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Effects of Prostaglandin E2 on the Spontaneous Contractions and Electrical Activities of the Antral Circular Muscle in Guinea-pig Stomach
JongYoonKim, SungJoonKim, TongMookKang, SangJinLee, JaeYeoulJun, InsukSo, KiWhanKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1998, Vol.2 No.3 11 361-368 (8 pages)
The spontaneous contractions of gastric smooth muscles are regulated by slow waves, which are modulated by both nervous system and humoral agents. This study was designed to examine the effects of prostaglandin E2 (PGE2) on the contractile and electrical activities of antral smooth muscles in guinea-pig stomach, using an intracellular recording technique. To elucidate the underlying mechanism for its effect on contractility, ionic currents were also measured using a whole-cell patch clamp... -
Comparison of Inodilator Effect of Higenamine, YS49, YS51, Tetrahydroisoquinoline Analogs, and Dobutamine in the Rat
Won-SeogChong, Young-SooLee, Young-JinKang, Duck-HyungLee, Jae-ChunRyu, HyeSookYun-Choi, Ki-ChurlChang 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1998, Vol.2 No.3 7 323-330 (8 pages)
Tetrahydroisoquinoline (THI) alkaloids can be considered as cyclized derivatives of simple phenylethylamines. Many of them, especially with 6,7-disubstitution, demonstrate a relatively high affinity for catecholamines. Present study examines the pharmacological action of limited series of THI, using rats' isolated atria and aorta. In addition, a [3H] prazosin displacement binding study with THI compounds was performed, using rat brain homogenates to investigate whether these probes have... -
Cromakalim Blocks Membrane Phosphoinositide Activated Signals in the Guinea Pig Lung Mast Cells Stimulated with Antigen-Antibody Reactions
JaiYoulRo, JiYoungKim, KyungHwanKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 10 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1998, Vol.2 No.2 14 251-260 (10 pages)
Cromakalim (BRL 34915), known as an airway smooth muscle relaxant, inhibited the releases of mediators in the antigen-induced mast cell activation. It has been suggested that cromakalim, in part, inhibited mediator releases by inhibiting the initial increase of 1,2-diacylglycerol (DAG) produced by the activation of the other phospholipase system which is different from phosphatidylcholine-phospholipase D pathway. The aim of this study is to further examine the inhibitory mechanism of cromakalim... -
Hypoxia-Induced EDNO Release is Further Augmented by Previous Hypoxia and Reoxygenation in Rabbit Aortic Endothelium
JaeJinHan, SukHyoSuh, KyungPhilSuh, KiWhanKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1998, Vol.2 No.2 9 209-216 (8 pages)
by prostaglandin F2α (3×10-6 M/L), which was added to the solution perfusing through the aortic segment. Hypoxia was evoked by switching the solution aerated with 95% O2/5% CO2 mixed gas to one aerated with 95% N2/5% CO2 mixed gas. When the contraction induced by prostaglandin F2α reached a steady state, the solution was exchanged for hypoxic one. And then, hypoxia and reoxygenation were interchanged at intervals of 2 minutes (intermittent hypoxia). The endothelial cells were also exposed to... -
Changes in Cytosolic Ca2+ but not in cGMP Contents May be more Important to Nitric Oxide-Mediated Relaxation in Depolarized Vascular Smooth Muscle
HyunSeokLeeKiChurlChang 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1998, Vol.2 No.1 8 63-68 (6 pages)
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기니픽의 회장평활근에서 NANC 신경전달물질의 작용기전
이영호, 김종훈, 강복순 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 14 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1997, Vol.1 No.6 20 783-796 (14 pages)
Action Mechanisms of NANC Neurotransmitters in Smooth Muscle of Guinea Pig Ileum. 2 -. T1IO .. n r 1 Young-Ho Lee', Jong-Hoon Kim -
비-혈관평활근에서 새로운 K+ 동로 개방제인 SKP-450의 약리 학적 작용의 특성 -Levcromakalim의 작용과 비 교
홍기환, 박지영, 김현희, 유성은 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1997, Vol.1 No.6 17 759-767 (9 pages)
A Novel K+ Channel Opener, in Non-Vascular Smooth Muscles in Comparison with Levcromakalim. Ki Whan HongI, Ji Young Park\ Hyun Hee Kim\ and Sung-Eun Y002 lDepartment of Pharmacology, College of Medicine, Pusan National University, Pusan, 602-739; and 2Korea Research Institute of Chemical Technology, Daejeon, Korea In the present study, we characterized the non-vascu1ar smooth musc1e relaxant effects of a novel benzoyran derivative, SKP-450 (2- [2" (1" ,3" -dioxolone)-2-methyl-4-(2’... -
기니픽 심장과 심근 세포에서 α1-Adrenergic 자극에 의한 Mg2+ 유리조절 Regulation of Mg2+ Release in Guinea Pig Heart and Isolated Ventricular Myocytes by Ձ1-Adrenergic Stimulation
강형섭, 장성은, 김진상, Hyung-SubKang, Sung-EunChang, Jin-SangKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 14 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1997, Vol.1 No.6 13 717-730 (14 pages)
hearts or isolated myocytes. The Mg2 content of the perfusate or the supernatant was measured by atomic absorbance spectrophotometry. The elimination of Mg2 in the medium increased the force of contraction of right ventricular papillary muscles. Phenylephrine also enhanced the force of contraction in the presence of Mg2-free medium. α1-Agonists such as phenylephrine were found to induce Mg2 efflux in both perfused hearts or myocytes. This was blocked by prazosin, a... -
흰쥐 심근의 역 사다리 효과에 있어서 생후 연령에 따른 Na+-Ca2+ 교환의 역할에 관한 연구 Studies on the Roles of Na+-Ca2+ Exchange according to Postnatal Age in the Negative Staircase Effect of the Rat Heart
이해용, 김순진, 고창만, Hae-yongLee, SoonJinKimChangMannKo 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 10 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1997, Vol.1 No.6 12 707-716 (10 pages)
Recent reports revealed that the Na-Ca2 exchangers and feet structures of sarcoplasmic reticulum(SR) are located in close vicinity in the specific compartment. Therefore, we investigated the possibility that the Na-Ca2 exchanger may decrease the tension development by transporting the Ca2 out of the cell right after it released from SR, on the basis of this anatomical proximity. We exammined the negative force-frequency relationship of the developed tension in... -
Altered Vascular Calcium Regulation in Hypertension
Won-jaeKim, Jong-unLee, YongHyunPark, SangChaeNam 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1997, Vol.1 No.5 8 529-535 (7 pages)
in control. Ryanodine, calcium channel activator of the sarcoplasmic reticulum, attenuated the restoration of caffeine-induced vascular contraction, which was not affected by either 2K1C or DOCA-salt hypertension. Nifedipine, an L-type Ca2 channel blocker, attenuated the restoration of caffeine-induced contraction, which was not affected by DOCA-salt hypertension, but was more pronounced in 2K1C hypertension. Nifedipine also diminished the vascular 45Ca uptake, which was not affected by...


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