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191.

Chronic Administration of Baicalein Decreases Depression-Like Behavior Induced by Repeated Restraint Stress in Rats

BombiLee, BongjunSur, JinheePark, Sung-HunKim, SunohKwon, MijungYeom, InsopShim, HyejungLee, Dae-hyunHahm 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 11 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2013, Vol.17 No.5 3 393-403 (11 pages)

BombiLee, BongjunSur, JinheePark, Sung-HunKim, SunohKwon, MijungYeom, InsopShim, HyejungLee, Dae-hyunHahm 저
...
- 4,000원
Baicalein (BA), a plant-derived active flavonoid present in the root of Scutellaria baicalensis, has been widely used for the treatment of stress-related neuropsychiatric disorders including depression. Previous studies have demonstrated that repeated restraint stress disrupts the activity of the hypothalamic-pituitary-adrenal (HPA) axis, resulting in depression. The behavioral and neurochemical basis of the BA effect on depression remain unclear. The present study used the forced swimming test...
192.

Effects of Fluvastatin on the Pharmacokinetics of Repaglinide: Possible Role of CYP3A4 and P-glycoprotein Inhibition by Fluvastatin

Chong-KiLee, Jun-ShikChoi, JoonSeokBang 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2013, Vol.17 No.3 10 245-251 (7 pages)

Chong-KiLee, Jun-ShikChoi, JoonSeokBang 저
...
- 3,000원
The purpose of this study was to investigate the effects of fluvastatin on the pharmacokinetics of repaglinide in rats. The effect of fluvastatin on P-glycoprotein and CYP3A4 activity was evaluated. The pharmacokinetic parameters and blood glucose concentrations were also determined after oral and intravenous administration of repaglinide to rats in the presence and absence of fluvastatin. Fluvastatin inhibited CYP3A4 activity in a concentration-dependent manner with a 50% inhibition...
193.

Synergistic Induction of iNOS by IFN-g and Glycoprotein Isolated from Dioscorea batatas

PhamThiThuHuong, MinYoungLee, KunYeongLee, InYoupChang, SeogKiLee, SangPilYoon, Dong-CheolLee, YoungJinJeon 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2012, Vol.16 No.6 9 431-436 (6 pages)

PhamThiThuHuong, MinYoungLee, KunYeongLee, InYoupChang, SeogKiLee, SangPilYoon, Dong-CheolLee, YoungJinJeon 저
...
- 3,000원
Dioscorea species continue to be used in traditional Chinese medicine, and represent a major source of steroid precursors for conventional medicine. In the previous study, We isolated glycoprotein (GDB) from Dioscorea batatas, characterized, and demonstrated immunostimulating activity in C57BL/6 mice. The aim of this study was to investigate the mechanism whereby GDB activates macrophages. Macrophages activation by GDB was investigated by analyzing the effects of GDB on nitric oxide (NO)...
194.

Antiproliferative and Cytotoxic Effects of Resveratrol in Mitochondria- Mediated Apoptosis in Rat B103 Neuroblastoma Cells

Md.AtaurRahman, Nam-HoKim, Seung-HyukKim, Sung-MinOh, Sung-OhHuh 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2012, Vol.16 No.5 5 321-326 (6 pages)

Md.AtaurRahman, Nam-HoKim, Seung-HyukKim, Sung-MinOh, Sung-OhHuh 저
...
- 3,000원
Resveratrol, a natural compound, has been shown to possess anti-cancer, anti-aging, anti-inflammatory, anti-microbial, and neuroprotective activities. In this study, we examined the antiproliferative and cytotoxicity properties of resveratrol in Rat B103 neuroblastoma cells; although it's molecular mechanisms for the biological effects are not fully defined. Here, we examined the cellular cytotoxicity of resveratrol by cell viability assay, antiproliferation by BrdU assay, DNA fragmentation by...
195.

Immunostimulatory Effects of b-glucan Purified from Paenibacillus polymyxa JB115 on Mouse Splenocytes

Ji-MiKim, Hong-GuJoo 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2012, Vol.16 No.4 1 225-230 (6 pages)

Ji-MiKim, Hong-GuJoo 저
...
- 3,000원
We investigated the effects of Ղ-glucan purified from Paenibacillus polymyxa JB115 on the viability and proliferation of splenocytes. Splenocytes play a critical role in host immunity. MTT assays and trypan blue exclusion tests revealed that Ղ-glucan significantly promoted the viability and proliferation of splenocytes over a range of concentrations. However, there was no specific subset change. Ղ-glucan protected splenocytes from cytokine withdrawal-induced spontaneous cell...
196.

