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Gradual Reperfusion Lowers the Incidence of Reperfusion-Induced Ventricular Fibrillation in a Cat Model of Regional Ischemia
You-HoKim, HeungSikNa, HyunJungNam, Gyu-YoungHur, Seung-WhanLee, SungSookPark, SeungKilHong 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1999, Vol.3 No.1 6 47-52 (6 pages)
Blood flow restoration to ischemic zone of the heart is essential to salvage of ischemic tissue. However, there is a large body of evidence documenting that the reperfusion can induce reperfusion injury like reperfusion-induced malignant arrhythmias. In the present study, employing a cat model of regional cardiac ischemia, we examined if reperfusion rendered in a gradual fashion could lower the incidence of reperfusion-induced ventricular fibrillation (VF), which usually precipitated within a... -
Involvement of Adenosine in Cardioprotective Effect of Catecholamine Preconditioning in Ischemia-Reperfused Heart of Rat
Young-hoonKim, Chan-hyungKim, Gi-taeKim, In-kyuKim, Jong-wanPark, Myung-sukKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1998, Vol.2 No.6 12 753-761 (9 pages)
-agonist, isoproterenol(109∼107 M) markedly improved the post-ischemic mechanical function and reduced the lactate dehydrogenase release. Similar cardioprotective effect was observed with an -agonist, phenylephrine pretreatment, but much higher concentration(104 M) was needed to achieve the same degree of cardioprotection. The cardioprotective effects of isoproterenol and phenylephrine pretreatments were blocked by a 1-adrenergic receptor antagonist,... -
Dopaminergic Inhibition of Dorsal Horn Cell Activity in the Cat
KyungChulKim, HongKeeShin, KeeSoonKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 10 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1998, Vol.2 No.6 2 661-670 (10 pages)
in behavioral pain test, such as tail flick and hot plate test, but there appears to be a great variance in the reports on the antinociceptive effect of dopamine depending on the dosage and route of drug administration and type of animal preparation. In the present study, the effects of dopamine on the responses of wide dynamic range (WDR) cells to mechanical, thermal and graded electrical stimuli were investigated, and the dopamine-induced changes in WDR cell responses were compared between... -
Altered Cerebral Vasomotion with Decreased CGRP Level in Pial Arteries of Spontaneously Hypertensive Rats
KwangHoLee, JaeMoonChoi, KiWhanHong 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1998, Vol.2 No.5 5 573-580 (8 pages)
exerts a modulator role in the autoregulation of cerebral blood flow (CBF). The animals were divided into four groups: 1) Sprague-Dawley rats (SDR), 2) Wistar rats (WR), 3) SHR with high blood pressure (BP≥150 mmHg), and 4) SHR with normotensive BP (≤150 mmHg). The lower limit of CBF autoregulation in SHR shifted to a higher BP (82.8⁑9.3 mmHg, P＜0.05) than that in SDR (58.9⁑5.7 mmHg). In SHR, whether the BP levels were high or normotensive, the vasodilator responses to a stepwise... -
Nitric Oxide Impairs the Recovery from Hemorrhagic Hypotension in Conscious Rats
Yoon-yubParkYoung-ManLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1998, Vol.2 No.3 9 345-351 (7 pages)
femoral arterial catheter until the mean arterial pressure (MAP) was reduced by 50 mmHg. We studied the responses to hemorrhage under normal condition (Control) and after the pretreatment with 3 doses of L-NAME (1.6, 8, 40 mg/kg i.v. of NOX1.6, NOX8, and NOX40, respectively). Intravenous bolus injection of L-NAME produced a sustained increase in MAP and decrease in heart rate (HR). During hemorrhage, the MAP fell faster in the NOX8 and NOX40-treated groups than in Control group, but the control... -
Characteristics of A1 and A2 Adenosine Receptors upon the Acetylcholine Release in the Rat Hippocampus
DoKyungKim, YoungSooLee, BongKyuChoi 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1998, Vol.2 No.1 4 31-39 (9 pages)
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Adenosine 수용체 작동제 장기 투여의 신장효과 Renal Effects of Chronic Treatment of Adenosine Analogues
김택희, 김선희, 허종, 조경우, TackHeeKim, SuhnHeeKim, JongHuh, KyungWooCho 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 11 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1997, Vol.1 No.3 11 325-335 (11 pages)
in heart rate, blood pressure and general motor activity without change in rectal temperature. Systemic administration of CHA, 0.5, 1 and 2 mg/kg/day, for 3 days caused a dose-dependent increase in urine volume and decrease in urinary osmolarity and free water reabsorption. This phenomenon was reversible and repeatable. Administration of adenosine (40 mg/kg/day) produced no apparent effect on the renal function, whereas PIA (2 mg/kg/day) produced an similar effect to CHA on the renal function.... -
Effect of Cisplatin on Sodium-Dependent Hexose Transport in LLC-PK1 Renal Epithelial Cells
SukKyuLee, JeeYeunKim, TaiHyunYu, KyoungRyongKim, KwangHyukKim, YangSaengPark 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1997, Vol.1 No.1 5 35-43 (9 pages)
Cis-dichlorodiammine platinum II (Cisplatin), an effective chemotherapeutic agent, induces acute renal failure by unknown mechanisms. To investigate direct toxic effects of cisplatin on the renal proximal tubular transport system, LLC-PK1 cell line was selected as a cell model and the sugar transport activity was evaluated during a course of cisplatin treatment. Cells grown to confluence were treated with cisplatin for 60 min, washed, and then incubated for up to 5 days. At appropriate... -
한 중소도시의 청소년 약물사용 실태조사
이후경, 김선재, 윤성철, 봉수연, 안현주, 박선영 대한신경정신의학회 신경정신의학 14 Pages
대한신경정신의학회 신경정신의학 2001, 제 40권 제 1호 3 23-36 (14 pages)
연구목적： 약물사용의 가능성이 가장 높은 시기는 십대 후반에서 이십대 초반의 청소년기로 알려져 있다. 또한 청소 년기의 약물사용은 빠른 의존의 가능성, 심각한 약물남용으로 진행할 가능성, 약물로 인한 공격성의 증가 등 으로 심각한 사회문제가 될 여지가 많다. 그러므로 저자들은 중소도시에서 청소년 약물사용의 예방 및 치료 를 위한 정책을 마련하는데 기초가 될 수 있는 청소년 약물사용 실태를 조사하는 것을 목적으로 ㅎ시 청소년 상담실의 기금을 받아 본 연구를 시행하였다. 저자들이 세운 연구가설은 다음과 같다....
