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1851.

Opening of ATP-sensitive K+ Channel by Pinacidil Requires Serine/ Threonine Phosphorylation in Rat Ventricular Myocytes

Yong-GeunKwakSoo-WanChae 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 11 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1999, Vol.3 No.3 7 293-303 (11 pages)

Yong-GeunKwakSoo-WanChae 저
...
- 4,000원
specific protein phosphatase and protein kinase inhibitors on the ATP-sensitive K⁢ (KATP) channel-opening effect of pinacidil were investigated in single rat ventricular myocytes using patch clamp technique. In cell-attached patches, pinacidil (100 μM) induced the opening of the KATP channel, which was blocked by the pretreatment with H-7 (100 μM) whereas enhanced by the pretreatment with genistein (30 μM) or tyrphostin A23 (10 μM). In inside-out patches, pinacidil (10 μM) activated...
1852.

Role of Phospholipase A2 in Oxidant-induced Alteration in Phosphate Transport in Primary Cultured Rabbit Renal Proximal Tubule Cells

KwonMooPark, SunHeeKo, JaeSukWoo, JinSupJung, SangHoLee, YongKeunKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1998, Vol.2 No.5 8 601-609 (9 pages)

KwonMooPark, SunHeeKo, JaeSukWoo, JinSupJung, SangHoLee, YongKeunKim 저
...
- 3,000원
The present study was undertaken to examine the role of phospholipase A2 (PLA2) in oxidant-induced inhibition of phosphate transport in primary cultured rabbit renal proximal tubule cells. Uptakes of phosphate and glucose were dose-dependently inhibited by an oxidant t-butylhydroperoxide (tBHP), and the significant inhibition appeared at 0.025 mM of tBHP, whereas tBHP-induced alterations in lipid peroxidation and cell viability were seen at 0.5 mM. tBHP stimulated arachidonic acid (AA) release...
1853.

Effect of Bromocriptine on 6-Hydroxydopamine-induced Lipid Peroxidation and Cytotoxicity in vitro and in vivo

YongSikKim, SunghoMaeng, ChanWoongPark 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1998, Vol.2 No.5 4 565-572 (8 pages)

YongSikKim, SunghoMaeng, ChanWoongPark 저
...
- 3,000원
The present study was to evaluate the protective effects of bromocriptine, which is known as D2 dopamine receptor agonist and used for the treatment of patients with Parkinson's disease (PD), on 6-hydroxydopamine (6-OHDA)-induced neurotoxicity in vitro and in vivo. Lipid peroxidation product (malondialdehyde; MDA) produced by the administration of 6-OHDA was profoundly reduced following the treatment of bromocriptine in a dose-dependent manner in rabbit brain homogenate. Quinone formation by...
1854.

Altered Renal Nitric Oxide System in Experimental Hypertensive Rats

EunSukYang, JongUnLee, DaeGillKang 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1998, Vol.2 No.4 7 455-460 (6 pages)

EunSukYang, JongUnLee, DaeGillKang 저
...
- 3,000원
The present study was aimed at investigating whether the development of hypertension is related with an altered expression of nitric oxide synthases (NOS) in the kidney. By Western blot analysis, the expression of bNOS and ecNOS isoforms was determined in the kidney of deoxycorticosterone acetate (DOCA)-salt and two-kidney, one clip (2K1C) rats. In DOCA-salt hypertension, the expression of both bNOS and ecNOS was decreased, along with tissue contents of nitrites. In 2K1C hypertension, the...
1855.

Inhibitory Effect of Caffeine on Carbachol-Induced Nonselective Cationic Current in Guinea-Pig Gastric Myocytes

SungJoonKim, KyungWanMin, YoungChulKim, SangJinLee, InsukSo, KiWhanKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1998, Vol.2 No.3 10 353-359 (7 pages)

SungJoonKim, KyungWanMin, YoungChulKim, SangJinLee, InsukSo, KiWhanKim 저
...
- 3,000원
Ca2⁢ release by heparin had no significant effects on the activation of ICCh. When the same cationic current had been induced by intracellular dialysis of GTP[γS] in order to bypass the muscarinic receptor, the inhibitory effect of caffeine was significantly attenuated. The results of this study indicate that both intracellular signalling pathways for ICCh, proximal and distal to G-protein activation, are suppressed by caffeine. A major inhibition was observed at the proximal level.
1856.

