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Involvement of Oxidative Stress and Poly(ADP-ribose) Polymerase Activation in 3-Nitropropionic Acid-induced Cytotoxicity in Human Neuroblastoma Cells
EunjooNam, YoungJaeLee, YoungAhOh, JinAhJung, HyeInIm, SeongEunKoh, SunghoMaeng, WanSeokJoo, YongSikKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2003, Vol.7 No.6 6 325-331 (7 pages)
3-Nitropropionic acid (3-NP) inhibits electron transport in mitochondria, leading to a metabolic failure. In order to elucidate the mechanism underlying this toxicity, we examined a few biochemical changes possibly involved in the process, such as metabolic inhibition, generation of reactive oxygen species (ROS), DNA strand breakage, and activation of Poly(ADP-ribose) polymerase (PARP). Exposure of SK-N-BE(2)C neuroblastoma cells to 3-NP for 48 h caused actual cell death, while inhibition of... -
Effects of Dopamine on Intracellular pH in Opossum Kidney Cells
KyungWooKang, YungKyuKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 5 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2003, Vol.7 No.3 11 187-191 (5 pages)
on the NHE activity and counterbalance by dopamine. Our data strongly suggested that chronic dopamine treatment increased intrinsic intracellular buffer capacity, since higher buffer capacity was induced by lower resting pHi and this effect could attenuate pHi changes under extracellular Na-free conditions in chronically dopamine-treated cells. Our study also demonstrated that intracellular acidification induced by chronic dopamine treatments was not mediated by changes in NHE activity. -
Intrinsic Gating in Inward Rectifier Potassium Channels (Kir2.1) with Low Polyamine Affinity Generated by Site Directed Mutagenesis
ISo, , IAshmole, HSoh, CSPark, PJSpencer, MLeyl, PRStanfield, 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 12 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2003, Vol.7 No.3 3 131-142 (12 pages)
We have studied mutant forms of Kir2.1 in which an aspartate residue (D172), important for gating by intracellular polyamines, is replaced by one of three basic residues (Arg, Lys or His). Such channels are highly selective for K+, but show inward rectification that is a shallow function of voltage compared with that found in wild type. This inward rectification occurs with a reduced affinity for spermine and persists in the absence of polyamines. Though the unitary current-voltage relation... -
The Role of K+ Channels on Spontaneous Action Potential in Rat Clonal Pituitary GH3 Cell Line
HyewhonRhim, Hye-JungBaek, Won-KyungHo, YungEEarm 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 10 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2000, Vol.4 No.2 1 81-90 (10 pages)
The types of K channel which determine the pattern of spontaneous action potential (SAP) were investigated using whole-cell variation of patch clamp techniques under current- and voltage-clamp recording conditions in rat clonal pituitary GH3 cells. Heterogeneous pattern of SAP activities was changed into more regular mode with elongation of activity duration and afterhyperpolarization by treatment of TEA (10 mM). Under this condition, exposure of the class III antiarrhythmic agent E-4031... -
Nitric Oxide Impairs the Recovery from Hemorrhagic Hypotension in Conscious Rats
Yoon-yubParkYoung-ManLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1998, Vol.2 No.3 9 345-351 (7 pages)
