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171.

Effect of Ca2+-channel Blockers on Norepinephrine Release in the Rat Hippocampal Slice and Synaptosome

SukWonKim, KyuYongJung, BongKyuChoi 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2002, Vol.6 No.2 4 87-92 (6 pages)

SukWonKim, KyuYongJung, BongKyuChoi 저
...
- 3,000원
in the synaoptosomes without any effect in the slice, but the effect of decrement was far less than that of ω-CTxGVIA. In interaction experiments with ω-CTxGVIA, ω-CTxMVIIC slightly potentiated the effect of ω-CTxGVIA on NE release in the slice and synaptosomal preparations. These results suggest that the NE release in the rat hippocampus is mediated mainly by N-type Ca2⁢-channels, and that other types such as L-, T- and/or P/Q-type Ca2⁢-channels could also be participate in this...
172.

Muscarine M2 Receptor-mediated Presynaptic Inhibition of GABAergic Transmission in Rat Meynert Neurons

Il-SungJangNorioAkaike 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2002, Vol.6 No.2 1 63-70 (8 pages)

Il-SungJangNorioAkaike 저
...
- 3,000원
on GABAergic mIPSCs was completely occluded in the presence of forskolin. The results suggest that muscarine acts presynaptically and reduces the probability of spontaneous GABA release, and that such muscarine-induced inhibitory action seems to be mediated by G-protein-coupled M2 receptors, via the reduction of cAMP production. Accordingly, M2 receptor-mediated disinhibition of nBM neurons might play one of important roles in the regulation of cholinergic outputs from nBM neurons as well as the...
173.

Effect of Propofol on Ion Channels in Acutely Dissociated Dorsal Raphe Neuron of Sprague-Dawley Rats

Bong-JaeLee, Moo-IlKwon, Min-ChulShin, Youn-JungKim, Chang-JuKim, SoonAeKim, Ee-HwaKim, Joo-HoChung 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2001, Vol.5 No.2 10 189-197 (9 pages)

Bong-JaeLee, Moo-IlKwon, Min-ChulShin, Youn-JungKim, Chang-JuKim, SoonAeKim, Ee-HwaKim, Joo-HoChung 저
...
- 3,000원
M) potentiated GABAA-, glycine- and NMDA receptor-mediated currents. The potentiating action of propofol on GABAA-, glycine- and NMDA receptor-mediated responses involved neither opioid receptors nor G-proteins. Apparently, propofol modulates inhibitory and excitatory neurotransmitter-activated ion channels either by acting directly on the receptors or by potentiating the effects of the neurotransmitters, and this modulation appears to be responsible for the majority of the anaesthetic and/or...
174.

The Hyperthermic Effect of Nitric Oxide in Central Nervous System

Jae-KyungJung, UyDongSohn, Seok-YongLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2001, Vol.5 No.1 13 93-98 (6 pages)

Jae-KyungJung, UyDongSohn, Seok-YongLee 저
...
- 3,000원
The precise mechanism of set-point regulation in hypothalamus was not elucidated. Nitric oxide synthases(NOS) were detected in hypothalamus, however, the roles of NO in hypothalamus was not fully studied. So, we tested the effects of NO on body temperature because preoptic-anterior hypothalamus was known as the presumptive primary fever-producing site. NO donor sodium nitroprusside (SNP, 4 nmol, i.c.v.) elicited marked febrile response, and this febrile response was completely blocked by...
175.

The Effect of Carbon Monoxide on Contraction, Cytosolic Ca2+ Level and Ionic Currents in Guinea Pig Ileal Smooth Muscle

SeongChunKwon, SeungSooChung, YunSukKim, TaickSangNam 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2000, Vol.4 No.6 6 471-477 (7 pages)

SeongChunKwon, SeungSooChung, YunSukKim, TaickSangNam 저
...
- 3,000원
by cumulative addition of KCl was only slightly decreased in the presence of CO, and the [Ca2⁢]i-tension relationship shifted downwards. Using the patch clamp technique with a holding potential of ⁣60 mV, we found that CO had little effect on the peak Ba currents (IBa) when voltage was stepped from ⁣60 mV to 0 mV. In addition, CO showed no effect on the depolarization-activated outward K⁢ currents in the all potential ranges. We conclude that CO inhibits smooth muscle...
176.

