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161.

Altered Secretory Pattern of Pancreatic Enzymes and Gastrointestinal Hormones in Streptozotocin-induced Diabetic Rats

Myung-JunKim, GyeongRyulRyu, Sae-YoungYi, DoSikMin, Duck-JooRhie, ShinHeeYoon, SangJuneHahn, Myung-SukKim, Yang-HyeokJo 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2002, Vol.6 No.6 6 311-317 (7 pages)

Myung-JunKim, GyeongRyulRyu, Sae-YoungYi, DoSikMin, Duck-JooRhie, ShinHeeYoon, SangJuneHahn, Myung-SukKim, Yang-HyeokJo 저
...
- 3,000원
This study was performed to investigate the pancreatic exocrine dysfunction in streptozotocin- induced diabetic rats. Changes in pancreatic enzymes secretion and in pancreatic enzymes content were observed. The output and the tissue content of amylase were significantly reduced in diabetic rats, while the output and the content of lipase were increased. Plasma secretin and cholecystokinin (CCK) concentrations of diabetic rats were significantly increased compared to those of normal rats. The...
162.

Identification of ATP-sensitive K+ Conductances in Male Rat Major Pelvic Ganglion Neurons

Kyu-SangPark, Seung-KyuCha, Keon-IlLee, JaeYeoulJun, Seong-WooJeong, InDeokKong, JoongWooLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2002, Vol.6 No.5 3 247-254 (8 pages)

Kyu-SangPark, Seung-KyuCha, Keon-IlLee, JaeYeoulJun, Seong-WooJeong, InDeokKong, JoongWooLee 저
...
- 3,000원
Major pelvic ganglia (MPG) neurons are classified into sympathetic and parasympathetic neurons according to the electrophysiological properties; membrane capacitance (Cm), expression of T-type Ca2⁢ channels, and the firing patterns during depolarization. In the present study, function and molecular expression of ATP-sensitive K⁢ (KATP) channels was investigated in MPG neurons of male rats. Only in parasympathetic MPG neurons showing phasic firing patterns, hyperpolarizing changes...
163.

Activation of ATP-sensitive Potassium Channels by the Predominant Metabolite of Isoflurane in Rabbit Ventricular Myocytes

JinHan, NariKim, EuiyongKim, SungjuKim, KangheeCho 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 11 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2001, Vol.5 No.2 7 165-175 (11 pages)

JinHan, NariKim, EuiyongKim, SungjuKim, KangheeCho 저
...
- 4,000원
Background: Recent in vivo experimental evidence suggests that isoflurane-induced cardioprotection may involve KATP channel activation. However, it was demonstrated that isoflurane inhibited KATP channel activities in the inside-out patch mode. To explain this discrepancy, the present investigation tested the hypothesis that a metabolite of isoflurane, trifluoroacetic acid (TFA), contributes to isoflurnae-induced cardioprotection via KATP channel activation during myocardial ischemia and...
164.

Effects of Pretreatment of Serotonin Synthesis Inhibitor p-chlorophenylalanine on Lipopolysaccharide-induced Anorexia in Rats

So-youngPark, ByungSuckKim, SeoungSookBack 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2001, Vol.5 No.2 3 133-138 (6 pages)

So-youngPark, ByungSuckKim, SeoungSookBack 저
...
- 3,000원
In the present study, we investigated the effect of pretreatment of p-chlorophenylalanine (PCPA), inhibitor of serotonin synthesis, on lipopolysaccharide (LPS)-induced anorexia in rats. First of all, effects of PCPA injection on food intake and body weight in rats were investigated. During 4 days of PCPA injection (300 mg/kg BW once a day), food intake was decreased by 33% and daily gain in body weight was inhibited compared with controls. Twenty-four hours after last PCPA injection, food...
165.

Glucose/Oxygen Deprivation Induces Release of [3H]5-hydroxytryptamine Associated with Synapsin 1 Expression in Rat Hippocampal Slices

EunMiPark, SangHuiChu, KyungEunLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2000, Vol.4 No.5 2 347-353 (7 pages)

EunMiPark, SangHuiChu, KyungEunLee 저
...
- 3,000원
It has been well documented that a massive release of not only glutamate but also other neurotransmitters may modulate the final responses of nerve cells to the ischemic neuronal injury. But there is no information regarding whether the release of monoamines is directly associated with synaptic vesicular proteins under ischemia. In the present study, it was investigated whether synapsin 1, syntaxin and SNAP-25 are involved in the release of 5-hydroxytryptamine ([3H]5-HT) in glucose/oxygen...
166.

