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201.

The activation of α2-adrenergic receptor in the spinal cord lowers sepsis-induced mortality

Sung-SuKim, Soo-HyunPark, Jae-RyungLee, Jun-SubJung, Hong-WonSuh 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 13 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2017, Vol.21 No.5 5 495-507 (13 pages)

Sung-SuKim, Soo-HyunPark, Jae-RyungLee, Jun-SubJung, Hong-WonSuh 저
...
- 4,200원
The effect of clonidine administered intrathecally (i.t.) on the mortality and the blood glucose level induced by sepsis was examined in mice. To produce sepsis, the mixture of D-galactosamine (GaLN; 0.6 g/10 ml)/lipopolysaccharide (LPS; 27 µg/27 µl) was treated intraperitoneally (i.p.). The i.t. pretreatment with clonidine (5 µg/5 µl) increased the blood glucose level and attenuated mortality induced by sepsis in a dose-dependent manner. The i.t. post-treatment with...
202.

Inhibition of anterior cingulate cortex excitatory neuronal activity induces conditioned place preference in a mouse model of chronic inflammatory pain

SukjaeJoshuaKang, SiyongKim, JaehyunLee, ChuljungKwak, KyungminLee, MinZhuo, Bong-KiunKaang 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2017, Vol.21 No.5 4 487-493 (7 pages)

SukjaeJoshuaKang, SiyongKim, JaehyunLee, ChuljungKwak, KyungminLee, MinZhuo, Bong-KiunKaang 저
...
- 3,000원
The anterior cingulate cortex (ACC) is known for its role in perception of nociceptive signals and the associated emotional responses. Recent optogenetic studies, involving modulation of neuronal activity in the ACC, show that the ACC can modulate mechanical hyperalgesia. In the present study, we used optogenetic techniques to selectively modulate excitatory pyramidal neurons and inhibitory interneurons in the ACC in a model of chronic inflammatory pain to assess their motivational effect in the...
203.

Electrophysiological characteristics of R47W and A298T mutations in CLC-1 of myotonia congenita patients and evaluation of clinical features

HyungJinChin, ChanHyeongKim, KotdajiHa, JinHongShin, Dae-SeongKim, InsukSo 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2017, Vol.21 No.4 10 439-447 (9 pages)

HyungJinChin, ChanHyeongKim, KotdajiHa, JinHongShin, Dae-SeongKim, InsukSo 저
...
- 3,000원
Myotonia congenita (MC) is a genetic disease that displays impaired relaxation of skeletal muscle and muscle hypertrophy. This disease is mainly caused by mutations of CLCN1 that encodes human skeletal muscle chloride channel (CLC-1). CLC-1 is a voltage gated chloride channel that activates upon depolarizing potentials and play a major role in stabilization of resting membrane potentials in skeletal muscle. In this study, we report 4 unrelated Korean patients diagnosed with myotonia congenita...
204.

Escitalopram, a selective serotonin reuptake inhibitor, inhibits voltage-dependent K+ channels in coronary arterial smooth muscle cells

HanSolKim, HongliangLi, HyeWonKim, SungEunShin, MiSeonSeo, JinRyeolAn, Kwon-SooHa, Eun-TaekHan, Seok-HoHong, Il-WhanChoi, GraceChoi, Dae-su 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2017, Vol.21 No.4 7 415-421 (7 pages)

HanSolKim, HongliangLi, HyeWonKim, SungEunShin, MiSeonSeo, JinRyeolAn, Kwon-SooHa, Eun-TaekHan, Seok-HoHong, Il-WhanChoi, GraceChoi, Dae-su 저
...
- 3,000원
We investigated the inhibitory effect of escitalopram, a selective serotonin reuptake inhibitor (SSRI), on voltage-dependent K+ (Kv) channels in freshly separated from rabbit coronary arterial smooth muscle cells. The application of escitalopram rapidly inhibited vascular Kv channels. Kv currents were progressively inhibited by an increase in the concentrations of escitalopram, suggesting that escitalopram inhibited vascular Kv currents in a concentration-dependent manner. The IC50 value and...
205.

Elucidation of the profound antagonism of contractile action of phenylephrine in rat aorta effected by an atypical sympathomimetic decongestant

EldinaRizvi, GoranJankovi, MiroslavM.Savi 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 11 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2017, Vol.21 No.4 4 385-395 (11 pages)

EldinaRizvi, GoranJankovi, MiroslavM.Savi 저
...
- 4,000원
Vasoconstrictive properties of sympathomimetic drugs are the basis of their widespread use as decongestants and possible source of adverse responses. Insufficiently substantiated practice of combining decongestants in some marketed preparations, such are those containing phenylephrine and lerimazoline, may affect the overall contractile activity, and thus their therapeutic utility. This study aimed to examine the interaction between lerimazoline and phenylephrine in isolated rat aortic rings,...
206.