Discrepancy between in vitro and in vivo Effect of Gαs Gene Mutation on the mRNA Expression of TRH Receptor

SeungjoonPark, InmyungYang, SungvinYim, JoohoChung, JeechangJung, KyechangKo, YoungseolKim, YoungkilChoi 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1998, Vol.2 No.1 13 101-108 (8 pages)

SeungjoonPark, InmyungYang, SungvinYim, JoohoChung, JeechangJung, KyechangKo, YoungseolKim, YoungkilChoi 저
...
- 3,000원
strong and prolonged contraction in trachealis musc1e strip. Strong tonic contraction by P AF was attenuated
1857.

Association of Dexamethasone-induced Apoptosis and G1-Arrest of Human Leukemic CEM Cells with Polyamine Deficit

Sang-HyunChoi, Jung-AeLee, Yang-SeokChae, Bon-HongMin, Yeon-SookChun, Boe-GwunChun 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 10 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1997, Vol.1 No.4 12 457-466 (10 pages)

Sang-HyunChoi, Jung-AeLee, Yang-SeokChae, Bon-HongMin, Yeon-SookChun, Boe-GwunChun 저
...
- 3,000원
The effects of DFMO or/and putrescine on the dexamethasone-induced apoptosis of CEM cells were studied to investigate the role of polyamines in anti-leukemic glucocorticoid action. Dexamethasone- induced apoptosis was preceded by significant decreases of cellular polyamine contents and putrescine uptake activity. But DFMO produced decreases of putrescine and spermidine contents and marked increase of putrescine uptake activity, but did not induce apoptosis. However, dexamethasone and DFMO,...
1858.

Regulatory Mechanisms of Angiotensin II on the Na+/H+ Antiport System in Rabbit Renal Proximal Tubule Cells. II. Inhibitory Effects of ANG II on Na+ Uptake

HoJaeHan, SooHyunPark, HyunJuKoh 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 10 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1997, Vol.1 No.4 9 425-434 (10 pages)

HoJaeHan, SooHyunPark, HyunJuKoh 저
...
- 3,000원
Many reports represent that angiotensin II (ANG II) caused a dose dependent biphasic effects on fluid transport in the proximal tubule. However, respective roles of different signaling pathways in mediating these effects remain unsettled. The aim of the present study was to examine signaling pathways at high doses of ANG II on the Na+ uptake of primary cultured rabbit renal proximal tubule cells(PTCs) in hormonally defined serum-free medium. High concentrations of ANG II (＞10-9 M) inhibited...
1859.

개 하부식도괄약근의 비아드레날린성, 비콜린성 이완반응에 있어서 Cyclic Nucleotide의 역할 Regulatory Role of Cyclic Nucleotides in Non-Adrenergic Non-Cholinergic Relaxation of Lower Esophageal Sphincter from Dogs

김영태, 임병용, YoungTaeKim, ByungYongRhim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 11 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1997, Vol.1 No.3 9 303-313 (11 pages)

김영태, 임병용, YoungTaeKim, ByungYongRhim 저
...
- 4,000원
The role of the lower esophageal sphincter(LES) is characterized by the ability to maintain tone and to relax allowing the passage of a bolus. It is known that LES relaxation during swallowing may be induced by the cessation of the tonic neural excitation and the activation of non-adrenergic, non-cholinergic(NANC) inhibitory neurons. Furthermore, it is generally accepted that the relaxation of the smooth muscle is mediated primarily by the elaboration of adenosine 3',5'-cyclic...
1860.

Functional Characteristics of Neutral Amino Acid Transporter in Opossum Kidney (OK) Cells

JaeSukWoo, MoonHwanPark, SaeOkOh, JinSupJung, YongKeunKim, SangHoLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1997, Vol.1 No.2 8 185-193 (9 pages)

JaeSukWoo, MoonHwanPark, SaeOkOh, JinSupJung, YongKeunKim, SangHoLee 저
...
- 3,000원
of Na+-dependent cycloleucine uptake was investigated in OK cells with regard to substrate specificity and regulation by protein kinase C (PKC). Inhibition studies with different synthetic and natural amino acids showed a broad spectrum affinity to neutral amino acids regardless of their different side chains including branched or aromatic, indicating that the Na+-dependent cycloleucine uptake in OK cells is mediated by System Bo or System Bo-like transporter rather than the classical System A...

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