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- 대한약리학회(61)
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- THE KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY(144)
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전체 선택해제
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Regulatory Action of Protein Tyrosine Kinase in Intracellular Calcium Mobilization in C5a-stimulated Neutrophils
최원태(Won-Tae Choi), 한은숙(Eun-Sook Han), 이정수(Chung-Soo Lee) 대한약리학회 대한약리학잡지 8 Pages
대한약리학회 대한약리학잡지 1996, 제 32권 제 3호 13 417-424 (8 pages)
of [Ca2+]i was inhibited by genistein and methyl-2,5-dihydroxycinnamate but was not affectd by staurosporine and H-7. Genistein and methyl-2,5-dihydroxycinnamate reduced the store-regulated Ca2+ influx in thapsigargin-treated neutrophils, while the effect of staurosporine and H-7 was not detected. When neutrophils were preincubated wih phorbol 12-myristate 13-acetate, the stimulatory effect of C5a on the elevation of [Ca2+]i was reduced. These results suggest that protein tyrosine kinase may be... -
In Vitro Regeneration of Carcinogen Thioacetamide Treated Rat Hepatocytes
유소영(So-Young Yoo), 김규원(Kyu-Won Kim), 이혜정(Hye-Jeong Lee), 최용천(Yong-Chun Choi) 대한약리학회 대한약리학잡지 8 Pages
대한약리학회 대한약리학잡지 1996, 제 32권 제 3호 11 399-406 (8 pages)
a protein modifying agent. It causes nucleolar hypertrophy in short term treatment. In the present work, thioacetamide treated hepatocytes were observed in vivo and in vitro conditions. After 7 day treatment of rat liver with thioacetamide, the hepatocyte nucleoli were enlarged and their signalling molecules such as B23 and p38 MAPK were increased. When these hepatocytes were released by collagenases and were grown under the conditions of gene therapy grade tissue culture system, the enlarged... -
Barbiturates가 소의 신선한 대뇌피질 Synaptosomal Plasma Membrane Vesicles로 부터 추출하여 제제한 Phosphatidylethanolamine 인공세포막의 유동성에 미치는 영향
윤일(Il Yun), 김형일(Hyung-Il Kim), 황태호(Tae-Ho Hwang), 김종렬(Jong-Ryoul Kim), 김인세(In-Se Kim), 정용자(Yong-Za Chung), 신영희(Yong-Hee Shin), 정현옥(Hyun 대한약리학회 대한약리학잡지 10 Pages
대한약리학회 대한약리학잡지 1990, 제 26권 제 2호 13 209-218 (10 pages)
Barbiturates가 분자적 약리작용기전 탐구에 기초자료를 제공하기 위하여 소의 신선한 대뇌피질 synaptosomal plasma membrane vesicles로부터 분리제제한 phosphatidylethanolamine인공세포막(SPMVPE)의 유동성에 미치는 barbiturates의 영향을 형광 probe법으로 검색한 결과는 다음과 같다. 1. Pentobarbital, hexobarbital, amobarbital 및 phenobarbital이 기재한 순위로 SPMVPE내 Py-3-Py의 monomer 형광세기에 대한 excimer 형광세기의 비 (I /I)를 감소시켰다. 2. Pentobarbital, hexobarbital, amobarbital 및 phenobarbital이... -
Effects of Insulin and IGFs on Phosphate Uptake in Primary Cultured Rabbit Renal Proximal Tubule Cells
Han, Ho-Jae, Park, Kwon-Moo 대한생리학회 대한생리학회지 14 Pages
대한생리학회 대한생리학회지 1996, 제 30권 제 1호 7 63-76 (14 pages)
inhibitory effect. However, staurosporine had no effect on phosphate uptake. When PMA and staurosporine were treated together, inhibition of phosphate uptake was not observed. In conclusion, phosphate uptake is stimulated by high sodium and low phosphate and pH 6.5 in the culture medium. Membrane potential and intracellular energy levels are also an important factor fer phosphate transport. Insulin and IGF-I stimulate phosphate uptake through a mechanisms that involve do novo protein and/or RNA... -
Transepithelial Transport of Organic Cation and Its Inhibition by Sulfhydryl and Carboxyl Reagents in Opossum Kidney Cell Monolayer
Woo, Jae-Suk, Oh, Se-Ok, Jung, Jin-Sup, Kim, Yong-Keun, Lee, Sang-Ho 대한생리학회 대한생리학회지 10 Pages
대한생리학회 대한생리학회지 1996, 제 30권 제 1호 6 53-62 (10 pages)
transport, suggesting that the TEA self-exchange mechanism was involved at the apical membrane. Sulfhydryl reagents such as {\rho}-chloromercuribenzoic acid (PCMB) and ρ-chloro-mercuribenzene sulfonate (PCMBS) and carboxyl reagents such as N,N -dicyclohexylcarbodiimidem (DCCD) and N-ethoxy-carbonyl-2-ethoxy-1,2-dihydro-quinoline(EEDQ) inhibited the TEA transport at both the basolateral and apical membranes of the OK cell monolayer. These results suggest that OK cell monolayers possess a... -
