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211.

Effects of Kanagawa Hemolysin on Blood Pressure and Arterial Tone in Rats

YoungMoonKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2002, Vol.6 No.4 8 225-233 (9 pages)

YoungMoonKim 저
...
- 3,000원
of the same dose of KH induced a prominent depressor effect (iv KH-depressor effect). The icv KH-pressor effect was inhibited by acid-denaturation, while the iv KH-depressor effect was not. Simultaneous icv administration of the three agents (ouabain, diltiazem, or bumetanide: 10μg/kg each) significantly reduced the pressor effect. The icv KH-pressor effect was inhibited by treatment with iv phentolamine or chlorisondamine, but was not affected by iv candesartan. The iv KH-depressor effect was...
212.

Role of Calmodulin in the Generation of Reactive Oxygen Species and Apoptosis Induced by Tamoxifen in HepG2 Human Hepatoma Cells

YongSooLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2002, Vol.6 No.4 3 187-192 (6 pages)

YongSooLee 저
...
- 3,000원
apoptosis in a dose-dependent manner. In addition, these agents blocked the tamoxifen-induced ROS generation in a concentration-dependent fashion, which was completely suppressed by intracellular Ca2⁢ chelation. These results demonstrate for the first time that, despite of its well-known direct calmodulin-inhibitory activity, tamoxifen may generate ROS and induce apoptosis through indirect activation of calmodulin and Ca2⁢/calmodulin-dependent protein kinase II in HepG2 cells.
213.

Analysis of a Sphingosine 1-phosphate Receptor hS1P3 in Rat Hepatoma Cells

Dong-SoonIm 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 4 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2002, Vol.6 No.3 2 139-142 (4 pages)

Dong-SoonIm 저
...
- 1,500원
forskolin-induced activation of adenylyl cyclase activity by about 80% and activated MAP kinases in dose-dependent and pertussis-toxin (PTX) sensitive manners. In oocytes expressing hS1P3 receptor, S1P evoked Cl⁣ conductance. These data suggested that PTX-sensitive G proteins are involved in hS1P3-mediated signaling, especially the positive action of S1P in cell proliferation. The potential advantages of rat hepatoma cells for the research of sphingosine 1-phosphate receptor are discussed.
214.

Effect of Serotonin Uptake Inhibitors on Serotonin Metabolism in the Hypothalamus of Freely Moving Rats

YunSeobSong, SeNaYoon, DongSikJung, SangHeeYoo, HyongKyunRyu, HyungGunKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 11 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2000, Vol.4 No.6 1 427-437 (11 pages)

YunSeobSong, SeNaYoon, DongSikJung, SangHeeYoo, HyongKyunRyu, HyungGunKim 저
...
- 4,000원
Tricyclic antidepressant clomipramine or selective serotonin reuptake inhibitors (SSRIs) have been commonly used for the treatment of premature ejaculation. In the present study, we analyzed the concentrations of serotonin and 5-hydroxyindoleacetic acid (5-HIAA) in the medial preoptic area (MPOA) of the hypothalamus by awakening animal microdialysis following administration of clomipramine and various SSRIs. We then compared the serotonin metabolism and clinical effects of clomipramine and...
215.

Comparison of Neurotoxicity Induced by Some Glutathione Depletors in Mouse Cortical Cell Cultures

Gee-WoonLee, Kuy-SookLee, Sah-HoonPark, ChoonSangBae, Jong-KeunKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2000, Vol.4 No.3 2 177-183 (7 pages)

Gee-WoonLee, Kuy-SookLee, Sah-HoonPark, ChoonSangBae, Jong-KeunKim 저
...
- 3,000원
buthionine sulfoximine (BSO), diethyl maleate (DEM) and phorone, under the presence of trolox, cycloheximide (CHX), pyrrolidine dithiocarbamate (PDTC) or MK-801 in primary mouse cortical cell cultures. All three depletors induced neuronal death in dose and exposure time dependent manner, and decreased total cellular GSH contents. The patterns of the neuronal death and the GSH decrements were dependent on the individual agents. DEM (200 μM) induced rapid and irreversible decrement of the GSH. B...
216.

