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Comparative effects of angiotensin II and angiotensin-(4-8) on blood pressure and ANP secretion in rats
HoangThiAiPhuong, LameiYu, ByungMunPark, SuhnHeeKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2017, Vol.21 No.6 12 667-674 (8 pages)
with inhibitor of phospholipase (PLC), inositol triphosphate (IP3) receptor, or nonspecific protein kinase C (PKC). The potency of Ang-(4-8) to inhibit ANP secretion was similar to Ang II. However, Ang-(4-8) 10 μM caused an increased mean arterial pressure which was similar to that by 1 nM Ang II. Therefore, we suggest that Ang-(4-8) suppresses high stretch-induced ANP secretion through the AT1R and PLC/IP3/PKC pathway. Ang-(4-8) is a biologically active peptide which functions as an inhibition... -
Trichostatin A Modulates Angiotensin II-induced Vasoconstriction and Blood Pressure Via Inhibition of p66shc Activation
GunKang, YuRanLee, HeeKyoungJoo, MyoungSooPark, Cuk-SeongKim, SungaChoi, ByeongHwaJeon 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2015, Vol.19 No.5 10 467-472 (6 pages)
Histone deacetylase (HDAC) has been recognized as a potentially useful therapeutic target for car-diovascular disorders. However, the effect of the HDAC inhibitor, trichostatin A (TSA), on vasoreactivity and hypertension remains unknown. We performed aortic coarctation at the inter-renal level in rats in order to create a hypertensive rat model. Hypertension induced by abdominal aortic coarctation was significantly suppressed by chronic treatment with TSA (0.5 mg/kg/day for 7 days). Nicotinamide... -
Functional Connections of the Vestibulo-spino-adrenal Axis in the Control of Blood Pressure Via the Vestibulosympathetic Reflex in Conscious Rats
Huan-JunLu, Mei-HanLi, Mei-ZhiLi, SangEonPark, MinSunKim, Yuan-ZheJin, ByungRimPark 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2015, Vol.19 No.5 5 427-434 (8 pages)
Significant evidence supports the role of the vestibular system in the regulation of blood pressure during postural movements. In the present study, the role of the vestibulo-spino-adrenal (VSA) axis in the modulation of blood pressure via the vestibulosympathetic reflex was clarified by immunohis-tochemical and enzyme immunoassay methods in conscious rats with sinoaortic denervation. Expression of c-Fos protein in the intermediolateral cell column of the middle thoracic spinal regions and blood... -
Effects of Vitamin D on Blood Pressure and Endothelial Function
BokyungMin 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2013, Vol.17 No.5 2 385-392 (8 pages)
Vitamin D deficiency is prevalent, primarily due to limited sun exposure, which may be observed in urban areas, or as a result of modern lifestyles. Common myths about vitamin D persist, including that it is mostly obtained from the diet and is only essential for bone and mineral homeostasis. Nonetheless, advances in biomedical science suggest that vitamin D is a hormone that is integral to numerous physiologic functions in most cells and tissues. Therefore, abnormal vitamin D levels may... -
Additive Role of the Vestibular End Organ and Baroreceptors on the Regulation of Blood Pressure in Rats
YanLan, Yan-ZhaoYang, XianJiang, Li-WeiLi, Guang-ShiJin, MinSunKim, ByungRimPark, Yuan-ZheJin 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2013, Vol.17 No.4 15 367-373 (7 pages)
reduced c-Fos protein expression than that in the BL group, and the SAD+BL group showed less expression than that in the SAD group. These results suggest that the vestibular system cooperates with baroreceptors to maintain arterial pressure during hypotension but that baroreceptors regulate arterial pressure during both hypotension and hypertension. Additionally, afferent signals for maintaining blood pressure from the vestibular end organs and the baroreceptors may be integrated in the RVLM. -
Effects of Central GABA and Glutamate on Blood Pressure and Single Unit Spikes in the RVLM of Rats
JaeSikPark, ZeeIhnLee, JaeHeeJang, DongKukAhn 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2002, Vol.6 No.3 4 149-154 (6 pages)
The blood pressure (BP) is regulated by the nervous system and humoral factors, such as renin- angiotensin system, vasopressin and others. In the present study, we examined the central effects of glutamate and GABA on the cardiovascular regulation by injection of these substances into the lateral ventricle and also investigated the relationship between these central effects and the action of angiotensin II (Ang). Male Sprague Dawley rats, 350∼400 g, were anesthetized with urethane and... -
Do Opioid Receptors Play a Role in Blood Pressure Regulation?