The role of nitric oxide (NO) in the hemorrhagic hypotension was examined using a NO synthase inhibitor, Nω-nitro-L-arginine methyl ester (L-NAME), in conscious rats. The rats were bled at a constant rate (2 ml/kg/min) through a femoral arterial catheter until the mean arterial pressure (MAP) was reduced by 50 mmHg. We studied the responses to hemorrhage under normal condition (Control) and after the pretreatment with 3 doses of L-NAME (1.6, 8, 40 mg/kg i.v. of NOX1.6, NOX8, and NOX40,... -
뇌허혈 손상에 있어서 해마-세포외액내 Glutamate와 Polyamine 농도의 변동에 관한 연구
신경호(Kyung-Ho Shin), 김형건(Hyung-Gun Kim), 최상현(Sang-Hyun Choi), 조소현(So-Hyun Cho), 천연숙(Yeon-Sook Chun), 전보권(Boe-Gwun Chun) 대한약리학회 대한약리학잡지 18 Pages
대한약리학회 대한약리학잡지 1994, 제 30권 제 3호 2 273-290 (18 pages)
뇌-허혈후 나타나는 신경세포의 손상에 glutamate의 과다한 유리와 그의 N-methyl-D-aspartate (NMDA) 수용체: calcium 통로 활성작용 및 polyamine중 putrescine의 증가로 인한 신경세포내 [Ca2+]의 상승과 관련 있다는 보고들이 있다. 본 연구에서는 Mongolian gerbil에서 5분간 경동맥을 차단하여 뇌-허혈을 가한후 재관류시 해마의 세포외액내 polyamine, glutamate, acetylcholine농도, 해마의 [3H]MK-801 결합능의 변동 및 해마조직소견의 변동에 미치는 비가역성 ornithine decarboxylase (ODC) 억제제인 difluoromethylornithine... -
Rapid Measurement of NH3 and Weak Acid Permeation Through Liposomes and Renal Proximal Tubule Membranes
Bae, Hae-Rahn, Suh, Duck-Joon, Lee, Sang-Ho 대한생리학회 대한생리학회지 12 Pages
대한생리학회 대한생리학회지 1994, 제 28권 제 2호 11 203-214 (12 pages)
Using the methods of stopped-flow and epifluorescence microscopy with entrapped fluorophore, membrane permeability of NH3 and weak acids in liposomes, renal brush border (BBMV) and basolateral membrane vesicles (BLMV), and primary culture cells from renal proximal tubule was measured. Permeability coefficient (cm/sec) of NH3 was (2.9 X 10-2 in phosphatidylcholine liposome 25℃), 5.9 X 10-2 in renal proximal tubule cell (37℃), 4.0 X 10-2 and 2.4 X 10-2 in BBMV and BLMV (25℃), respectively.... -
혈액과 조직의 CO2완충능 및 세포막을 통한 H+농도 경사
황상익(Hwang, Sang-Ik), 박영배(Park, Young-Bae), 민병구(Min, Byoung-Ku), 김우겸(Kim, Woo-Gyeum) 대한생리학회 대한생리학회지 6 Pages
대한생리학회 대한생리학회지 1983, 제 17권 제 2호 4 119-124 (6 pages)
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Taxonomic and Functional Changes of Bacterial Communities in the Rhizosphere of Kimchi Cabbage After Seed Bacterization with Proteus vulgaris JBLS202
Dipto Bhattacharyya, Swarnalee Duta, Sang-Mi Yu, Sang Chul Jeong, Yong Hoon Lee 한국식물병리학회 The Plant Pathology Journal 11 Pages
한국식물병리학회 The Plant Pathology Journal 2018, 34권 4호 3 286-296 (11 pages)
Maintenance of a beneficial microbial community, especially in the rhizosphere, is indispensable for plant growth and agricultural sustainability. In this sense, plant growth-promoting rhizobacteria (PGPR) have been extensively studied for their role in plant growth promotion and disease resistance. However, the impact of introducing PGPR strains into rhizosphere microbial communities is still underexplored. We previously found that the Proteus vulgaris JBLS202 strain (JBLS202) promoted growth... -
Heat Shock Proteins: A Review of the Molecular Chaperones for Plant Immunity
한국식물병리학회 The Plant Pathology Journal 11 Pages
한국식물병리학회 The Plant Pathology Journal 2015, 31권 4호 1 323-333 (11 pages)
As sessile organisms, plants are exposed to persistently changing stresses and have to be able to interpret and respond to them. The stresses, drought, salinity, chemicals, cold and hot temperatures, and various pathogen attacks have interconnected effects on plants, resulting in the disruption of protein homeostasis. Maintenance of proteins in their functional native conformations and preventing aggregation of non-native proteins are important for cell survival under stress. Heat shock proteins...


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