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2041.

Effects of Interleukin-1β and Tumor Necrosis Factor-α on the Release of Collagenase and Gelatinase from Osteoblasts

Jong-GabEun, Dong-HeonBaek, Se-WonKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2002, Vol.6 No.5 6 269-274 (6 pages)

Jong-GabEun, Dong-HeonBaek, Se-WonKim 저
...
- 3,000원
cell culture, and there was no additional increase according to the culture period. Osteoblastic cells released the gelatinase and molecular weight of this enzyme was measured about 70 KDa as assessed by zymogram. IL-1β and TNF-α showed increase of the gelatinase activity produced by ROS17/2.8 and HOS cells. Taken together, this study suggested that IL-1β and TNF-α can modulate bone metabolism, at least in part, by increased release of collagenase and gelatinase from osteoblasts.
2042.

Interactions between Estradiol-17β-BSA and Calcitropic Hormones in Ca2+ Uptake in Renal Proximal Tubule Cells

HoJaeHan, YeunHeeLee, EunJuSeo 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2002, Vol.6 No.5 5 261-268 (8 pages)

HoJaeHan, YeunHeeLee, EunJuSeo 저
...
- 3,000원
The aim of the present study was to investigate the interaction of estradiol-17β-bovine serum albumin (E2-BSA) and calcitropic hormones, such as parathyroid hormone, calcitonin, and vitamin D, in regulation of Ca2⁢ uptake in primary cultured renal proximal tubule cells. Statistically significant increase in Ca2⁢ uptake was found from 2 hours after E2-BSA (10⁣9 M) treatment, while estradiol-17β (10⁣9 M) did not affect. Treatment of the cells with E2-BSA (10⁣9 M)...
2043.

Modulation of Inwardly Rectifying K+ Channel by Intracellular and Extracellular pH in Bovine Aortic Endothelial Cells

Kyu-SangPark, InDeokKong, JoongWooLee, HyewhonRhim, YoungChulKim, InsukSo, KiWhanKim, 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2002, Vol.6 No.5 4 255-260 (6 pages)

Kyu-SangPark, InDeokKong, JoongWooLee, HyewhonRhim, YoungChulKim, InsukSo, KiWhanKim, 저
...
- 3,000원
in BAECs using reverse transcriptase-polymerase chain reaction (RT-PCR) analysis. Intracellular alkalinization, elicited by the extracellular substitution of NaCl with NH4Cl (30 mM), significantly augmented the amplitude of IRK current. On the contrary, the amplitude of IRK current was attenuated by the Na-acetate (30 mM)-induced intracellular acidification. The changes in extracellular pH also closely modulated the amplitude of IRK current, which was decreased to 40.2⁑1.3% of control upon...
2044.

Identification of ATP-sensitive K+ Conductances in Male Rat Major Pelvic Ganglion Neurons

Kyu-SangPark, Seung-KyuCha, Keon-IlLee, JaeYeoulJun, Seong-WooJeong, InDeokKong, JoongWooLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2002, Vol.6 No.5 3 247-254 (8 pages)

Kyu-SangPark, Seung-KyuCha, Keon-IlLee, JaeYeoulJun, Seong-WooJeong, InDeokKong, JoongWooLee 저
...
- 3,000원
to the electrophysiological properties; membrane capacitance (Cm), expression of T-type Ca2⁢ channels, and the firing patterns during depolarization. In the present study, function and molecular expression of ATP-sensitive K⁢ (KATP) channels was investigated in MPG neurons of male rats. Only in parasympathetic MPG neurons showing phasic firing patterns, hyperpolarizing changes were elicited by the application of diazoxide, an activator of KATP channels. Glibenclamide (10μM), a KATP...
2045.

The Preventive Effects of Bcl-2 and Bcl-xL on Lovastatin-induced Apoptosis of C6 Glial Cells

JaeWonChoi, JongMinLee, YoungJunOh 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2002, Vol.6 No.5 1 235-240 (6 pages)

JaeWonChoi, JongMinLee, YoungJunOh 저
...
- 3,000원
It has been reported that lovastatin induced cell death and suppressed proliferation in various cell lines. In this study, we examined whether the cytotoxic effects of lovastatin could be prevented by Bcl-2 or Bcl-xL in C6 glial cells. Overexpression of human Bcl-2 or Bcl-xL prevented lovastatin (25μM)- induced changes such as DNA fragmentation, chromatin condensation, disruption of cell membrane, and cleavage of poly (ADP-ribose) polymerase. Lovastatin-induced inhibition of cell proliferation...
2046.

