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The Critical Roles of Zinc: Beyond Impact on Myocardial Signaling
SungRyulLee, SuJinNoh, JuliusRyanPronto, YuJeongJeong, HyoungKyuKim, InSungSong, ZhelongXu, HyogYoungKwon, SeChanKang, Eun-HwaSohn, KyungS 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 12 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2015, Vol.19 No.5 1 389-400 (12 pages)
Zinc has been considered as a vital constituent of proteins, including enzymes. Mobile reactive zinc (Zn2+) is the key form of zinc involved in signal transductions, which are mainly driven by its binding to proteins or the release of zinc from proteins, possibly via a redox switch. There has been growing evidence of zinc’s critical role in cell signaling, due to its flexible coordination geometry and rapid shifts in protein conformation to perform biological reactions. The importance and... -
Effect of Defibrotide on Rat Reflux Esophagitis
HyoungKiKim, SooRanChoi, SangJinChoi, MyungSupChio, YongKyooShin 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 10 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2004, Vol.8 No.6 5 319-328 (10 pages)
This study was aimed at evaluating the effect of defibrotide on the development of the surgically induced reflux esophagitis, on gastric secretion, lipid peroxidation, polymorphonuclear leukocytes (PMNs) accumulation, polymorphonuclear leukocytes adherence, superoxide anion and hydrogen peroxide production in PMNs, scavenge of hydroxyl radical and hydrogen peroxide, cytokine (interleukin-1β, tumor necrosis factor-α) production in blood, and intracellular calcium mobilization in PMNs.... -
Prevention of Diabetes Using Adenoviral Mediated Hepatocyte Growth Factor Gene Transfer in Mice
Hye-JeongLee, Hyun-JeongKim, Mee-SookRoh, Jae-IkLee, Sung-WonLee, Dong-SikJung, Duk-KyuKim, Mi-KyoungPark 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2003, Vol.7 No.5 3 261-266 (6 pages)
Type 1 diabetes is an organ-specific autoimmune disease caused by the cytotoxic T cells-mediated destruction of the insulin-producing beta cells in the Langerhans pancreatic islets. Hepatocyte growth factor (HGF) is a potent mitogen and a promoter of proliferation of insulin producing beta cells of pancreatic islets. To study the role of HGF via viral vector in the development of streptozotocin (STZ)-induced diabetes in mice, we have developed an adenoviral vector genetically engineered to carry... -
반복적 스트레스가 흰쥐의 Opioid성 신경전달에 미치는 영향
사공정규, 이광헌, 구본훈, 김진성, 이종범, 하정희 대한신경정신의학회 신경정신의학 9 Pages
대한신경정신의학회 신경정신의학 1999, 제 38권 제 3호 18 638-646 (9 pages)
연구목적： 반복적인 스트레스에 노출된 실험동물에서 opioid성 신경전달의 변화양상을 검색하고 내인성 opioid peptide 의 변화양상을 알아보기 위하여 본 연구를 시행하였다. 방 법： 본 연구에서는 웅성 흰쥐에게 하루 2시간, 2주간의 반복적인 부동화 스트레스를 가한 후 뇌의 각 부위에서 opioid 수용체의 mu-, delta- 및 kappa- 아형의 최대결합력 및 친화력의 변화 양상을 관찰하였다. 결 과： 반복적 부동화 스트레스 노출군에서는 대조군에 비하여 delta-아형 수용체의 수가 시상하부(hypothalamus) 및 선조체(striatum)에서... -
소 부신수실 크롬친화성 세포에서 Nicotine의 장기간 자극으로 유발된 Proenkephalin A mRNA의 증가 및 [Met5]-enkephalin의 분비 증가가 Lipoxygenase 경로에 의해 매개됨
서홍원(Hong-Won Suh), 김영희(Yung-Hi Kim) 대한약리학회 대한약리학잡지 8 Pages
대한약리학회 대한약리학잡지 1993, 제 29권 제 2호 9 237-244 (8 pages)
소 부신수실 크롬친화성 세포(BAMC)에서 [Met5]-enkephalin (ME)의 분비와 Proenkephalin A (proENK) mRNA의 함량에 대한 nicotine의 영향과 이에 대한 indomethacin, nordihydroguaiaretic acid(NDGA) 및 captopril의 작용을 연구하였다. 10 uM Nicotine으로 BAMC 세포를 장기간 자극시 proENK mRNA의 함량과 배양액으로의 ME 분비가 유의하게 증가하였다. BAMC 세포를 NDGA(lipoxygenase 억제제, 10 uM), indomethacin (cyclooxygenase 억제제), captopril (angiotensin 변환효소 억제제)만으로 처리시에는 ME 분비와 proENK mRNA의... -
Interaction between Renin-Angiotensin and Endothelium-Derived Nitric Oxide Systems in Two-Kidney, One Clip Hypertensive Rats
Ahn, Hyun-Tack, Nah, Kook-Joo, Lee, Jong-Un 대한생리학회 대한생리학회지 10 Pages
대한생리학회 대한생리학회지 1996, 제 30권 제 1호 4 33-42 (10 pages)
The present study was aimed to investigate the role of endothelium-derived nitric oxide (NO) in the control of renin release and to examine if NO is implicated in the development of two-kidney, one clip (2K1C) hypertension. Male Sprague-Dawley rats (150 ~ 200 g) were constricted at the left renal artery. They were then supplemented with NG-nitro-L-arginine methyl ester (L-NAME, 5mg/100 mL) or with L-arginine hydrochloride (400 mg/100 mL) in the drinking water. The control group was supplied... -
Proteomic Changes in the Sound Vibration-Treated Arabidopsis thaliana Facilitates Defense Response during Botrytis cinerea Infection
Ritesh Ghosh, Bosung Choi, Young Sang Kwon, Tufail Bashir, Dong-Won Bae, Hanhong Bae 한국식물병리학회 The Plant Pathology Journal 14 Pages
한국식물병리학회 The Plant Pathology Journal 2019, 35권 6호 7 609-622 (14 pages)
Sound vibration (SV) treatment can trigger various molecular and physiological changes in plants. Previously, we showed that pre-exposure of Arabidopsis plants to SV boosts its defense response against Botrytis cinerea fungus. The present study was aimed to investigate the changes in the proteome states in the SV-treated Arabidopsis during disease progression. Proteomics analysis identified several upregulated proteins in the SVinfected plants (i.e., SV-treated plants carrying Botrytis...