Effects of Bradykinin on Intracellular Calcium Transients in Cardiac Myocytes

Choon-OkPark, YangMiKim, JaeHeeHan, DavidG.Allen, SeongGeunHong 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1999, Vol.3 No.6 10 615-621 (7 pages)

Choon-OkPark, YangMiKim, JaeHeeHan, DavidG.Allen, SeongGeunHong 저
...
- 3,000원
In spite many evidences has supported the cardioprotective effect of bradykinin, its direct effects at the cell level are still under question. We investigated the both effects of bradykinin (BK) on Ca2⁢-related ionic currents using whole cell voltage clamp technique in rabbit cardiomyocytes and on the intracellular Ca2⁢ transient using calcium sensitive fluorescence dye, indo-1AM. Simultaneously with recording intracellular Ca2⁢ transients, cell contractility was estimated...
167.

Effects of Calcium Channel Blockers on Porcine Cardiac and Coronary Arterial Function in Ischemia-Reperfusion

YungHongBaik, HyunKook, SunHeePark, SeongJooJeong, DongYoonLim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1999, Vol.3 No.6 7 587-595 (9 pages)

YungHongBaik, HyunKook, SunHeePark, SeongJooJeong, DongYoonLim 저
...
- 3,000원
This study was designed to investigate effects of calcium antagonists on endothelial and neuronal dysfunction of right coronary artery (RCA) induced by ischemia- reperfusion in anesthetized, open-chest pigs. After reperfusion, pigs were sacrificed and the RCA was rapidly dissected for in vitro experiments. Experimental groups were divided into 4 groups: control (C-RCA), ischemia-reperfusion only (I-RCA), verapamil infusion (VI-RCA) and nifedipine infusion (NI-RCA) group, respectively. The...
168.

Effects of Dexamethasone and DHEA on the Changes of Glutamate and Polyamine Uptake in Rat Astrocytes by Lipopolysaccharide and Antimycin A

Sang-HyunChoi, BumLee, Kyung-HoShin, Bon-HongMin, Yeon-SookChun, Boe-GwunChun 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 10 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1999, Vol.3 No.2 3 137-146 (10 pages)

Sang-HyunChoi, BumLee, Kyung-HoShin, Bon-HongMin, Yeon-SookChun, Boe-GwunChun 저
...
- 3,000원
Interactions among dexamethasone, dehydroepiandrosterone (DHEA), lipopolysaccharide (LPS), and antimycin A on the glutamate uptake and the polyamine uptake were investigated in primary cultures of rat cerebral cortical astrocytes to examine the effects of dexamethasone and DHEA on the regulatory role of astrocytes in conditions of increased extracellular concentrations of glutamate or polyamines. 1. [3H]Glutamate uptake: LPS and antimycin A decreased Vmax, but both drugs had little effect on...
169.

Increased Activity of Large Conductance Ca2+-Activated K+ Channels in Negatively-Charged Lipid Membranes

JinBongParkPanDongRyu 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 11 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1998, Vol.2 No.4 15 529-539 (11 pages)

JinBongParkPanDongRyu 저
...
- 4,000원
surface charge was predicted by a 3-barrier-2-site model of energy profile for the permeation of K⁢ ions. In conclusion, despite the differences in structure and fluidity of phospholipids in bilayers, the activities of maxi K channels in two charged membranes composed of PS or PI were strikingly similar and larger than those in bilayers of PE. These results suggest that the enhancement of conductance and Po of maxi channels is mostly due to negative charges in the phospholipid head groups.
170.

Naltrexone으로 전처치된 사회적 음주자에서 음주 유발 후 음주 갈망과 혈장 β-endorphin의 변화

김은희, 손인기, 이영식, 나철 대한신경정신의학회 신경정신의학 12 Pages

대한신경정신의학회 신경정신의학 2000, 제 39권 제 4호 10 754-765 (12 pages)

김은희, 손인기, 이영식, 나철 저
...
- 4,100원
연구목적： Opioid 길항제인 날트렉손은 알코올리즘 환자와 정상인의 음주행위에 영향을 준다는 보고가 있다. 그러나 날트렉손의 임상효과에 대한 기전은 아직 명확하지 않다. 이에 저자들은 사회적 음주자에서 날트렉손의 임상 효과 여부와 그 작용기전을 규명하고자 하였다. 방 법： 사회적 음주자 15명을 대상으로 날트렉손을 이중맹검, 교차, 위약대조법으로 1주일간 전처치한 후, 음주 유발 검사를 통하여 알코올의 정신신체반응, 음주에 대한 갈망욕구와 혈장 β-endorphin과 ACTH, 혈청 cortisol 농도의 변화를 비교하였다. 결...

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