Rhee H.M., J.W. Holaday, J.B. Long, M.D. Gaumann, T.L. Yaksh, G.M. Tyce, W.R. Dixon, A.P. Chang, J.A. Mastrianni, R. Mosqueda-Garcia, G. K 대한약리학회 대한약리학잡지 12 Pages
대한약리학회 대한약리학잡지 1988, 제 24권 제 2호 1 153-164 (12 pages)
In anesthetized rabbits met-enkephalin decreased blood pressure and heart rate, which closely paralleled a reduction in sympathetic discharge. Naloxone, but not naloxone methobromide, antagonized these effects, which suggests a central site of action of met-enkephalin. A number of autonomic agents, particularly adrenergic α-and, β-agonists and antagonists modify the cardiovascular actions of met-enkephalin. Experiments in reserpine-treated and adrenalectomized rats provide no evidence of... -
Effect of Blood Pressure on the Endothelium-Dependent Contraction in Rat Aorta
Jeon, Byeong-Hwa, Kim, Hoe-Suk, Kim, Se-Hoon, Chang, Seok-Jong 대한생리학회 대한생리학회지 12 Pages
대한생리학회 대한생리학회지 1996, 제 30권 제 1호 3 21-32 (12 pages)
pressure was suppressed. 4. In aortic rings from 1K,1C-GBH rats, endothelium-dependent contractions by acetylcholine were augmented as compared with WKY. 5. There is good relationship between the value of blood pressure and magnitude of endothelium-dependent contraction. Thus, it is suggested that increased endothelium-dependent contraction in hypertensive rats may he due to the high blood pressure and endothelium-dependent contraction may not be a cause of the initiation of hypertension in SHR.... -
Effects of Morphine on Somatosyrnpathetic Reflex and Arterial Blood Pressure Response Evoked by Stimulation of Peripheral Nerves
Huh, Min-Gang, Yan, Hai-Dun, Lim, Won-Il, Kim, Jun 대한생리학회 대한생리학회지 13 Pages
대한생리학회 대한생리학회지 1995, 제 29권 제 2호 13 309-321 (13 pages)
the present study, the relationship between the somatosympathetic reflexes and arterial blood pressure responses to electrical stimulation of the peripheral nerve was investigated in cats anesthetized with α-chloralose. Single sympathetic postganglionic fiber activities were recorded from the hindlimb muscle and skin nerves and also from the cervical and abdominal sympathetic chains. Effects of the morphine on responses of the sympathetic nerve and arterial blood pressure to activation of the... -
Effect of Blood Pressure on Contractility of Vascular Smooth Muscle and Endothelium-Dependent Relaxation
Suh, Suk-Hyo, Park, Yee-Tae, Lee, Dong-Chul, Seo, Pil-Won, Kim, Ki-Whan 대한생리학회 대한생리학회지 12 Pages
대한생리학회 대한생리학회지 1995, 제 29권 제 2호 10 279-290 (12 pages)
vessels. However, the endothelium-dependent relaxation to acetylcholine and nitroprusside-induced relaxation showed significant differences between the high pressure-exposed and the low pressure-exposed subclavian arteries. From the above results, we suggest that the contractility of vascular smooth muscle is unchanged by the elevated pressure per se. However, the endothelium-dependent relaxation to acetylcholine and the nitroprusside-induced relaxation are attenuated by pressure.


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