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전체 선택해제
총 77건 검색
본문검색 결과만 보기
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Escitalopram, a selective serotonin reuptake inhibitor, inhibits voltage-dependent K+ channels in coronary arterial smooth muscle cells
HanSolKim, HongliangLi, HyeWonKim, SungEunShin, MiSeonSeo, JinRyeolAn, Kwon-SooHa, Eun-TaekHan, Seok-HoHong, Il-WhanChoi, GraceChoi, Dae-su 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2017, Vol.21 No.4 7 415-421 (7 pages)
We investigated the inhibitory effect of escitalopram, a selective serotonin reuptake inhibitor (SSRI), on voltage-dependent K+ (Kv) channels in freshly separated from rabbit coronary arterial smooth muscle cells. The application of escitalopram rapidly inhibited vascular Kv channels. Kv currents were progressively inhibited by an increase in the concentrations of escitalopram, suggesting that escitalopram inhibited vascular Kv currents in a concentration-dependent manner. The IC50 value and... -
Streptozotocin Diabetes Attenuates the Effects of Nondepolarizing Neuromuscular Relaxants on Rat Muscles
LinaHuang, DanChen, ShitongLi 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2014, Vol.18 No.6 3 461-468 (8 pages)
The hypothesis of this study was that diabetes-induced desensitization of rat soleus (SOL) and extensor digitorum longus (EDL) to non-depolarizing muscle relaxants (NDMRs) depends on the stage of diabetes and on the kind of NDMRs. We tested the different magnitude of resistance to vecuronium, cisatracurium, and rocuronium at different stages of streptozotocin (STZ)-induced diabetes by the EDL sciatic nerve-muscle preparations, and the SOL sciatic nerve-muscle preparations from rats after 4 and... -
Response of IKr and hERG Currents to the Antipsychotics Tiapride and Sulpiride
Su-HyunJo, So-YoungLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2010, Vol.14 No.5 9 305-310 (6 pages)
The human ether-a-go-go-related gene (hERG) channel is important for repolarization in human myocardium and is a common target for drugs that prolong the QT interval. We studied the effects of two antipsychotics, tiapride and sulpiride, on hERG channels expressed in Xenopus oocytes and also on delayed rectifier K＋ currents in guinea pig cardiomyocytes. Neither the amplitude of the hERG outward currents measured at the end of the voltage pulse, nor the amplitude of hERG tail currents, showed any... -
Gender-Related Differences in a Process of the Age-Dependent Alterations of the Elements in Monkey Sino-Atrial Node
HiroyasuSatoh, SetsukoTohno, TakeshiMinami, TakaoOishi, MotoharuHayashi, YoshiyukiTohno 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2010, Vol.14 No.5 1 249-256 (8 pages)
Gender differences in the trace elements of monkey sino-atrial (SA) node were investigated in a process of age-dependent alterations. Sixty hearts from Japanese and rhesus monkeys (30 male and 30 female) used were aged ranging from 1-day- to 30-year-old. The elements were analyzed using an inductively coupled plasma-atomic emission spectrometer (ICP-AES). Advancing age decreased all the trace elements. Ca, P, S and Mg significantly decreased. The correlation coefficients of Ca and P were... -
Comparison of Inodilator Effect of Higenamine, YS49, YS51, Tetrahydroisoquinoline Analogs, and Dobutamine in the Rat
Won-SeogChong, Young-SooLee, Young-JinKang, Duck-HyungLee, Jae-ChunRyu, HyeSookYun-Choi, Ki-ChurlChang 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1998, Vol.2 No.3 7 323-330 (8 pages)
and dobutamine increased heart rate and contractile force. In the presence of propranolol, the concentration response curves of YS 49 and YS 51 shifted to the right and resulted in pA2 values of 8.07⁑0.84 and 7.93⁑0.11, respectively. The slope of each compound was not deviated from unity, indicating that these chemicals are highly competitive at the cardiac -adrenoceptors. YS 49, YS 51, and higenamine showed -adrenoceptor affinity in rat brain, in which the dissociati... -
의과대학생과 일반대학생의 삶의 질 비교
민성길, 신원철, 김광일, 정지인, 김동기 대한신경정신의학회 신경정신의학 7 Pages
대한신경정신의학회 신경정신의학 2000, 제 39권 제 6호 8 1054-1060 (7 pages)
연구목적： 미래에 환자들의 신체적, 정신적 건강을 책임지게 될 의과 대학생 집단이 의학을 공부하는 과정에서 어떤 신체적, 정신적 및 사회적 문제들에 의해 고통받는지 알아보고 이의 개선방향을 발견하기 위해, 의과대학생 들이 느끼고 있는 삶의 질에 대한 연구를 실시하였다. 방 법： 1999년도에 연세대학교 의과 대학에 재학중인 본과 학생 317명과, 연세대학교에 재학중인 일반 대학생 150명을 대상으로 설문조사를 하였다. 조사도구는 세계보건기구 삶의 질 간편형 척도(WHOQOL-BREF)였 다. 의과대학생과 일반대학생의 삶의 질을... -
도파민 시스템과 항정신병 약물의 작용에 대한 이해
대한신경정신의학회 신경정신의학 2011, 제 50권 제 4호 3 251-272 (22 pages)
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Haloperidol Decanoate의 임상효과 및 항정상태 약동학
김정익, 김영훈, 신상구 대한신경정신의학회 신경정신의학 15 Pages
대한신경정신의학회 신경정신의학 1990, 제 29권 제 6호 2 1207-1221 (15 pages)
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Effect of X-irradiation on Citrus Canker Pathogen Xanthomonas citri subsp. citri of Satsuma Mandarin Fruits
한국식물병리학회 The Plant Pathology Journal 7 Pages
한국식물병리학회 The Plant Pathology Journal 2015, 31권 4호 3 343-349 (7 pages)
Citrus canker caused by Xanthomonas citri subsp. citri (Xcc) is one of the most important bacterial diseases of citrus. Because citrus canker is not found in many countries including European Union and Australia, Xcc is strictly regulated in order to prevent its spread. In this study, the effects of X-irradiation on Xcc growth either in the suspension or on the surface of citrus fruits were investigated. The suspension containing 1×10 cfu/ml of Xcc was irradiated with different absorbed doses...
