5 mM tetraethylammonium (TEA) or 5 mM...
163.

(? )-Epigallocatechin Gallate Inhibits the Pacemaker Activity of Interstitial Cells of Cajal of Mouse Small Intestine

KweonYoungKim, SooJinChoi, HyukJinJang, DongChuanZuo, PawanKumarShahi, ShankarPrasadParajuli, CheolHoYeum, PyungJinYoon, SeokChoi, JaeYeo 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2008, Vol.12 No.3 4 111-116 (6 pages)

KweonYoungKim, SooJinChoi, HyukJinJang, DongChuanZuo, PawanKumarShahi, ShankarPrasadParajuli, CheolHoYeum, PyungJinYoon, SeokChoi, JaeYeo 저
...
- 3,000원
The effects of (−)-epigallocatechin gallate (EGCG) on pacemaker activities of cultured interstitial cells of Cajal (ICC) from murine small intestine were investigated using whole-cell patch-clamp technique at 30oC and Ca2＋ image analysis. ICC generated spontaneous pacemaker currents at a holding potential of −70 mV. The treatment of ICC with EGCG resulted in a dose-dependent decrease in the frequency and amplitude of pacemaker currents. SQ-22536, an adenylate cyclase inhibitor, and...
164.

Neuroprotective Effects of Methanol Extracts of Jeju Native Plants on Hydrogen Peroxide-induced Cytotoxicity in SH-SY5Y Human Neuroblastoma Cells

Pil-JaeKong, Yu-MiKim, HeeJaeLee, Sung-SooKim, EunSookYoo, WanjooChun 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 5 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2007, Vol.11 No.5 2 170-174 (5 pages)

Pil-JaeKong, Yu-MiKim, HeeJaeLee, Sung-SooKim, EunSookYoo, WanjooChun 저
...
- 1,500원
Neuronal death is a common characteristic hallmark of a variety of neurodegenerative disorders including Alzheimer's disease and Parkinson's disease. However, there have been no effective drugs to successfully prevent neuronal death in those diseases, whereas oriental medicinal plants have to possess valuable therapeutic potentials to treat neurodegenerative diseases. In the present study, in an attempt to provide neuroprotective agents from natural plants, 80% methanol extracts of a wide range...
165.

Alternative Isoforms of TonEBP with Variable N-termini are Expressed in Mammalian Cells

HyoShinKim, SookJinSon, SeonNyoKim, YongDukKim, KwangJinKim, ByeongHwaJeon, JinBongPark, SangDoLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 4 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2007, Vol.11 No.3 9 135-138 (4 pages)

HyoShinKim, SookJinSon, SeonNyoKim, YongDukKim, KwangJinKim, ByeongHwaJeon, JinBongPark, SangDoLee 저
...
- 1,500원
In the present study, isoform-specific antibodies were produced to confirm the translation of the spliced mRNA to protein. TonEBP was immunoprecipitated by using anti-TonEBP antibody and then immunoblotted using anti-TonEBP or isoform specific antibodies to find out the expression profile of TonEBP isoforms in basal or stimulated condition. From these results, we conclude that all TonEBP isoforms are expressed in mammalian cells and their expression patterns are not same in every cells.
166.

A1 Receptor-mediated Protection against Amyloid Beta-induced Injury in Human Neuroglioma Cells

YongWoonCho, HyunJuJung, YongKeunKim, JaeSukWoo 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2007, Vol.11 No.2 1 37-43 (7 pages)

YongWoonCho, HyunJuJung, YongKeunKim, JaeSukWoo 저
...
- 3,000원
in neuroglial cells. The astrocyte-derived human neuroglioma cell line, A172 cells, and Aβ25∼35 were employed to produce an experimental Aβ-induced glial cell injury model. Adenosine significantly prevented Aβ-induced apoptotic cell death. Studies using various nucleotide receptor agonists and antagonists suggested that the protection was mediated by A1 receptors. Adenosine attenuated Aβ-induced impairment in mitochondrial functional integrity as estimated by cellular ATP level and MTT...
167.

Involvement of Caspases and Bcl-2 Family in Nitric Oxide-Induced Apoptosis of Rat PC12 Cells

Yeon-JinJeong, Ji-YeonJung, Jin-HaLee, Jin-HyoungCho, Guem-SugLee, Sun-HunKim, Won-JaeKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2006, Vol.10 No.6 6 329-336 (8 pages)

Yeon-JinJeong, Ji-YeonJung, Jin-HaLee, Jin-HyoungCho, Guem-SugLee, Sun-HunKim, Won-JaeKim 저
...
- 3,000원
the nitric oxide (NO)-induced cytotoxic mechanism in PC12 cells. Sodium nitroprusside (SNP), an NO donor, decreased the viability of PC12 cells in dose- and time- dependent manners. SNP enhanced the production of reactive oxygen species (ROS), and gave rise to apoptotic morphological changes including cell shrinkage, chromatin condensation, and DNA fragmentation. Expression of Bax was not affected, whereas Bcl-2 was downregulated in SNP-treated PC12 cells. SNP augmented the release of cytochrome...
168.

pH-mediated Regulation of Pacemaker Activity in Cultured Interstitial Cells of Cajal

ByungJooKim, JaeHwaLee, InsukSo, KiWhanKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2006, Vol.10 No.1 2 7-12 (6 pages)

ByungJooKim, JaeHwaLee, InsukSo, KiWhanKim 저
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- 3,000원
Interstitial cells of Cajal (ICCs) are pacemakers in gastrointestinal tracts, regulating rhythmicity by activating nonselective cation channels (NSCCs). In the present study, we investigated the general characteristics and pH-mediated regulation of pacemaker activity in cultured interstitial cells of Cajal. Under voltage clamp mode and at the holding potential of ⁣60 mV, the I-V relationships and difference current showed that there was no reversal potential and voltage-independent inward...
169.

Effect of Extracts from Safflower Seeds on Osteoblastic Differentiation and Intracellular Free Calcium Concentration in MC3T3-E1 Cells

Hye-OckJang, Hyun-SupEom, Sung-BaeRoh, IlYun 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2005, Vol.9 No.1 8 55-62 (8 pages)

Hye-OckJang, Hyun-SupEom, Sung-BaeRoh, IlYun 저
...
- 3,000원
fraction significantly increased the [Ca2⁢]i of the cultured osteoblast cells (8⁓104) to the extent that it deserves a considerable attention. Furthermore, the crude extract and aqueous fraction increased the [Ca2⁢]i of the cultured osteoblast cells, and 300μM Cd2⁢, specific calcium channel blocker, completely blocked the increase. Therefore, the increased [Ca2⁢]i of the cultured osteoblast cells by safflower seed component continued to activate calcium channel.
170.

Hyperthermia-induced Apoptosis is Independent upon DNA Strand Breaks in Human Lymphoid Cells

HwaJinJung, WonHyeKa, JeeNaHwang, YoungRokSeo 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2004, Vol.8 No.6 9 345-350 (6 pages)

HwaJinJung, WonHyeKa, JeeNaHwang, YoungRokSeo 저
...
- 3,000원
are responsible for this phenomenon. Using the highly sensitive comet assay for DNA damage detection, we were unable to demonstrate DNA breaks immediately after heat shock in Raji human lymphoid cells. It showed that DNA breaks were not necessary for hyperthermic apoptosis, since its activity is indicative of DNA lesions. Here, we present a suggestion that a protein(s) is the major target for heat shock apoptosis. We firstly found glycerol, which reportedly stabilizes protein structure, showed a...

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