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1741.

Wide Spectrum of Inhibitory Effects of Sertraline on Cardiac Ion Channels

Hyang-AeLee, Ki-SukKim, Sung-AeHyun, Sung-GurlPark, SungJoonKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2012, Vol.16 No.5 6 327-332 (6 pages)

Hyang-AeLee, Ki-SukKim, Sung-AeHyun, Sung-GurlPark, SungJoonKim 저
...
- 3,000원
Sertraline is a commonly used antidepressant of the selective serotonin reuptake inhibitors (SSRIs) class. In these experiments, we have used the whole cell patch clamp technique to examine the effects of sertraline on the major cardiac ion channels expressed in HEK293 cells and the native voltage-gated Ca2＋ channels in rat ventricular myocytes. According to the results, sertraline is a potent blocker of cardiac K＋ channels, such as hERG, IKs and IK1. The rank order of inhibitory potency was...
1742.

Antiproliferative and Cytotoxic Effects of Resveratrol in Mitochondria- Mediated Apoptosis in Rat B103 Neuroblastoma Cells

Md.AtaurRahman, Nam-HoKim, Seung-HyukKim, Sung-MinOh, Sung-OhHuh 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2012, Vol.16 No.5 5 321-326 (6 pages)

Md.AtaurRahman, Nam-HoKim, Seung-HyukKim, Sung-MinOh, Sung-OhHuh 저
...
- 3,000원
resveratrol in Rat B103 neuroblastoma cells; although it's molecular mechanisms for the biological effects are not fully defined. Here, we examined the cellular cytotoxicity of resveratrol by cell viability assay, antiproliferation by BrdU assay, DNA fragmentation by DNA ladder assay, activation of caspases and Bcl-2 family proteins were detected by western blot analyses. The results of our investigation suggest that resveratrol increased cellular cytotoxicity of Rat B103 neuroblastoma cells in...
1743.

The Protective Effect of Eupatilin against Hydrogen Peroxide-Induced Injury Involving 5-Lipoxygenase in Feline Esophageal Epithelial Cells

JaeChunLim, SunYoungPark, YoonjinNam, ThanhThaoNguyen, UyDongSohn 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2012, Vol.16 No.5 4 313-320 (8 pages)

JaeChunLim, SunYoungPark, YoonjinNam, ThanhThaoNguyen, UyDongSohn 저
...
- 3,000원
(5,7-dihydroxy-3',4',6-trimethoxyflavone), an extract from Artemisia argyi folium, prevents H2O2-induced injury of cultured feline esophageal epithelial cells. Cell viability was measured by the conventional MTT reduction assay. Western blot analysis was performed to investigate the expression of 5-lipoxygenase by H2O2 treatment in the absence and presence of inhibitors. When cells were exposed to 600 ՌM H2O2 for 24 hours, cell viability was decreased to 40%. However, when cells were...
1744.

Effects of Treadmill Exercise on the Recovery of Dopaminergic Neuron Loss and Muscle Atrophy in the 6-OHDA Lesioned Parkinson's Disease Rat Model

Myoung-AeChoe, Byung-SooKoo, GyeongJuAn, SongheeJeon 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2012, Vol.16 No.5 3 305-312 (8 pages)

Myoung-AeChoe, Byung-SooKoo, GyeongJuAn, SongheeJeon 저
...
- 3,000원
This study was to determine the effect of exercise on the recovery of dopaminergic neuron loss and muscle atrophy in 6-OHDA-induced hemi Parkinson's disease model. Exercise was loaded twice per day for 30 minutes each time, at 5 days after 6-OHDA lesioning and continued for 16 days using a treadmill. Exercise significantly increased the number of tyrosine hydroxylase positive neuron in the lesioned substantia nigra and the expression level of tyrosine hydroxylase in the striatum compared with...
1745.

Dipeptides Inhibit Melanin Synthesis in Mel-Ab Cells through Down-Regulation of Tyrosinase

Hyun-eLee, Eun-HyunKim, Hye-RyungChoi, UyDongSohn, Hye-YoungYun, KwangJinBaek, NyounSooKwon, Kyoung-ChanPark, Dong-SeokKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 5 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2012, Vol.16 No.4 9 287-291 (5 pages)

Hyun-eLee, Eun-HyunKim, Hye-RyungChoi, UyDongSohn, Hye-YoungYun, KwangJinBaek, NyounSooKwon, Kyoung-ChanPark, Dong-SeokKim 저
...
- 1,500원
This study investigated the effects of proline-serine (PS) and valine-serine (VS) dipeptides on melanogenesis in Mel-Ab cells. Proline-serine and VS significantly inhibited melanin synthesis in a concentration-dependent manner, though neither dipeptide directly inhibited tyrosinase activity in a cell-free system. Both PS and VS down-regulated the expression of microphthalmia-associated transcription factor (MITF) and tyrosinase. In a follow-up study also described here, the effects of these...
1746.