Selective Cytotoxicity of a Novel Platinum(II) Coordination Complex on Human Bladder Cancer Cell Lines and Normal Kidney Cells

Jee-ChangJung, Joo-HoChung, Sung-GooChang, Young-SooRho 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2000, Vol.4 No.2 11 159-167 (9 pages)

Jee-ChangJung, Joo-HoChung, Sung-GooChang, Young-SooRho 저
...
- 3,000원
We have synthesized a novel platinum(II) coordination complex containing cis-1,2-diaminocyclohexane (DACH) as a carrier ligand and 1,2-dichloroethane (DCE) as a leaving group. In addition, nitrate was added to improve the water-solubility. A new series of [Pt(cis-DACH)(DCE)]·2NO3(PC) was evaluated for its cytotoxic activity on T-24 and J-82 human bladder carcinoma cells and normal primary cultured kidney cells. PC has demonstrated high levels of cytotoxicity against T-24 and J-82 cells. The...
217.

Effect of Brain Angiotensin II Receptor Antagonists and Antisense Oligonucleotide on Drinking and Renal Renin in Rats

Hyeon-kyeongCho, Eun-kyoungYang, Hee-sukHan, Won-jungLee, M.IanPhillips 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2000, Vol.4 No.2 8 137-142 (6 pages)

Hyeon-kyeongCho, Eun-kyoungYang, Hee-sukHan, Won-jungLee, M.IanPhillips 저
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- 3,000원
The physiological roles of brain angiotensin II in mediating water deprivation-induced drinking and in regulating renal renin release were assessed in male Sprague-Dawley rats. Specific AT1 receptor antagonists, losartan and SK 1080, and antisense oligonucleotide (AS-ODN) directed to AT1 receptor mRNA were intracerebroventricularly (i.c.v.) administered in conscious unrestrained rats. When water was given 20 min after i.c.v. injection of AT1 receptor antagonists in 48-h water-deprived rats,...
218.

Effects of p-Chlorophenylalanine on the Synthesis of Pancreatic Amylase in Rats

HyeokYilKwon, WonSikEum, HyunWooJang, YunLyulLee, HyoungJinPark 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2000, Vol.4 No.2 7 129-135 (7 pages)

HyeokYilKwon, WonSikEum, HyunWooJang, YunLyulLee, HyoungJinPark 저
...
- 3,000원
Previously, we have reported that p-chlorophenylalanine (PCPA), a serotonin depletor, profoundly increased pancreatic fluid and bicarbonate secretion but remarkably inhibited pancreatic amylase secretion in anesthetized rats. The present study was performed to verify the detailed effects of PCPA on pancreatic amylase synthesis that is directly related to amylase exocrine secretion. PCPA significantly decreased pancreatic RNA and protein contents as well as the amylase activity. However,...
219.

Muscarinic Receptor Subtype Controlling the Carbachol-Induced Muscle Contraction in Guinea Pig Gastric Antrum

JongChulRhee, Dae-YongUhm, TongMookKang 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2000, Vol.4 No.2 4 105-111 (7 pages)

JongChulRhee, Dae-YongUhm, TongMookKang 저
...
- 3,000원
in a dose-dependent way, and each of the three muscarinic receptor antagonists, 4-diphenylacetoxy- N-methylpeperdine methiodide (4-DAMP), methoctramine and pirenzepine shifted the concentration- response curves to the right without significantly reducing the maximum force. The affinities of the muscarinic antagonists (pA2 values) obtained from Schild plot analysis were 10.15, 7.05 and 6.84 for 4-DAMP, methoctramine and pirenzepine, respectively. These results suggest that the M3-subtype mainly...
220.

Effect of Propofol, an Intravenous Anesthetic Agent, on KATP Channels of Pancreatic β-cells in Rats

EunJeePark, Dae-KyuSong, JaeKyuCheun, JungInBae, Won-KyungHo, YungEEarm 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2000, Vol.4 No.1 4 25-31 (7 pages)

EunJeePark, Dae-KyuSong, JaeKyuCheun, JungInBae, Won-KyungHo, YungEEarm 저
...
- 3,000원
in a dose-dependent manner. The half-maximal inhibition dose (ED50) was 48.6⁑8.4μM and the Hill coefficient was 0.73⁑0.11. Single channel conductance calculated from the slope of the relationship between single channel current and pipette potential (⁢20∼⁢100 mV) was not significantly altered by propofol (control: 60.0⁑2.7 pS, 0.1 mM propofol: 58.7⁑3.5 pS). However, mean closed time was surely increased. Above results indicate that propofol blocks the KATP...

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