Role of Calmodulin in the Generation of Reactive Oxygen Species and Apoptosis Induced by Tamoxifen in HepG2 Human Hepatoma Cells

YongSooLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2002, Vol.6 No.4 3 187-192 (6 pages)

YongSooLee 저
...
- 3,000원
Tamoxifen, an antiestrogen, has previously been shown to induce apoptosis in HepG2 human hepatoblastoma cells through activation of the pathways independent of estrogen receptors, i.e., intracellular Ca2⁢ increase and generation of reactive oxygen species (ROS). However, the mechanism of tamoxifen to link increased intracellular Ca2⁢ to ROS generation is currently unknown. Thus, in this study we investigated the possible involvement of calmodulin, a Ca2⁢ activated protein, and...
2047.

Differential Changes of ATP-sensitive Potassium Channel Current after Hypoxia-reperfusion Treatment in Mouse Neuroblastoma 2a (N2a) Cell

Ji-HoPark 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 4 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2002, Vol.6 No.4 2 183-186 (4 pages)

Ji-HoPark 저
...
- 1,500원
Ischemic damage is one of the most serious problems. The openers of KATP channel have been suggested to have an effect to limit the ischemic damage. However, it is not yet clear how KATP channels of a cell correspond to hypoxic damage. To address the question, N2a cells were exposed to two different hypoxic conditions as follows: 6 hours hypoxia followed by 3 hours reperfusion and 12 hours hypoxia followed by 3 hours reperfusion. As the results, 6 hours hypoxic treatment increased...
2048.

A Role of Mitogen Activated Protein Kinases and Inflammatory Responses in Gender Differences in Kidney Ischemia Injury

KwonMooParkHoJaeHan 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2002, Vol.6 No.3 5 155-160 (6 pages)

KwonMooParkHoJaeHan 저
...
- 3,000원
It is not known whether gender differences play a role in susceptibility to ischemic acute renal failure. Thus, we examined if there were any differences in susceptibility between male and female mice to kidney ischemic injury, and if so, whether it is due to differences in mitogen activated protein kinases (MAPKs) or inflammatory responses to ischemia. Female mice were protected against kidney ischemia when compared with males. Thirty minutes of bilateral ischemia resulted in marked functional...
2049.

Upregulation of Renal Renin-Angiotensin System in Rats with Adriamycin-Induced Nephrosis

SooWanKim, JongUnLee, Sang-WoongHan, JunHoRyu, YoonWhaOh, NamHoKim, KiChulChoi, Ho-JungKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 4 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2002, Vol.6 No.2 10 127-130 (4 pages)

SooWanKim, JongUnLee, Sang-WoongHan, JunHoRyu, YoonWhaOh, NamHoKim, KiChulChoi, Ho-JungKim 저
...
- 1,500원
The present study was aimed to investigate whether the adriamycin-induced nephrosis is associated with an altered regulation of local renin-angiotensin system (RAS) in the kidney. Rats were subjected to a single injection of adriamycin (2 mg/kg body weight, IV) and kept for 6 weeks to allow the development of nephrosis. They were then divided into two groups, and supplied with and without cilazapril, an angiotensin converting enzyme (ACE) inhibitor, in drinking water (100 mg/l) for additional 6...
2050.

Changes in the Expressional Levels of Sarcoplasmic Reticulum Ca2+-regulatory Proteins in the Postnatal Developing Rat Heart

EunHeeLee, SooSungPark, JaeSungLee, YoungJuSeo, Young-HoonKim, HaeWonKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2002, Vol.6 No.2 6 101-108 (8 pages)

EunHeeLee, SooSungPark, JaeSungLee, YoungJuSeo, Young-HoonKim, HaeWonKim 저
...
- 3,000원
In the present study, the postnatal developmental changes in the expressional levels of cardiac sarcoplasmic reticulum (SR) Ca2⁢ regulatory proteins, i.e. Ca2⁢-ATPase, phospholamban, and Ca2⁢ release channel, were investigated. Both SR Ca2⁢-ATPase and phospholamban mRNA levels were about 35% of adult levels at birth and gradually increased to adult levels. Protein levels of both SR Ca2⁢-ATPase and phospholamban, which were measured by quantitative immunoblotting,...

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