Comparison of Neurite Outgrowth Induced by Erythropoietin (EPO) and Carbamylated Erythropoietin (CEPO) in Hippocampal Neural Progenitor Cells

DongHoonOh, InYoungLee, MiyeonChoi, SeokHyeonKim, HyeonSon 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 5 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2012, Vol.16 No.4 8 281-285 (5 pages)

DongHoonOh, InYoungLee, MiyeonChoi, SeokHyeonKim, HyeonSon 저
...
- 1,500원
A previous animal study has shown the effects of erythropoietin (EPO) and its non-erythropoietic carbamylated derivative (CEPO) on neurogenesis in the dentate gyrus. In the present study, we sought to investigate the effect of EPO on adult hippocampal neurogenesis, and to compare the ability of EPO and CEPO promoting dendrite elongation in cultured hippocampal neural progenitor cells. Two-month-old male BALB/c mice were given daily injections of EPO (5 U/g) for seven days and were sacrificed 12...
1747.

The Effect of Methanol on the Structural Parameters of Neuronal Membrane Lipid Bilayers

Hyung-JinJoo, Shin-HoAhn, Hang-RaeLee, Sung-WooJung, Chang-WonChoi, Min-SeokKim, Moon-KyoungBae, In-KyoChung, Soo-KyoungBae, Hye-OckJang, 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 10 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2012, Vol.16 No.4 5 255-264 (10 pages)

Hyung-JinJoo, Shin-HoAhn, Hang-RaeLee, Sung-WooJung, Chang-WonChoi, Min-SeokKim, Moon-KyoungBae, In-KyoChung, Soo-KyoungBae, Hye-OckJang, 저
...
- 3,000원
The structures of the intact synaptosomal plasma membrane vesicles (SPMVs) isolated from bovine cerebral cortexs, and the outer and the inner monolayer separately, were evaluated with 1,6-diphenyl- 1,3,5-hexatriene (DPH) and 1,3-di(1-pyrenyl)propane (Py-3-Py) as fluorescent reporters and trinitrophenyl groups as quenching agents. The methanol increased bulk rotational and lateral mobilities of SPMVs lipid bilayers. The methanol increased the rotational and lateral mobilities of the outer...
1748.

Immunostimulatory Effects of b-glucan Purified from Paenibacillus polymyxa JB115 on Mouse Splenocytes

Ji-MiKim, Hong-GuJoo 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2012, Vol.16 No.4 1 225-230 (6 pages)

Ji-MiKim, Hong-GuJoo 저
...
- 3,000원
splenocytes to determine if treated cells could still undergo clonal expansion. In flow cytometric analysis, Ղ-glucan induced increased levels of the activation marker CD25 on the surface of splenocytes and Ղ-glucan-treated splenocytes showed higher proliferation rates in response to IL-2 treatment. This study demonstrates that Ղ-glucan can enhance the survival of splenocytes and provides valuable information to broaden the use of Ղ-glucan in research fields.
1749.

Activation of the cGMP/Protein Kinase G Pathway by Nitric Oxide Can Decrease TRPV1 Activity in Cultured Rat Dorsal Root Ganglion Neurons

YunjuJin, JunKim, JiyeonKwak 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2012, Vol.16 No.3 10 211-217 (7 pages)

YunjuJin, JunKim, JiyeonKwak 저
...
- 3,000원
Recent studies have demonstrated that nitric oxide (NO) activates transient receptor potential vanilloid subtype 1 (TRPV1) via S-nitrosylation of the channel protein. NO also modulates various cellular functions via activation of the soluble guanylyl cyclase (sGC)/protein kinase G (PKG) pathway and the direct modification of proteins. Thus, in the present study, we investigated whether NO could indirectly modulate the activity of TRPV1 via a cGMP/PKG-dependent pathway in cultured rat dorsal root...
1750.

Tat-Mediated p66shc Transduction Decreased Phosphorylation of Endothelial Nitric Oxide Synthase in Endothelial Cells

SangKiLee, JiYoungLee, HeeKyoungJoo, EunJungCho, CukSeongKim, SangDoLee, JinBongPark, ByeongHwaJeon 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2012, Vol.16 No.3 8 199-204 (6 pages)

SangKiLee, JiYoungLee, HeeKyoungJoo, EunJungCho, CukSeongKim, SangDoLee, JinBongPark, ByeongHwaJeon 저
...
- 3,000원
We evaluated the role of Tat-mediated p66shc transduction on the activation of endothelial nitric oxide synthase in cultured mouse endothelial cells. To construct the Tat-p66shc fusion protein, human full length p66shc cDNA was fused with the Tat-protein transduction domain. Transduction of TAT-p66shc showed a concentration- and time-dependent manner in endothelial cells. Tat-mediated p66shc transduction showed increased hydrogen peroxide and superoxide production, compared with Tat-p66shc...

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