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Predominant D1 Receptors Involvement in the Over-expression of CART Peptides after Repeated Cocaine Administration
ZhenzhenHu, Eun-HyeOh, YeonBokChung, JinTaeHong, Ki-WanOh 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2015, Vol.19 No.2 2 89-97 (9 pages)
the locomotor activity, CART over-expression, pCREB and PKA activity than raclopride. Cocaine induced-behavioral sensitization was also attenuated in the both D1R and D2R knockout (KO) mice, respectively. CART over-expression and activated cAMP/PKA/pCREB signal pathways were inhibited in the D1R-KO mice, but not in the D2R-KO mice. It is suggested that behavioral sensitization, CART over-expression and activated cAMP/PKA/pCREB signal pathways induced by repeated administration of cocaine could ... -
cAMP/PKA Agonist Restores the Fasting-Induced Down-Regulation of nNOS Expression in the Paraventricular Nucleus
SangBaeYoo, SeoulLee, JooYoungLee, Bom-TaeckKim, Jong-HoLee, JeongWonJahng 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 5 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2012, Vol.16 No.5 7 333-337 (5 pages)
after drug injections, rats were transcardially perfused with 4% paraformaldehyde, and the PVN tissues were processed for nNOS or pCREB immunohistochemistry. Sp-cAMP significantly increased not only nNOS but also pCREB immunoreactivities in the PVN of food deprived rats. Fasting- induced down-regulation of the PVN-nNOS was restored by 1 h after the icv Sp-cAMP. Results suggest that cAMP/PKA pathway may mediate the regulation of the PVN-nNOS expression depending on different feeding conditions. -
Effects of Repeated Citalopram Treatments on Chronic Mild Stress- Induced Growth Associated Protein-43 mRNA Expression in Rat Hippocampus
Sang-HaPark, Song-hyenChoi, JiminLee, SeungwooKang, You-ChanShin, Hyun-JuKim, HyunJungKim, SeungKeonShin, Min-SooLee, Kyung-HoShin 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2008, Vol.12 No.3 5 117-124 (8 pages)
Although growth associated protein-43 (GAP-43) is known to play a significant role in the regulation of axonal growth and the formation of new neuronal connections in the hippocampus, there is only a few studies on the effects of acute stress on GAP-43 mRNA expression in the hippocampus. Moreover, the effects of repeated citalopram treatment on chronic mild stress (CMS)-induced changes in GAP-43 mRNA expression in the hippocampus have not been explored before. To explore this question, male rats... -
흰쥐 뇌에서 전기경련 충격에 의한 CREB 인산화의 발달단계에 따른 변화
강웅구, 정희연, 안용민, 정선주, 전송희, 박주배, 조수철, 김용식 대한신경정신의학회 신경정신의학 8 Pages
대한신경정신의학회 신경정신의학 1999, 제 38권 제 3호 16 622-629 (8 pages)
연구목적： 이 논문에서는 뇌에서 전기경련 충격(Electroconvulsive shock, ECS)에 의한 전사인자 CREB의 인산 화를 발달단계에 따라 알아봄으로써 정신장애의 신경발달학적 이해를 위한 생물학적 기반지식을 얻고자 하였다. 방 법： 생후 7, 14, 21일 및 성년 흰쥐에 ECS를 가하고 시간별로 해마 및 소뇌 조직을 얻어 CREB의 인산화를 알아 보기 위해 특이 항체로 면역블롯을 실시하였다. 결 과： 발달단계에 따라 해마에서는 CREB이 감소한 반면 소뇌에서는 CREB이 증가하였다. 기저상태의 CREB 인산화는 해마와 소뇌에서 생후 7일에... -
Regulation of Phosphorylated cAMP Response Element-Binding Protein, Fos-Related Antigen and FosB Expression by Dopamine Agonists in Rat Striatum
EunSangChoeJongYeonKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2001, Vol.5 No.4 2 299-305 (7 pages)
(5 mg/kg, i.p.) significantly increased pCREB-IR at 20 min, sustained up to 60 min and decreased at 120 min after the infusion. Like amphetamine, the full D1 agonist, SKF82958 (0.5 mg/kg, s.c.), also increased pCREB-IR at 20 min, but not at 120 min after the infusion in the dorsal striatum (caudoputaman, CPu) and shell of ventral striatum (nucleus accumbens, NAc). In contrast, FRA- and FosB-IR induced by SKF82958 was significantly increased at 120 min, but not at 20 min after the administration.... -
Markers in Morphine- and Cocaine-Addicted Animals
Hu. Zhenzhen, Park. Kwang-Soon, Han. Jin-Yi, Jang. Choon-Gon, Oh. Sei-Kwan, Kim. Hyoung-Chun, Yang. Chae-Ha, Kim. Eun-Jeong, Oh. Ki-Wan 한국응용약물학회 Biomolecules & therapeutics 7 Pages
한국응용약물학회 Biomolecules & therapeutics 2011, Vol.19 No.1 45-51 (7 pages)
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장기간 플루세틴 처리에 의한 흰쥐 해마에서의 NCAM140 유전자 발현의 증가
최미란, 채영규, 정경화, 백승연, 김석현, 노성원, 최준호, 이준석, 최인근, 양병환, Choi. Mi Ran, Chai. Young Gyu, Jung. Kyoung Hwa, Baik. Seung Youn, Kim. Seok Hyeon, Roh. Sung 대한생물정신의학회 생물정신의학 10 Pages
대한생물정신의학회 생물정신의학 2009, Vol.16 No.1 5-14 (10 pages)
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Inhibitory Action of the Ginseng Total Saponin on the Nalbuphine-Induced Tolerance and Withdrawal Syndrome
Kim. Dong-Hyun, Yoo. Hwan-Soo, Jang. Choon-Gon, Kang. Jong-Seok, Kim. Dong-Sup, Choi. Ki-Hwan, Jang. So-Yong, Oh. Sei-Kwan 고려인삼학회 Journal of ginseng research 8 Pages
고려인삼학회 Journal of ginseng research 2005, Vol.29 No.2 86-93 (8 pages)