Effects of α1-Adrenergic Receptor Stimulation on Intracellular Na+ Activity and Twitch Force in Guinea-Pig Ventricular Muscles
Chae, Soo-Wan, Gong, Q.Y., Wang, D.Y., Lee, Chin-O. 대한생리학회 대한생리학회지 14 Pages
대한생리학회 대한생리학회지 1995, 제 29권 제 2호 2 203-216 (14 pages)
antagonist of the α1-adrenergic receptor, but not by atenolol, an antagonist of the β-adrenergic receptor. This indicates that the changes in membrane potential, intracellular Na+ activity, and twitch force are mediated by stimulation of the α1-adrenergic receptor, but not by stimulation of β-adrenergic receptor. The decrease in intracellular Na+ activity was not observed in quiescent muscles, depending on the rate of the action pontentials in beating muscles. The intracellular Na+ activity... -
Effects of High Glucose on Na,K-ATPase and Na/glucose Cotransporter Activity in Primary Rabbit Kidney Proximal Tubule Cells
Han, Ho-Jae 대한생리학회 대한생리학회지 12 Pages
대한생리학회 대한생리학회지 1995, 제 29권 제 1호 7 69-80 (12 pages)
the progression to renal failure, an understanding of their underlying causes is potentially important for the development of therapy. A primary rabbit kidney proximal tubule cell culture system was utilized to evaluate the possibility that the renal proximal tubular hypertrophy and hyperfunction observed in vivo in diabetes mellitus, can be attributed to effects of elevated glucose levels on membrane transport systems. Primary cultures of rabbit proximal tubules, which achieved confluence at 10... -
Properties of Single K+ Channels of Skeletal Muscle Incorporated into Planar Lipid Bilayer
Park, Jin-Bong, Kim, Hee-Jeong, Cho, Myung-Haing, Lee, Hang, Park, Hong-Ki, Lee, Mun-Han, Ryu, Pan-Dong 대한생리학회 대한생리학회지 16 Pages
대한생리학회 대한생리학회지 1995, 제 29권 제 1호 2 13-28 (16 pages)
the intracellular [Ca2+] and 1/[Ca2+], respectively. The second K+ channel showed a conductance substate at 30 ~ 60% of the open state. Its current-voltage relation was linear in the range of -80 ~ +80 mV. The slope conductance of the substate and open-state were 40 and 144 pS in 0.2 M KCl, respectively. The channel was highly selective for K+ over Cl. The open-state probability was weakly voltage-dependent (e-fold change per 35 mV. The lifetime distributions of open- and closed-states were... -
Effects of In Vitro Exposure to Silica on Bioactive Mediator Release by Alveolar Macrophages
Lee, Ji-Hee 대한생리학회 대한생리학회지 12 Pages
대한생리학회 대한생리학회지 1995, 제 29권 제 1호 1 1-12 (12 pages)
in the pathogenesis of silicosis since the macrophages may release a wide variety of toxic and inflammatory mediators as well as mitogenic growth factors. In the present study, the effects of in vitro exposure to silica on release of various mediator such as reactive oxygen species, platelet activating factor(PAF), and interleukin-1 (IL-1) by alveolar macrophages were examined. First, hydrogen peroxide release from alveolar macrophages was monitored by measuring the change in fluorescence of... -
Rapid Measurement of NH3 and Weak Acid Permeation Through Liposomes and Renal Proximal Tubule Membranes
Bae, Hae-Rahn, Suh, Duck-Joon, Lee, Sang-Ho 대한생리학회 대한생리학회지 12 Pages
대한생리학회 대한생리학회지 1994, 제 28권 제 2호 11 203-214 (12 pages)
Using the methods of stopped-flow and epifluorescence microscopy with entrapped fluorophore, membrane permeability of NH3 and weak acids in liposomes, renal brush border (BBMV) and basolateral membrane vesicles (BLMV), and primary culture cells from renal proximal tubule was measured. Permeability coefficient (cm/sec) of NH3 was (2.9 X 10-2 in phosphatidylcholine liposome 25℃), 5.9 X 10-2 in renal proximal tubule cell (37℃), 4.0 X 10-2 and 2.4 X 10-2 in BBMV and BLMV (25℃), respectively....