Peroxisome proliferator-activated receptor γ is essential for secretion of ANP induced by prostaglandin D2 in the beating rat atrium

YingZhang, XiangLi, Li-PingLiu, LanHong, XiaLiu, BoZhang, Cheng-ZheWu, XunCui 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2017, Vol.21 No.3 3 293-300 (8 pages)

YingZhang, XiangLi, Li-PingLiu, LanHong, XiaLiu, BoZhang, Cheng-ZheWu, XunCui 저
...
- 3,000원
Prostaglandin D2 (PGD2) may act against myocardial ischemia–reperfusion (I/R) injury and play an anti-inflammatory role in the heart. Although the effect of PGD2 in regulation of ANP secretion of the atrium was reported, the mechanisms involved are not clearly identified. The aim of the present study was to investigate whether PGD2 can regulate ANP secretion in the isolated perfused beating rat atrium, and its underlying mechanisms. PGD2 (0.1 to 10 μM) significantly increased atrial ANP...
207.

Nortriptyline, a tricyclic antidepressant, inhibits voltage-dependent K+ channels in coronary arterial smooth muscle cells

SungEunShin, HongliangLi, HanSolKim, HyeWonKim, MiSeonSeo, Kwon-SooHa, Eun-TaekHan, Seok-HoHong, AmyL.Firth, Il-WhanChoi6, YoungMinBae, Won 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2017, Vol.21 No.2 10 225-232 (8 pages)

SungEunShin, HongliangLi, HanSolKim, HyeWonKim, MiSeonSeo, Kwon-SooHa, Eun-TaekHan, Seok-HoHong, AmyL.Firth, Il-WhanChoi6, YoungMinBae, Won 저
...
- 3,000원
We demonstrated the effect of nortriptyline, a tricyclic antidepressant drug and serotonin reuptake inhibitor, on voltage-dependent K+ (Kv) channels in freshly isolated rabbit coronary arterial smooth muscle cells using a whole-cell patch clamp technique. Nortriptyline inhibited Kv currents in a concentration-dependent manner, with an apparent IC50 value of 2.86±0.52 µM and a Hill coefficient of 0.77±0.1. Although application of nortriptyline did not change the activation curve,...
208.

Quercetin induces apoptosis and cell cycle arrest in triple-negative breast cancer cells through modulation of Foxo3a activity

LichThiNguyen, Yeon-HeeLee, AshishRanjanSharma, Jong-BongPark, SupriyaJagga, GarimaSharma, Sang-SooLee, Ju-SukNam 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2017, Vol.21 No.2 8 205-213 (9 pages)

LichThiNguyen, Yeon-HeeLee, AshishRanjanSharma, Jong-BongPark, SupriyaJagga, GarimaSharma, Sang-SooLee, Ju-SukNam 저
...
- 3,000원
Quercetin, a plant-derived flavonoid found in fruits, vegetables and tea, has been known to possess bioactive properties such as anti-oxidant, anti-inflammatory and anti-cancer. In this study, anti-cancer effect of quercetin and its underlying mechanisms in triple-negative breast cancer cells was investigated. MTT assay showed that quercetin reduced breast cancer cell viability in a time and dose dependent manner. For this, quercetin not only increased cell apoptosis but also inhibited cell...
209.

Effect of oleanolic acid on the activity, secretion and gene expression of matrix metalloproteinase-3 in articular chondrocytes in vitro and the production of matrix metalloproteinase-3 in vivo

Dong-GeunKang, HyunJaeLee, KunTaeKim, Sun-ChulHwang, ChoongJaeLee, JinSungPark 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2017, Vol.21 No.2 7 197-204 (8 pages)

Dong-GeunKang, HyunJaeLee, KunTaeKim, Sun-ChulHwang, ChoongJaeLee, JinSungPark 저
...
- 3,000원
In the present study, we tried to examine whether oleanolic acid regulates the activity, secretion and gene expression of matrix metalloproteinase-3 (MMP-3) in primary cultured rabbit articular chondrocytes, as well as the production of MMP-3 in the knee joint of rat to evaluate the potential chondroprotective effect of oleanolic acid. Rabbit articular chondrocytes were cultured in a monolayer, and reverse transcription-polymerase chain reaction (RT-PCR) was used to measure interleukin-1β...
210.

Paracrine influence of human perivascular cells on the proliferation of adenocarcinoma alveolar epithelial cells

EunbiKim, SunghunNa, BorimAn, Se-RanYang, WooJinKim, Kwon-SooHa, Eun-TaekHan, WonSunPark, Chang-MinLee, JiYoonLee, Seung-JoonLee, Seok-HoHo 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2017, Vol.21 No.2 3 161-168 (8 pages)

EunbiKim, SunghunNa, BorimAn, Se-RanYang, WooJinKim, Kwon-SooHa, Eun-TaekHan, WonSunPark, Chang-MinLee, JiYoonLee, Seung-JoonLee, Seok-HoHo 저
...
- 3,000원
Understanding the crosstalk mechanisms between perivascular cells (PVCs) and cancer cells might be beneficial in preventing cancer development and metastasis. In this study, we investigated the paracrine influence of PVCs derived from human umbilical cords on the proliferation of lung adenocarcinoma epithelial cells (A549) and erythroleukemia cells (TF-1α and K562) in vitro using TranswellⓇ co-culture systems. PVCs promoted the proliferation of A549 cells without inducing morphological...

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