Reduction of Food Intake by Fenofibrate is Associated with Cholecystokinin Release in Long-Evans Tokushima Rats

Mi-KyoungPark, YingHan, , MiSunKim, , EunhuiSeo, SoojeongKang, So-YoungPark, HyeongjongKoh, DukKyuKim, Hye-JeongLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2012, Vol.16 No.3 5 181-186 (6 pages)

Mi-KyoungPark, YingHan, , MiSunKim, , EunhuiSeo, SoojeongKang, So-YoungPark, HyeongjongKoh, DukKyuKim, Hye-JeongLee 저
...
- 3,000원
Fenofibrate is a selective peroxisome proliferator-activated receptor Ձ (PPARՁ) activator and is prescribed to treat hyperlipidemia. The mechanism through which PPARՁ agonists reduce food intake, body weight, and adiposity remains unclear. One explanation for the reduction of food intake is that fenofibrate promotes fatty acid oxidation and increases the production of ketone bodies upon a standard experimental dose of the drug (100∼300 mg/kg/day). We observed that low-dose...
197.

Phellodendron amurense and Its Major Alkaloid Compound, Berberine Ameliorates Scopolamine-Induced Neuronal Impairment and Memory Dysfunction in Rats

BombiLee, BongjunSur, InsopShim, HyejungLee, Dae-HyunHahm 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 11 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2012, Vol.16 No.2 1 79-89 (11 pages)

BombiLee, BongjunSur, InsopShim, HyejungLee, Dae-HyunHahm 저
...
- 4,000원
We examine whether Phellodendron amurense (PA) and its major alkaloid compound, berberine (BER), improved memory defects caused by administering scopolamine in rats. Effects of PA and BER on the acetylcholinergic system and pro-inflammatory cytokines in the hippocampus were also investigated. Male rats were administered daily doses for 14 days of PA (100 and 200 mg/kg, i.p.) and BER (20 mg/kg, i.p.) 30 min before scopolamine injection (2 mg/kg, i.p.). Daily administration of PA and BER improved...
198.

Bile Acid Inhibition of N-type Calcium Channel Currents from Sympathetic Ganglion Neurons

HyeKyungLee, KyoungHwaLee, Eui-SicCho 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2012, Vol.16 No.1 4 25-30 (6 pages)

HyeKyungLee, KyoungHwaLee, Eui-SicCho 저
...
- 3,000원
Under some pathological conditions as bile flow obstruction or liver diseases with the enterohepatic circulation being disrupted, regurgitation of bile acids into the systemic circulation occurs and the plasma level of bile acids increases. Bile acids in circulation may affect the nervous system. We examined this possibility by studying the effects of bile acids on gating of neuronal (N)-type Ca2＋ channel that is essential for neurotransmitter release at synapses of the peripheral and central...
199.

Cigarette Smoke Extract-induced Reduction in Migration and Contraction in Normal Human Bronchial Smooth Muscle Cells

ChulHoYoon, Hye-JinPark, Young-WooCho, Eun-JinKim, JongDeogLee, KeeRyeonKang, JaeheeHan, DawonKang 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2011, Vol.15 No.6 11 397-404 (8 pages)

ChulHoYoon, Hye-JinPark, Young-WooCho, Eun-JinKim, JongDeogLee, KeeRyeonKang, JaeheeHan, DawonKang 저
...
- 3,000원
The proliferation, migration, cytokine release, and contraction of airway smooth muscle cells are key events in the airway remodeling process that occur in lung disease such as asthma, chronic obstruction pulmonary disease, and cancer. These events can be modulated by a number of factors, including cigarette smoke extract (CSE). CSE-induced alterations in the viability, migration, and contractile abilities of normal human airway cells remain unclear. This study investigated the effect of CSE on...
200.

4-phenylbutyric Acid Regulates Collagen Synthesis and Secretion Induced by High Concentrations of Glucose in Human Gingival Fibroblasts

Geum-HwaLee, Hyo-WonOh, Hyun-DaeLim, WanLee, Han-JungChae, Hyung-RyongKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2011, Vol.15 No.6 5 345-352 (8 pages)

Geum-HwaLee, Hyo-WonOh, Hyun-DaeLim, WanLee, Han-JungChae, Hyung-RyongKim 저
...
- 3,000원
High glucose leads to physio/pathological alterations in diabetes patients. We investigated collagen production in human gingival cells that were cultured in high concentrations of glucose. Collagen synthesis and secretion were increased when the cells were exposed to high concentrations of glucose. We examined endoplasmic reticulum (ER) stress response because glucose metabolism is related to ER functional status. An ER stress response including the expression of glucose regulated protein 78...

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