Relaxant Effect of 4-Aminopyridine on the Mesenteric Artery of Rat

Se-HoonKimTae-ImLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2000, Vol.4 No.6 4 455-461 (7 pages)

Se-HoonKimTae-ImLee 저
...
- 3,000원
(4-AP) has an excitatory effect on vascular smooth muscle due to causing membrane depolarization by blocking K⁢-channel. However, we observed that 4-AP had an inhibitory effect on the mesenteric artery of rat. Therefore, we investigated the mechanism of 4-AP-induced vasorelaxation. The mesenteric arcuate artery and its branches were isolated and cut into ring. The ring segment was immersed in HEPES-buffered solution and its isometric tension was measured. 4-AP (0.1∼10 mM) induced a...
177.

Effect of Serotonin Uptake Inhibitors on Serotonin Metabolism in the Hypothalamus of Freely Moving Rats

YunSeobSong, SeNaYoon, DongSikJung, SangHeeYoo, HyongKyunRyu, HyungGunKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 11 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2000, Vol.4 No.6 1 427-437 (11 pages)

YunSeobSong, SeNaYoon, DongSikJung, SangHeeYoo, HyongKyunRyu, HyungGunKim 저
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- 4,000원
MPOA was clomipramine, sertraline, paroxetine and fluoxetine and the concentrations of 5-HIAA was vice versa. The changes in serotonin concentration at the MPOA appeared closely associated with the clinical effects of these drugs on premature ejaculation. These results suggest that the serotonergic neuronal activity in the MPOA may have an selective inhibitory influence on ejaculation, and the effects of clomipramine and SSRIs on erectile function are mainly mediated by MPOA of the hypothalamus.
178.

Effect of Heat Shock Protein 72 on the Generation of Reperfusion Arrhythmias

MoonJunChang, HeungSikNa, HyunJungNam, KyungSikPyun, SeungKilHong 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2000, Vol.4 No.4 7 319-324 (6 pages)

MoonJunChang, HeungSikNa, HyunJungNam, KyungSikPyun, SeungKilHong 저
...
- 3,000원
lower than that in control group (p＜0.01). After the ischemia/reperfusion procedure, western blot analysis of HSP72 expression in the myocardial tissues resected from each group was performed. HSP72 production in the AK group was marked, whereas HSP72 was not detected in the AKQ and control groups. These results suggest that the suppressive effect against reperfusion-induced VF induced by amphetamine and ketamine is not mediated by myocardial HSP72 production but by other mechanisms.
179.

Impaired Endothelium-Dependent Relaxation is Mediated by Reduced Production of Nitric Oxide in the Streptozotocin-Induced Diabetic Rats

KyoungSookPark, CukSeongKim, SangWonKang, JinBongPark, Kwang-JinKim, SeokJongChang, ByeongHwaJeon 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2000, Vol.4 No.3 11 263-270 (8 pages)

KyoungSookPark, CukSeongKim, SangWonKang, JinBongPark, Kwang-JinKim, SeokJongChang, ByeongHwaJeon 저
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- 3,000원
To evaluate the involvement of nitric oxide production on the endothelium-dependent relaxation in diabetes, we have measured vascular and endothelial function and nitric oxide concentration, and the expression level of endothelial nitric oxide synthase in the streptozotocin-induced diabetic rats. Diabetic rats were induced by the injection of streptozotocin (50 mg/kg i.v.) in the Sprague-Dawley rats. Vasoconstrictor responses to norepinephrine (NE) showed that maximal contraction to...
180.

Effect of Lidocaine·HCl on Microviscosity of Phosphatidylcholine Model Membrane

In-KyoChung, Inn-SeKim, Chang-HwaChoi, Goon-JaeCho, Jin-BomKim, Woo-SungSon6, Hye-OckJang7, IlYun8 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2000, Vol.4 No.3 9 243-251 (9 pages)

In-KyoChung, Inn-SeKim, Chang-HwaChoi, Goon-JaeCho, Jin-BomKim, Woo-SungSon6, Hye-OckJang7, IlYun8 저
...
- 3,000원
a fluorescence spectroscopic method which can detect the microviscosity of native and model membranes using intramolecular excimerization of 1,3-di(l-pyrenyl)propane (Py-3-Py), we examined the effect of lidocaine·HCl on the microviscosity of model membranes of phosphatidylcholine fraction extracted from synaptosomal plasma membrane vesicles (SPMVPC). The excimer to monomer fluorescence intensity ratio (I'/I) of Py-3-Py in liquid paraffin was a simple linear function of T/η. Based on this...

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